scholarly journals Redistribution of Gastric Blood Flow by Embolization of Gastric Arteries Before Esophagectomy

2011 ◽  
Vol 91 (5) ◽  
pp. 1546-1551 ◽  
Author(s):  
Michele Diana ◽  
Martin Hübner ◽  
Henri Vuilleumier ◽  
Pierre Bize ◽  
Alban Denys ◽  
...  
2021 ◽  
Vol 22 (10) ◽  
pp. 5211
Author(s):  
Dominik Bakalarz ◽  
Edyta Korbut ◽  
Zhengnan Yuan ◽  
Bingchen Yu ◽  
Dagmara Wójcik ◽  
...  

Hydrogen sulfide (H2S) is an endogenously produced molecule with anti-inflammatory and cytoprotective properties. We aimed to investigate for the first time if a novel, esterase-sensitive H2S-prodrug, BW-HS-101 with the ability to release H2S in a controllable manner, prevents gastric mucosa against acetylsalicylic acid-induced gastropathy on microscopic and molecular levels. Wistar rats were pretreated intragastrically with vehicle, BW-HS-101 (0.5–50 μmol/kg) or its analogue without the ability to release H2S, BW-iHS-101 prior to ASA administration (125 mg/kg, intragastrically). BW-HS-101 was administered alone or in combination with nitroarginine (L-NNA, 20 mg/kg, intraperitoneally) or zinc protoporphyrin IX (10 mg/kg, intraperitoneally). Gastroprotective effects of BW-HS-101 were additionally evaluated against necrotic damage induced by intragastrical administration of 75% ethanol. Gastric mucosal damage was assessed microscopically, and gastric blood flow was determined by laser flowmetry. Gastric mucosal DNA oxidation and PGE2 concentration were assessed by ELISA. Serum and/or gastric protein concentrations of IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-13, VEGF, GM-CSF, IFN-γ, TNF-α, and EGF were determined by a microbeads/fluorescent-based multiplex assay. Changes in gastric mucosal iNOS, HMOX-1, SOCS3, IL1-R1, IL1-R2, TNF-R2, COX-1, and COX-2 mRNA were assessed by real-time PCR. BW-HS-101 or BW-iHS-101 applied at a dose of 50 μmol/kg protected gastric mucosa against ASA-induced gastric damage and prevented a decrease in the gastric blood flow level. H2S prodrug decreased DNA oxidation, systemic and gastric mucosal inflammation with accompanied upregulation of SOCS3, and EGF and HMOX-1 expression. Pharmacological inhibition of nitric oxide (NO) synthase but not carbon monoxide (CO)/heme oxygenase (HMOX) activity by L-NNA or ZnPP, respectively, reversed the gastroprotective effect of BW-HS-101. BW-HS-101 also protected against ethanol-induced gastric injury formation. We conclude that BW-HS-101, due to its ability to release H2S in a controllable manner, prevents gastric mucosa against drugs-induced gastropathy, inflammation and DNA oxidation, and upregulate gastric microcirculation. Gastroprotective effects of this H2S prodrug involves endogenous NO but not CO activity and could be mediated by cytoprotective and anti-inflammatory SOCS3 and EGF pathways.


2000 ◽  
Vol 129 (2) ◽  
pp. 112-113 ◽  
Author(s):  
N. Ya. Zhelyaznek ◽  
G. E. Samonina ◽  
V. I. Sergeev ◽  
I. P. Ashmarin

2005 ◽  
Vol 21 (s2) ◽  
pp. 55-59 ◽  
Author(s):  
J. Hata ◽  
T. Kamada ◽  
N. Manabe ◽  
H. Kusunoki ◽  
D. Kamino ◽  
...  

1978 ◽  
Vol 16 (5) ◽  
pp. 815-823 ◽  
Author(s):  
John F. Gerkens ◽  
John G. Gerber ◽  
David G. Shand ◽  
Robert A. Branch

1967 ◽  
pp. 53-72 ◽  
Author(s):  
JACK RUDICK ◽  
WARREN G. GUNTHEROTH ◽  
LLOYD M. NYHUS

1965 ◽  
Vol 208 (2) ◽  
pp. 353-358 ◽  
Author(s):  
John P. Delaney ◽  
Eugene Grim

Total gastric blood flow and its distribution between antrum and corpus, and to the mucosa, submucosa, and muscularis of the corpus were measured in dogs under the influence of several agents known to affect gastric secretion. Histamine, infused intravenously or administered chronically in beeswax intramuscularly, produced increases in cardiac output, the fraction of the output going to the stomach and, hence, gastric tissue perfusion Epinephrine infusions also caused significant increases in cardiac output and gastric perfusion. Norepinephrine was the only agent that raised gastric vascular resistance; despite an increase in cardiac output, blood flow to the stomach fell. Neither intravenous secretin nor inspired 10% CO2 affected gastric perfusion. All agents except histamine increased the antrum/corpus perfusion ratio. Only norepinephrine altered the distribution of flow to the several tissues of the corpus; it caused a shift of flow from mucosa to muscle. The results provide no support for the frequently stated conclusion that gastric blood flow and secretion are closely related.


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