Transient receptor potential vanilloid 4 (TRPV4) expression on the nerve fibers of human dental pulp is upregulated under inflammatory condition

2018 ◽  
Vol 89 ◽  
pp. 94-98 ◽  
Author(s):  
Marina M. Bakri ◽  
Farhana Yahya ◽  
Khalil Munawar Makhdum Munawar ◽  
Junichi Kitagawa ◽  
Mohammad Zakir Hossain
Keyword(s):  
Dental Pulp ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Nerve Fibers ◽  
Transient Receptor Potential Vanilloid ◽  
Inflammatory Condition ◽  
Human Dental Pulp ◽  
Transient Receptor

scholarly journals Human Dental Pulp Fibroblasts Express the “Cold-sensing” Transient Receptor Potential Channels TRPA1 and TRPM8

2011 ◽  
Vol 37 (4) ◽  
pp. 473-478 ◽  
Author(s):  
Ikhlas A. El Karim ◽  
Gerard J. Linden ◽  
Timothy M. Curtis ◽  
Imad About ◽  
Mary K. McGahon ◽  
...  
Keyword(s):  
Dental Pulp ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Channels ◽  
Human Dental Pulp ◽  
Potential Channels ◽  
Transient Receptor ◽  
Cold Sensing

scholarly journals Nicotine InhibitsClostridium difficileToxin A-Induced Colitis but Not Ileitis in Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Steven R. Vigna
Keyword(s):  
Nicotinic Receptor ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Vanilloid ◽  
Inflammatory Condition ◽  
Toxin A ◽  
Pharmacological Agents ◽  
Nicotinic Cholinergic Receptors ◽  
Transient Receptor ◽  
Nicotinic Receptor Antagonist

Nicotine is protective in ulcerative colitis but not Crohn’s disease of the small intestine, but little is known about the effects of nicotine onClostridium difficiletoxin A-induced enteritis. Isolated ileal or colonic segments in anesthetized rats were pretreated with nicotine bitartrate or other pharmacological agents before intraluminal injection of toxin A. After 3 hours, the treated segments were removed and inflammation was assessed. Nicotine biphasically inhibited toxin A colitis but not ileitis. Pretreatment with the nicotinic receptor antagonist, hexamethonium, blocked the effects of nicotine. Pretreating the colonic segments with hexamethonium before toxin A administration resulted in more inflammation than seen with toxin A alone, suggesting that a tonic nicotinic anti-inflammatory condition exists in the colon. Nicotine also inhibited toxin A-induced increased colonic concentrations of the TRPV1 (transient receptor potential vanilloid subtype 1) agonist, leukotriene B4(LTB4), and release of the proinflammatory neuropeptide, substance P. Pretreatment with nicotine did not protect against direct TRPV1-mediated colitis caused by intraluminal capsaicin. Nicotinic cholinergic receptors tonically protect the colon against inflammation and nicotine inhibits toxin A colitis but not toxin A ileitis in rats in part by inhibition of toxin A-induced activation of TRPV1 by endogenous TRPV1 agonists such as LTB4.

Expression of Transient Receptor Potential Ankyrin 1 in Human Dental Pulp

2012 ◽  
Vol 38 (8) ◽  
pp. 1087-1092 ◽  
Author(s):  
Yun Sook Kim ◽  
Hoon Kap Jung ◽  
Tae Kyung Kwon ◽  
Chin Soo Kim ◽  
Jin Hyun Cho ◽  
...  
Keyword(s):  
Dental Pulp ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Human Dental Pulp ◽  
Transient Receptor
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