N-terminal region of human chemokine receptor CXCR3: Structural analysis of CXCR3(1–48) by experimental and computational studies

2014 ◽  
Vol 1844 (10) ◽  
pp. 1868-1880 ◽  
Author(s):  
R. Raucci ◽  
G. Colonna ◽  
A. Giovane ◽  
G. Castello ◽  
S. Costantini
Keyword(s):  
Structural Analysis ◽  
Chemokine Receptor ◽  
Terminal Region ◽  
Computational Studies

scholarly journals Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNT

FEBS Journal ◽  
2014 ◽  
Vol 281 (24) ◽  
pp. 5552-5566 ◽  
Author(s):  
Kaori Esaki ◽  
Sosuke Yoshinaga ◽  
Tatsuichiro Tsuji ◽  
Etsuko Toda ◽  
Yuya Terashima ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Terminal Region ◽  
Structural Basis ◽  
Chemokine Receptor Ccr2

Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists

2016 ◽  
Vol 59 (18) ◽  
pp. 8369-8380 ◽  
Author(s):  
Salvatore Di Maro ◽  
Anna Maria Trotta ◽  
Diego Brancaccio ◽  
Francesco Saverio Di Leva ◽  
Valeria La Pietra ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Cyclic Peptides ◽  
Terminal Region ◽  
Receptor Type ◽  
Cxcr4 Antagonists

scholarly journals Structural analysis of the starfish SALMFamide neuropeptides S1 and S2: The N-terminal region of S2 facilitates self-association

2014 ◽  
Vol 1844 (2) ◽  
pp. 358-365 ◽  
Author(s):  
Claire B. Otara ◽  
Christopher E. Jones ◽  
Nadine D. Younan ◽  
John H. Viles ◽  
Maurice R. Elphick
Keyword(s):  
Structural Analysis ◽  
Terminal Region ◽  
Self Association

scholarly journals Structural Analysis of the C-Terminal Region (Modules 18–20) of Complement Regulator Factor H (FH)

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e32187 ◽  
Author(s):  
Hugh P. Morgan ◽  
Haydyn D. T. Mertens ◽  
Mara Guariento ◽  
Christoph Q. Schmidt ◽  
Dinesh C. Soares ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Factor H ◽  
Terminal Region ◽  
Complement Regulator

Structural and dynamic properties of the C-terminal region of the Escherichia coli RNA chaperone Hfq: integrative experimental and computational studies

2017 ◽  
Vol 19 (31) ◽  
pp. 21152-21164 ◽  
Author(s):  
Bin Wen ◽  
Weiwei Wang ◽  
Jiahai Zhang ◽  
Qingguo Gong ◽  
Yunyu Shi ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Structural Dynamics ◽  
Functional Role ◽  
Dynamic Properties ◽  
Terminal Region ◽  
Computational Studies ◽  
Rna Chaperone

The structural dynamics of the C-terminal region of Hfq and its functional role were investigated by integrative experimental and computational studies.

Synthesis, X-Ray Structural Analysis and Computational Studies of a Novel Bis(2-Thienyl)Disulfide Derivative

2020 ◽  
pp. 1-9
Author(s):  
Yahia N. Mabkhot ◽  
Abdulrhman Alsayari ◽  
Abdullatif Bin Muhsinah ◽  
H. Algarni ◽  
Saied M. Soliman ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Computational Studies ◽  
X Ray

scholarly journals The N-terminal Region of the Atypical Chemokine Receptor ACKR2 Is a Key Determinant of Ligand Binding

2014 ◽  
Vol 289 (18) ◽  
pp. 12330-12342 ◽  
Author(s):  
Kay D. Hewit ◽  
Alasdair Fraser ◽  
Robert J. B. Nibbs ◽  
Gerard J. Graham
Keyword(s):  
Ligand Binding ◽  
Chemokine Receptor ◽  
Terminal Region

scholarly journals The preferred conformation of erythro- and threo-1,2-difluorocyclododecanes

2012 ◽  
Vol 8 ◽  
pp. 1271-1278 ◽  
Author(s):  
Yi Wang ◽  
Peer Kirsch ◽  
Tomas Lebl ◽  
Alexandra M Z Slawin ◽  
David O'Hagan
Keyword(s):  
Nmr Spectroscopy ◽  
Structural Analysis ◽  
Conformational Analysis ◽  
Computational Studies ◽  
X Ray ◽  
H Nmr

Cyclododecane adopts a square-like structure with corner and edge CH2 groups. In this study erythro- and threo-1,2-difluorocyclododecanes were prepared to explore whether the two vicinal C–F bonds, with different relative configurations, preferably locate at corner/edge or edge/edge locations. Conformational analysis comparing the diastereoisomers was explored by using a combination of 19F{1H} NMR spectroscopy, computational studies and, in the case of the threo isomer, X-ray structural analysis. In the lowest energy conformers for both diastereoisomers the vicinal C–F bonds are located corner/edge, rather than edge/edge. These structures avoid placing a C–F bond endo into the ring, and appear to benefit from C–CHF–C angle widening, which relaxes 1,4-H,H transannular interactions.

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