Analgesic Efficacy of Perioperative Celecoxib in Ambulatory Arthroscopic Knee Surgery: A Double-Blind, Placebo-Controlled Study

Purpose. In a randomized, double-blind trial, the efficacy of nonopioid analgesics on postoperative piritramide consumption was compared for pain relief during the first 24 h in patients recovering from arthroscopic knee surgery. Methods. 120 patients were treated with normal saline and/or one of the nonopioid analgesics (parecoxib, metamizole, paracetamol) in addition to piritramide using the PCA pump. Beginning in the postanesthesia care unit (PACU), patients were asked to quantify their pain experience at rest while piritramide consumption was recorded. Results. Piritramide consumption upon arrival in the PACU was high in all groups. However, cumulative consumption in the parecoxib group was significantly lower than that in the placebo group at 6 and 12 h after surgery. At discharge from the PACU, VAS scores dropped in all groups and were significantly lower in the parecoxib group. In the PACU, satisfaction of the patients was moderate and improved with time after surgery. Conclusions. There was statistically significant opioid-saving effect by administering parecoxib with better VAS scores and satisfaction level compared to placebo. The high pain score in the PACU in all groups immediately after recovering from remifentanil-based anesthesia would be prevented if local anesthetics were administered intra-articularly as part of a multimodal analgesic approach.

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Clinical analgesic efficacy and side effects of dexmedetomidine in the early postoperative period after arthroscopic knee surgery

Journal of Clinical Anesthesia ◽

10.1016/j.jclinane.2007.06.013 ◽

2007 ◽

Vol 19 (8) ◽

pp. 576-582 ◽

Cited By ~ 29

Author(s):

Maria E. Gómez-Vázquez ◽

Eduardo Hernández-Salazar ◽

Abel Hernández-Jiménez ◽

Arturo Pérez-Sánchez ◽

Vilma A. Zepeda-López ◽

...

Keyword(s):

Side Effects ◽

Postoperative Period ◽

Analgesic Efficacy ◽

Early Postoperative Period ◽

Knee Surgery ◽

Arthroscopic Knee Surgery ◽

Arthroscopic Knee

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The Effect of Tourniquet Release Time on the Analgesic Efficacy of Intraarticular Morphine After Arthroscopic Knee Surgery

Survey of Anesthesiology ◽

10.1097/00132586-199804000-00051 ◽

1998 ◽

Vol 42 (2) ◽

pp. 108

Author(s):

ANNE WHITFORD ◽

M. HEALY ◽

GIRISH P. JOSHI ◽

S. M. MCCARROLL ◽

TIMOTHY M. O??BRIEN ◽

...

Keyword(s):

Analgesic Efficacy ◽

Knee Surgery ◽

Release Time ◽

Arthroscopic Knee Surgery ◽

Tourniquet Release ◽

Arthroscopic Knee

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Analgesic Effect of Dexamethasone after Arthroscopic Knee Surgery: A Randomized Controlled Trial

Pain Research and Management ◽

10.1155/2016/4216469 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6

Author(s):

Jairo Moyano ◽

Maria García ◽

Maria Caicedo

Keyword(s):

Postoperative Pain ◽

Pain Intensity ◽

Knee Surgery ◽

Controlled Study ◽

Opioid Use ◽

Arthroscopic Knee Surgery ◽

Randomized Controlled ◽

Significant Difference ◽

Intraoperative Period ◽

Arthroscopic Knee

Background.Dexamethasone is sometimes used as a coanalgesic because of its anti-inflammatory properties.Objective. To evaluate opioid use, postoperative pain intensity, and side effects after a single dose of dexamethasone in patients undergoing arthroscopic knee surgery.Methods. In this randomized controlled study patients were randomized to receive either 10 mg of intravenous dexamethasone (DM group) or 0.9% normal saline (NS group) during the intraoperative period. Primary outcomes were pain intensity and total morphine and codeine use after surgery.Results. Seventy-eight patients were included in the study. The DM group showed statistically significant higher pain intensity at the fourth postoperative hour (DM: 3.96/10, standard deviation [SD] 0.54; NS: 2.46/10, SD 0.45;p=0.036). No statistically significant difference in total opioid use (morphine plus codeine) was identified with 15.9 (SD 1.97) codeine tablets used in DM group and 20 (SD 2.14) in NS group (p=0.25).Discussion. Pain intensity tended to decrease in both groups suggesting morphine as the main source of analgesia.Conclusions. Intravenous dexamethasone during the intraoperative period has no clinical impact on postoperative pain intensity during the first 48 h after arthroscopic knee surgery. This trial is registered withR000020892.

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