Identification of dynein light chain 2 as an interaction partner of p21-activated kinase 1

2005 ◽  
Vol 331 (1) ◽  
pp. 153-158 ◽  
Author(s):  
Jieqiong Lu ◽  
Qing Sun ◽  
Xiaoning Chen ◽  
Hanzhou Wang ◽  
Yun Hu ◽  
...  
Keyword(s):  
Light Chain ◽  
Interaction Partner ◽  
Dynein Light Chain ◽  
P21 Activated Kinase

scholarly journals Stage-specific Expression of Dynein Light Chain-1 and Its Interacting Kinase, p21-activated Kinase-1, in Rodent Testes: Implications in Spermiogenesis

2005 ◽  
Vol 53 (10) ◽  
pp. 1235-1243 ◽  
Author(s):  
Rui-An Wang ◽  
Ming Zhao ◽  
Marvin L. Meistrich ◽  
Rakesh Kumar
Keyword(s):  
Light Chain ◽  
Leydig Cells ◽  
Chromatin Condensation ◽  
Dynein Light Chain ◽  
Specific Expression ◽  
Regulatory Interactions ◽  
Dynein Motor ◽  
Complex Process ◽  
P21 Activated Kinase ◽  
Spermatogenic Epithelium

Mammalian spermatogenesis is a complex process involving regulatory interactions of many gene products. In this study, we found that dynein light chain-1 (DLC1), a component of the dynein motor complex, is highly expressed in mouse and rat testes. Immunohistochemically detectable levels of DLC1 are observed specifically in spermatids in steps 9–16 in distinct subcellular compartments: in steps 9–11, DLC1 is predominantly localized in the nucleus; in steps 12 and 13, it is found in both nucleus and cytoplasm; and in step 14–16, it is present exclusively in the cytoplasm. In addition, we found p21-activated kinase 1 (Pak1), a protein kinase that activates DLC1 by phosphorylating DLC1 at Serine 88, was also expressed during these stages of spermatogenesis. Pak1 was also expressed in Leydig cells, in preleptotene primary spermatocytes, and in round spermatids. The spermiogenic stage-specific expression of DLC1 suggests a role for DLC1 in chromatin condensation, spermatid shaping, and the final release of sperm from the spermatogenic epithelium. Further, Pak1 may also play a role in spermiogenesis by regulating DLC1 phosphorylation and, consequently, its function.

scholarly journals Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes

Cancer Cell ◽  
2004 ◽  
Vol 5 (6) ◽  
pp. 575-585 ◽  
Author(s):  
Ratna K Vadlamudi ◽  
Rozita Bagheri-Yarmand ◽  
Zhibo Yang ◽  
Seetharaman Balasenthil ◽  
Diep Nguyen ◽  
...  
Keyword(s):  
Light Chain ◽  
Dynein Light Chain ◽  
P21 Activated Kinase

scholarly journals Dynein Light Chain 1, a p21-Activated Kinase 1-Interacting Substrate, Promotes Cancerous Phenotypes

Cancer Cell ◽  
2013 ◽  
Vol 23 (3) ◽  
pp. 421-422
Author(s):  
Ratna K. Vadlamudi ◽  
Rozita Bagheri-Yarmand ◽  
Zhibo Yang ◽  
Seetharaman Balasenthil ◽  
Diep Nguyen ◽  
...  
Keyword(s):  
Light Chain ◽  
Dynein Light Chain ◽  
P21 Activated Kinase

Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes

Cancer Cell ◽  
2004 ◽  
Vol 6 (1) ◽  
pp. 101-101
Author(s):  
R VADLAMUDI ◽  
R BAGHERIYARMAND ◽  
Z YANG ◽  
S BALASENTHIL ◽  
D NGUYEN ◽  
...  
Keyword(s):  
Light Chain ◽  
Dynein Light Chain ◽  
P21 Activated Kinase

Cloning and Response to Gravity of The Silkworm Dynein Light Chain 8 Gene*

2009 ◽  
Vol 36 (3) ◽  
pp. 364-370
Author(s):  
Zong-Cheng TIAN ◽  
Ai-Rong QIAN ◽  
Hui-Yun XU ◽  
Sheng-Meng DI ◽  
Wei ZHANG ◽  
...  
Keyword(s):  
Light Chain ◽  
Dynein Light Chain

scholarly journals In silico whole-genome scanning of cancer-associated nonsynonymous SNPs and molecular characterization of a dynein light chain tumour variant

Oncogene ◽  
2005 ◽  
Vol 24 (40) ◽  
pp. 6133-6142 ◽  
Author(s):  
Abdel Aouacheria ◽  
Vincent Navratil ◽  
Wenyu Wen ◽  
Ming Jiang ◽  
Dominique Mouchiroud ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Light Chain ◽  
In Silico ◽  
Nonsynonymous Snps ◽  
Whole Genome ◽  
Dynein Light Chain ◽  
Genome Scanning
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