High triglycerides, low HDL cholesterol and a low LDL cholesterol per apolipoprotein b ratio predict incident diabetes in patients with established coronary artery disease

2016 ◽  
Vol 252 ◽  
pp. e49
Author(s):  
C. Saely ◽  
P. Rein ◽  
A. Vonbank ◽  
D. Zanolin ◽  
A. Leiherer ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Apolipoprotein B ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Incident Diabetes ◽  
Established Coronary Artery Disease ◽  
Low Hdl ◽  
Artery Disease

scholarly journals Efficacy of Smartphone-Based Secondary Preventive Strategies in Coronary Artery Disease

2020 ◽  
Vol 14 ◽  
pp. 117954682092740
Author(s):  
Alexandra C Murphy ◽  
Georgina Meehan ◽  
Anoop N Koshy ◽  
Phelia Kunniardy ◽  
Omar Farouque ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiac Rehabilitation ◽  
Systolic Blood Pressure ◽  
Ldl Cholesterol ◽  
Meta Analysis ◽  
Established Coronary Artery Disease ◽  
Rehabilitation Programs ◽  
Artery Disease

Background: Cardiac rehabilitation programs provide a comprehensive framework for the institution of secondary preventive measures. Smartphone technology can provide a platform for the delivery of such programs and is a promising alternative to hospital-based services. However, there is limited evidence to date supporting this approach. Accordingly, we performed a systematic review and meta-analysis examining smartphone-based secondary prevention programs to traditional cardiac rehabilitation in patients with established coronary artery disease to ascertain the feasibility and effectiveness of these interventions. Methods: A systematic search of PubMed, MEDLINE, EMBASE, and the Cochrane Library was conducted. A meta-analysis was performed using a random-effects model with the outcomes of interest being 6-minute walk test (6MWT) distance, systolic blood pressure, low-density lipoprotein (LDL) cholesterol, and body mass index (BMI). Results: A total of 8 studies with 1120 patients across 5 countries were included in the quantitative analysis. Follow-up ranged from 6 weeks to 12 months. Five studies examined all patients post acute coronary syndrome, 2 studies examined only patients undergoing percutaneous coronary intervention, and 1 study examined all patients with a diagnosis of coronary artery disease, independent of intervention. Exercise capacity, as measured by the 6MWT, was significantly greater in the smartphone group (20.10 meters, 95% confidence interval [CI] 7.44-33.97; P < .001; I2 = 45.58). There was no significant difference in BMI reduction, systolic blood pressure, or LDL cholesterol levels between groups ( P value for all > .05). Conclusion: Publicly available smartphone-based cardiac rehabilitation programs are a convenient and easily disseminated intervention which show merit in exercise promotion in patients with established coronary artery disease. Further research is required to establish the clinical significance of recent findings favoring their use.

LDL-cholesterol and HDL-cholesterol concentrations decrease during the day

2002 ◽  
Vol 39 (3) ◽  
pp. 241-249 ◽  
Author(s):  
Takashi Miida ◽  
Yuichi Nakamura ◽  
Toru Mezaki ◽  
Osamu Hanyu ◽  
Seitaro Maruyama ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Arteries ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Normal Coronary Arteries ◽  
The Mean ◽  
Baseline Levels ◽  
Artery Disease ◽  
Homogeneous Assays

Background Homogenous assays for LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) are highly accurate, with little interference from triglyceride. Using these methods, we measured postprandial LDL-C and HDL-C. Earlier studies suggested a postprandial decrease in LDL-C. Methods To elucidate whether LDL-C and HDL-C decrease significantly during the day, we determined daily profiles of LDL-C and HDL-C using homogeneous assays in subjects with normal coronary arteries (N; n = 10), and subjects with coronary artery disease (CAD; n = 23). Results In both groups, LDL-C and HDL-C were significantly lower from after breakfast until midnight than they were before breakfast. The next morning, they returned to baseline levels. The mean reduction in LDL-C was 0·09--0·13 mmol/L in N and 0·05--0·20 mmol/L in CAD, while that in HDL-C was 0·02--0·06 mmol/L in N and 0·00--0·05 mmol/L in CAD. Conclusion LDL-C and HDL-C decrease significantly over the course of the day.

scholarly journals Neopterin as a Predictor of Total and Cardiovascular Mortality in Individuals Undergoing Angiography in the Ludwigshafen Risk and Cardiovascular Health Study

2009 ◽  
Vol 55 (6) ◽  
pp. 1135-1146 ◽  
Author(s):  
Tanja B Grammer ◽  
Dietmar Fuchs ◽  
Bernhard O Boehm ◽  
Bernhard R Winkelmann ◽  
Winfried Maerz
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiovascular Mortality ◽  
Estimated Glomerular Filtration Rate ◽  
Ldl Cholesterol ◽  
Smoking Status ◽  
Hdl Cholesterol ◽  
Hazard Ratios ◽  
St Elevation ◽  
Artery Disease

Abstract Background: Neopterin is produced upon activation of the cell-mediated immune response, and may be a novel risk marker for adverse outcomes resulting from coronary artery disease. Methods: We measured neopterin in 1801 study participants with and 511 without angiographic coronary artery disease. Rates of death were determined after a median follow-up of 8.0 years. Results: Estimated glomerular filtration rate and N-terminal pro-B–type natriuretic peptide (NT-proBNP) were the strongest predictors of neopterin. Neopterin was positively related to age and inversely related to LDL cholesterol, HDL cholesterol, and triglycerides. Use of lipid-lowering drugs lowered neopterin. Sex, body mass index, diabetes mellitus, hypertension, smoking status, Friesinger coronary score, and clinical instability at presentation were not associated with neopterin. Unlike C-reactive protein, neopterin was not increased in unstable angina pectoris, non–ST–elevation myocardial infarction, or ST-elevation myocardial infarction. In the third and fourth quartiles of neopterin, unadjusted hazard ratios for death from any cause were 1.94 (95% CI 1.44–2.61) and 3.32 (95% CI 2.53–4.30) compared to individuals in the first quartile, whereas hazard ratios for death from cardiovascular causes were 2.14 (95% CI 1.44–3.18) and 3.84 (95% CI 2.67–5.52), respectively. Neopterin remained predictive of total and cardiovascular mortality after adjusting for sex, age, body mass index, type 2 diabetes, hypertension, smoking status, LDL cholesterol, HDL cholesterol, triglycerides, estimated glomerular filtration rate, NT-proBNP, and clinical status at presentation, but NT-proBNP substantially weakened this association. Conclusions: Neopterin is an independent predictor of all-cause and cardiovascular mortality in individuals with or without stable coronary artery disease.

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