Upstream regulation of matrix metalloproteinase by EMMPRIN; extracellular matrix metalloproteinase inducer in advanced atherosclerotic plaque

2005 ◽  
Vol 180 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Young Won Yoon ◽  
Hyuck Moon Kwon ◽  
Ki-Chul Hwang ◽  
Eui-Young Choi ◽  
Bum-kee Hong ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinase ◽  
Atherosclerotic Plaque ◽  
Extracellular Matrix Metalloproteinase Inducer

scholarly journals Angiotensin II induces extracellular matrix metalloproteinase inducer expression via an AT1R dependent pathway in aortic atherosclerotic plaque in apolipoprotein E knockout mice

2011 ◽  
Vol 13 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Li-xia Yang ◽  
Zhi-hua Yang ◽  
Rui-wei Guo ◽  
Jin-shan Ye ◽  
Hong Liu
Keyword(s):  
Extracellular Matrix ◽  
Angiotensin Ii ◽  
Matrix Metalloproteinase ◽  
Protein Expression ◽  
Atherosclerotic Plaque ◽  
Knockout Mice ◽  
Ang Ii ◽  
Extracellular Matrix Metalloproteinase Inducer ◽  
Apolipoprotein E Knockout Mice ◽  
Apoe Knockout Mice

The pathogenesis of acute coronary syndrome is rupture of vulnerable plaque. Extracellular matrix metalloproteinase inducer (EMMPRIN) is reported to have a important role in the destabilization of atheroma. Objectives: this investigation examined the effect of angiotensin II (Ang II) on EMMPRIN expression in atherosclerotic plaques in ApoE knockout mice. Methods: ApoE knockout mice were fed a high fat diet to establish an atherosclerosis model then intervention was made with Ang II and valsartan. EMMPRIN gene and its protein expression were measured by real-time PCR immunohistochemistry, and Western blot. Results: EMMPRIN gene and protein expression intervened with Ang II were significantly increased; valsartan could inhibit the effect of Ang II. Conclusion: Ang II up-regulated EMMPRIN expression in atherosclerotic plaque via AT1R, and valsartan could inhibit the effect of Ang II.

Expression of Extracellular Matrix Metalloproteinase Inducer in Nasal Polyps

2010 ◽  
Vol 24 (6) ◽  
pp. e127-e131 ◽  
Author(s):  
Jang-Hyeog Lee ◽  
Seung Won Chung ◽  
Il-Ho Park ◽  
Sang Hag Lee ◽  
Seung Hoon Lee ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinase ◽  
Nasal Polyps ◽  
Extracellular Matrix Metalloproteinase Inducer

Erratum: Expression and Localization of Extracellular Matrix Metalloproteinase Inducer in Giant Cell Tumor of Bone.

2012 ◽  
Vol 113 (11) ◽  
pp. 3599-3599
Author(s):  
Andrew I.C. Si ◽  
Lin Huang ◽  
Jiake Xu ◽  
Shekhar–M Kumta ◽  
David Wood ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinase ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Extracellular Matrix Metalloproteinase Inducer

scholarly journals Tumorigenic Potential of Extracellular Matrix Metalloproteinase Inducer

2001 ◽  
Vol 158 (6) ◽  
pp. 1921-1928 ◽  
Author(s):  
Stanley Zucker ◽  
Michelle Hymowitz ◽  
Ellen E. Rollo ◽  
Richard Mann ◽  
Cathleen E. Conner ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Matrix Metalloproteinase ◽  
Extracellular Matrix Metalloproteinase Inducer ◽  
Tumorigenic Potential
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