Isolated Lung Perfusion With Melphalan for Resectable Lung Metastases: A Phase I Clinical Trial

2004 ◽  
Vol 78 (6) ◽  
pp. 1919-1927 ◽  
Author(s):  
Jeroen M.H. Hendriks ◽  
Marco J.J.H. Grootenboers ◽  
Franz M.N.H. Schramel ◽  
Wim J. van Boven ◽  
Bernard Stockman ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Phase I ◽  
Lung Metastases ◽  
Lung Perfusion ◽  
Phase I Clinical Trial ◽  
Isolated Lung Perfusion ◽  
Isolated Lung

scholarly journals Long-term survival of a phase I clinical trial of isolated lung perfusion with melphalan for resectable lung metastases☆☆☆

2010 ◽  
Vol 38 (5) ◽  
pp. 621-627 ◽  
Author(s):  
Willem A. Den Hengst ◽  
Bart P. Van Putte ◽  
Jeroen M.H. Hendriks ◽  
Bernard Stockman ◽  
Wim-Jan P. van Boven ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Phase I ◽  
Lung Metastases ◽  
Lung Perfusion ◽  
Phase I Clinical Trial ◽  
Term Survival ◽  
Long Term Survival ◽  
Isolated Lung Perfusion ◽  
Isolated Lung

scholarly journals Multicenter Phase II Clinical Trial of Isolated Lung Perfusion in Patients With Lung Metastases

2019 ◽  
Vol 108 (1) ◽  
pp. 167-174 ◽  
Author(s):  
Paul A.J. Beckers ◽  
Michel I.M. Versteegh ◽  
Thomas J. Van Brakel ◽  
Jerry Braun ◽  
Bart Van Putte ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Phase Ii ◽  
Lung Metastases ◽  
Lung Perfusion ◽  
Phase Ii Clinical Trial ◽  
Multicenter Phase ◽  
Isolated Lung Perfusion ◽  
Isolated Lung

scholarly journals Phase II Multicenter Clinical Trial of Pulmonary Metastasectomy and Isolated Lung Perfusion with Melphalan in Patients with Resectable Lung Metastases

2014 ◽  
Vol 9 (10) ◽  
pp. 1547-1553 ◽  
Author(s):  
Willem A. den Hengst ◽  
Jeroen M.H. Hendriks ◽  
Bram Balduyck ◽  
Inez Rodrigus ◽  
Jan B. Vermorken ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Phase Ii ◽  
Lung Metastases ◽  
Lung Perfusion ◽  
Pulmonary Metastasectomy ◽  
Multicenter Clinical Trial ◽  
Isolated Lung Perfusion ◽  
Isolated Lung

Re-Evaluation of Toxicity and Long-Term Follow-Up of Isolated Lung Perfusion With Melphalan in Patients With Resectable Pulmonary Metastases: A Phase I and Extension Trial

2007 ◽  
Vol 83 (3) ◽  
pp. 1235-1236 ◽  
Author(s):  
Marco J.J.H. Grootenboers ◽  
Franz M.N.H. Schramel ◽  
Wim J. van Boven ◽  
Bart P. van Putte ◽  
Jeroen M.H. Hendriks ◽  
...  
Keyword(s):  
Phase I ◽  
Pulmonary Metastases ◽  
Lung Perfusion ◽  
Isolated Lung Perfusion ◽  
Isolated Lung ◽  
Long Term Follow Up ◽  
Extension Trial

scholarly journals Osteosarcoma with lung metastases

2019 ◽  
Vol 18 (4) ◽  
pp. 127-135 ◽  
Author(s):  
I. V. Zhilkin ◽  
D. G. Akhaladze ◽  
D. V. Litvinov ◽  
N. G. Uskova ◽  
M. V. Tihonova ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Pulmonary Metastases ◽  
Lung Metastases ◽  
Lung Perfusion ◽  
Surgical Approaches ◽  
Lung Lesions ◽  
Isolated Lung Perfusion ◽  
Isolated Lung ◽  
Metastatic Lung ◽  
Additional Option

Osteosarcoma is the bone tumor that most commonly affects children and adolescents. Before the introduction of polychemotherapy > 90% of patients with osteosarcoma died from pulmonary metastases. Despite development of new protocols of therapy in 30–40% of patients the disease is recurrent, more than 80% of them detected pulmonary metastasis. In this review we discussed the problems of detection of metastatic lung lesions and current approaches of methods of detection and marking of small sized metastatic lung lesions. An additional option in the treatment of lung metastases is intraoperative isolated lung perfusion, surgical approaches of which were also discussed.

Isolated lung perfusion with FUDR is an effective treatment for colorectal adenocarcinoma lung metastases in rats

1995 ◽  
Vol 59 (1) ◽  
pp. 205-208 ◽  
Author(s):  
Ng Bruce ◽  
Jeffrey T. Lenert ◽  
Benny Weksler ◽  
Jeffrey L. Port ◽  
Jennifer L. Ellis ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Colorectal Adenocarcinoma ◽  
Lung Metastases ◽  
Lung Perfusion ◽  
Isolated Lung Perfusion ◽  
Isolated Lung

scholarly journals Isolated Lung Perfusion as an Adjuvant Treatment of Colorectal Cancer Lung Metastases: A Preclinical Study in a Pig Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e59485 ◽  
Author(s):  
Pierre-Benoit Pagès ◽  
Olivier Facy ◽  
Pierre Mordant ◽  
Sylvain Ladoire ◽  
Guy Magnin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Adjuvant Treatment ◽  
Lung Metastases ◽  
Preclinical Study ◽  
Lung Perfusion ◽  
Pig Model ◽  
Isolated Lung Perfusion ◽  
Isolated Lung

Pharmacokinetics of isolated lung perfusion with melphalan for resectable pulmonary metastases, a phase I and extension trial

2007 ◽  
Vol 96 (7) ◽  
pp. 583-589 ◽  
Author(s):  
Marco JJ H. Grootenboers ◽  
Jeroen M.H. Hendriks ◽  
Wim J. van Boven ◽  
Catherijne A.J. Knibbe ◽  
Bart van Putte ◽  
...  
Keyword(s):  
Phase I ◽  
Pulmonary Metastases ◽  
Lung Perfusion ◽  
Isolated Lung Perfusion ◽  
Isolated Lung ◽  
Extension Trial
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