Effect of inhibition of synthesis of inducible nitric oxide synthase-derived nitric oxide by aminoguanidine on the in vitro maturation of oocyte–cumulus complexes of cattle

2009 ◽  
Vol 111 (2-4) ◽  
pp. 189-201 ◽  
Author(s):  
S.G.C. Matta ◽  
M.C. Caldas-Bussiere ◽  
K.S. Viana ◽  
M.R. Faes ◽  
C.S. Paes de Carvalho ◽  
...  
1996 ◽  
Vol 108 (supplement) ◽  
pp. 115-120
Author(s):  
Yoshihisa KITAMURA ◽  
Hideaki TAKAHASHI ◽  
Yasuji MATSUOKA ◽  
Yasuyuki NOMURA ◽  
Takashi TANIGUCHI

FEBS Letters ◽  
1999 ◽  
Vol 462 (3) ◽  
pp. 241-245 ◽  
Author(s):  
Gianfranco Mamone ◽  
Nicola Sannolo ◽  
Antonio Malorni ◽  
Pasquale Ferranti

2002 ◽  
Vol 70 (9) ◽  
pp. 4826-4832 ◽  
Author(s):  
Yao-Hui Sun ◽  
Andreas B. den Hartigh ◽  
Renato de Lima Santos ◽  
L. Garry Adams ◽  
Renée M. Tsolis

ABSTRACT The Brucella abortus virB locus is required for establishing chronic infection in the mouse. Using in vitro and in vivo models, we investigated whether virB is involved in evasion of the bactericidal activity of NADPH oxidase and the inducible nitric oxide synthase (iNOS) in macrophages. Elimination of NADPH oxidase or iNOS activity in macrophages in vitro increased recovery of wild-type B. abortus but not recovery of a virB mutant. In mice lacking either NADPH oxidase or iNOS, however, B. abortus infected and persisted to the same extent as it did in congenic C57BL/6 mice up until 60 days postinfection, suggesting that these host defense mechanisms are not critical for limiting bacterial growth in the mouse. A virB mutant did not exhibit increased survival in either of the knockout mouse strains, indicating that this locus does not contribute to evasion of nitrosative or oxidative killing mechanisms in vivo.


1994 ◽  
Vol 109 (1-2) ◽  
pp. 107
Author(s):  
U. Malo-Ranta ◽  
J. Luoma ◽  
M. Laukkanen ◽  
T. Nikkari ◽  
S. Yla¨-Herttuala

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