scholarly journals Anxiolytic effects of ethanol are partially related to a reduced expression of adenylyl cyclase 5 but not to μ-opioid receptor activation in rat nucleus accumbens

2012 ◽  
Vol 235 (2) ◽  
pp. 189-194 ◽  
Author(s):  
M. Morales-Mulia ◽  
E. Estrada-Camarena ◽  
M.I. Amaya ◽  
S. Mejía-Mauríes ◽  
I. Sollozo-Dupont ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Adenylyl Cyclase ◽  
Opioid Receptor ◽  
Receptor Activation ◽  
Μ Opioid Receptor ◽  
Rat Nucleus Accumbens

scholarly journals Opioid-Mediated Astrocyte–Neuron Signaling in the Nucleus Accumbens

Cells ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 586 ◽  
Author(s):  
Michelle Corkrum ◽  
Patrick E. Rothwell ◽  
Mark J. Thomas ◽  
Paulo Kofuji ◽  
Alfonso Araque
Keyword(s):  
Nucleus Accumbens ◽  
Opioid Receptor ◽  
Molecular Mechanisms ◽  
Brain Slices ◽  
Receptor Activation ◽  
Receptor Expression ◽  
Whole Cell Patch Clamp ◽  
Inward Currents ◽  
Μ Opioid Receptor ◽  
Patch Clamp Electrophysiology

Major hallmarks of astrocyte physiology are the elevation of intracellular calcium in response to neurotransmitters and the release of neuroactive substances (gliotransmitters) that modulate neuronal activity. While μ-opioid receptor expression has been identified in astrocytes of the nucleus accumbens, the functional consequences on astrocyte–neuron communication remains largely unknown. The present study has investigated the astrocyte responsiveness to μ-opioid signaling and the regulation of gliotransmission in the nucleus accumbens. Through the combination of calcium imaging and whole-cell patch clamp electrophysiology in brain slices, we have found that μ-opioid receptor activation in astrocytes elevates astrocyte cytoplasmic calcium and stimulates the release of the gliotransmitter glutamate, which evokes slow inward currents through the activation of neuronal N-methyl-D-aspartate (NMDA) receptors. These results indicate the existence of molecular mechanisms underlying opioid-mediated astrocyte–neuron signaling in the nucleus accumbens.

Histamine H3 receptor activation inhibits dopamine synthesis but not release or uptake in rat nucleus accumbens

2016 ◽  
Vol 106 ◽  
pp. 91-101 ◽  
Author(s):  
Guillermo Aquino-Miranda ◽  
Juan Escamilla-Sánchez ◽  
Raúl González-Pantoja ◽  
Antonio Bueno-Nava ◽  
José-Antonio Arias-Montaño
Keyword(s):  
Nucleus Accumbens ◽  
Receptor Activation ◽  
Dopamine Synthesis ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Rat Nucleus Accumbens ◽  
Histamine H3

scholarly journals κ-Opioid Receptor Activation Modifies Dopamine Uptake in the Nucleus Accumbens and Opposes the Effects of Cocaine

2000 ◽  
Vol 20 (24) ◽  
pp. 9333-9340 ◽  
Author(s):  
Alexis C. Thompson ◽  
Agustin Zapata ◽  
Joseph B. Justice ◽  
Roxanne A. Vaughan ◽  
Lawrence G. Sharpe ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Opioid Receptor ◽  
Receptor Activation ◽  
Dopamine Uptake

scholarly journals Author Correction: Structural insights into μ-opioid receptor activation

Nature ◽  
2020 ◽  
Vol 584 (7820) ◽  
pp. E16-E16
Author(s):  
Weijiao Huang ◽  
Aashish Manglik ◽  
A. J. Venkatakrishnan ◽  
Toon Laeremans ◽  
Evan N. Feinberg ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Activation ◽  
Μ Opioid Receptor ◽  
Structural Insights

scholarly journals μ-Opioid Receptor Activation Directly Modulates Intrinsically Photosensitive Retinal Ganglion Cells

Neuroscience ◽  
2019 ◽  
Vol 408 ◽  
pp. 400-417 ◽  
Author(s):  
Allison M. Cleymaet ◽  
Shannon K. Gallagher ◽  
Ryan E. Tooker ◽  
Mikhail Y. Lipin ◽  
Jordan M. Renna ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Opioid Receptor ◽  
Ganglion Cells ◽  
Receptor Activation ◽  
Retinal Ganglion ◽  
Μ Opioid Receptor
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