Effects of copper metabolism on neurological functions in Wistar and Wilson’s disease model rats

2006 ◽  
Vol 349 (3) ◽  
pp. 1079-1086 ◽  
Author(s):  
Noriko Fujiwara ◽  
Hiroyuki Iso ◽  
Nobue Kitanaka ◽  
Junichi Kitanaka ◽  
Hironobu Eguchi ◽  
...  
Keyword(s):  
Wilson’S Disease ◽  
Disease Model ◽  
Copper Metabolism ◽  
Wilson's Disease

The Need for Consensus About Liver Transplantation For Patients With Neuropsychiatric Wilson’s Disease

2021 ◽  
pp. 152692482110028
Author(s):  
Alberto Ferrarese ◽  
Patrizia Burra
Keyword(s):  
Liver Transplantation ◽  
Patient Outcomes ◽  
Wilson’S Disease ◽  
Therapeutic Option ◽  
Copper Metabolism ◽  
Wilson's Disease ◽  
Published Data ◽  
Neurological Improvement ◽  
Effective Therapeutic Option

Liver transplantation is considered an effective therapeutic option for Wilson’s disease (WD) patients with hepatic phenotype, since it removes the inherited defects of copper metabolism, and is associated with excellent graft and patient outcomes. The role of liver transplantation in WD patients with mixed hepatic and neuropsychiatric phenotype has remained controversial over time, mainly because of high post-operative complications, reduced survival and a variable, unpredictable rate of neurological improvement. This article critically discusses the recently published data in this field, focussing in more detail on isolated neuropsychiatric phenotype as a potential indication for liver transplantation in WD patients.

The ontogeny of liver copper metabolism in the guinea pig: Clues to the etiology of Wilson's disease

Hepatology ◽  
1986 ◽  
Vol 6 (3) ◽  
pp. 427-432 ◽  
Author(s):  
Surjit K. S. Srai ◽  
Andrew K. Burroughs ◽  
Bernard Wood ◽  
Owen Epstein
Keyword(s):  
Guinea Pig ◽  
Wilson’S Disease ◽  
Copper Metabolism ◽  
Wilson's Disease ◽  
Liver Copper

Mode of action of triethylenetetramine dihydrochloride on copper metabolism in Wilson's disease

1991 ◽  
Vol 83 (6) ◽  
pp. 364-366 ◽  
Author(s):  
R. Siegemund ◽  
J. Lößner ◽  
K. Günther ◽  
H.-J. Kühn ◽  
H. Bachmann
Keyword(s):  
Mode Of Action ◽  
Wilson’S Disease ◽  
Copper Metabolism ◽  
Wilson's Disease

scholarly journals A Case of Wilson’s Disease Presenting with Persistant Hemolysis

2021 ◽  
pp. 90-95
Author(s):  
Vrinda Vijayakumari ◽  
Kaliyannan Mayilananthi ◽  
Durga Krishnan ◽  
Ramprasath Anbazhagan ◽  
Gaurav Narayanan
Keyword(s):  
Autosomal Recessive ◽  
Wilson’S Disease ◽  
Copper Metabolism ◽  
Wilson's Disease ◽  
Interesting Case ◽  
Autosomal Recessive Disorders ◽  
Asymptomatic Patients ◽  
Hepatocellular Jaundice ◽  
Recessive Disorders ◽  
Psychiatric Manifestations

Wilson’s disease is one the rare autosomal recessive disorders of copper metabolism due to mutation in ATP7B gene located in chromosome 13. The mutations of this gene cause accumulation of copper in different tissues such as brain, liver, and eyes. The clinical presentation usually reflects this tissue distribution and varies from asymptomatic patients to those with hepatic or neuro-psychiatric manifestations. Here, we report an interesting case of Wilson’s disease which presented with mild persistent hemolysis leading to pre hepatic and post hepatic jaundice. He also had hepatocellular jaundice due to liver injury.

scholarly journals EFFECT OF ESTROGENS ON COPPER METABOLISM IN WILSON'S DISEASE*

1961 ◽  
Vol 40 (3) ◽  
pp. 445-453 ◽  
Author(s):  
James L. German ◽  
Alexander G. Bearn
Keyword(s):  
Wilson’S Disease ◽  
Copper Metabolism ◽  
Wilson's Disease
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