scholarly journals Ethanol inhibition of NMDA receptors in calcium-dependent and –independent modes

2020 ◽  
Vol 522 (4) ◽  
pp. 1046-1051
Author(s):  
Sergei I. Boikov ◽  
Dmitry A. Sibarov ◽  
Sergei M. Antonov
Keyword(s):  
Nmda Receptors ◽  
Ethanol Inhibition ◽  
Calcium Dependent

Fyn Tyrosine Kinase Reduces the Ethanol Inhibition of Recombinant NR1/NR2A but Not NR1/NR2B NMDA Receptors Expressed in HEK 293 Cells

2001 ◽  
Vol 72 (4) ◽  
pp. 1389-1393 ◽  
Author(s):  
Douglas L. Anders ◽  
Tana Blevins ◽  
Greg Sutton ◽  
Sheridan Swope ◽  
L. Judson Chandler ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Nmda Receptors ◽  
Ethanol Inhibition ◽  
Hek 293 ◽  
Hek 293 Cells ◽  
293 Cells ◽  
Fyn Tyrosine Kinase

Effect of the NR3 subunit on ethanol inhibition of recombinant NMDA receptors

2003 ◽  
Vol 987 (1) ◽  
pp. 117-121 ◽  
Author(s):  
C.Thetford Smothers ◽  
John J. Woodward
Keyword(s):  
Nmda Receptors ◽  
Ethanol Inhibition

Ethanol inhibition of stress-related tachycardia involves medullary NMDA receptors

1996 ◽  
Vol 310 (2-3) ◽  
pp. 145-153 ◽  
Author(s):  
Károly Varga ◽  
Gábor Lovas ◽  
Miklós Palkovits ◽  
George Kunos
Keyword(s):  
Nmda Receptors ◽  
Ethanol Inhibition

scholarly journals Ethanol inhibition of recombinant NMDA receptors is not altered by coexpression of CaMKII-α or CaMKII-β

Alcohol ◽  
2008 ◽  
Vol 42 (5) ◽  
pp. 425-432 ◽  
Author(s):  
Minfu Xu ◽  
L. Judson Chandler ◽  
John J. Woodward
Keyword(s):  
Nmda Receptors ◽  
Ethanol Inhibition

Calcium-Dependent Desensitization of NMDA Receptors

2018 ◽  
Vol 83 (10) ◽  
pp. 1173-1183 ◽  
Author(s):  
D. A. Sibarov ◽  
S. M. Antonov
Keyword(s):  
Nmda Receptors ◽  
Calcium Dependent

Calcium-dependent inactivation of synaptic NMDA receptors in hippocampal neurons

1995 ◽  
Vol 73 (1) ◽  
pp. 427-430 ◽  
Author(s):  
C. Rosenmund ◽  
A. Feltz ◽  
G. L. Westbrook
Keyword(s):  
Nmda Receptors ◽  
Intracellular Calcium ◽  
Hippocampal Neurons ◽  
Feedback Inhibition ◽  
Stimulus Frequency ◽  
Low Frequency ◽  
Similar Degree ◽  
Whole Cell ◽  
Calcium Dependent ◽  
Dependent Inactivation

1. We examined whether synaptically activated N-methyl-D-aspartate (NMDA) receptors are regulated by intracellular calcium in cultured hippocampal neurons by comparing excitatory postsynaptic currents (EPSCs) to the previously described calcium-dependent regulation of whole cell NMDA currents. Standard whole cell recording and fast application methods were used. 2. Low-frequency (0.2 Hz) stimulation of EPSCs in the presence of 2-amino-5-phosphonovalerate (AP5) evoked a constant amplitude alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated EPSC. On removal of AP5 in Ca(2+)-containing solutions, the amplitude of the slow NMDA receptor-mediated EPSC decreased by approximately 50% during the next 10 stimuli. The decrease in the EPSC was dependent on the extracellular calcium concentration and stimulus frequency, consistent with Ca(2+)-dependent desensitization/inactivation of postsynaptic NMDA receptors. A whole cell prepulse of NMDA (10 microM, 10 s) in Ca(2+)-containing solutions inhibited the slow EPSC to a similar degree. A series of slow EPSCs also produced Ca(2+)-dependent inactivation of whole cell NMDA currents evoked in low calcium solutions. 3. These results demonstrate that synaptic NMDA receptors are inactivated by intracellular calcium and that calcium entry through synaptically activated NMDA receptors is sufficient to provide feedback inhibition of the slow EPSC.

Synergistic effects of the peptide fragment D-NAPVSIPQ on ethanol inhibition of synaptic plasticity and NMDA receptors in rat hippocampus

Neuroscience ◽  
2005 ◽  
Vol 134 (2) ◽  
pp. 583-593 ◽  
Author(s):  
T.A. Zhang ◽  
A.W. Hendricson ◽  
M.F. Wilkemeyer ◽  
M.J. Lippmann ◽  
M.E. Charness ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Nmda Receptors ◽  
Synergistic Effects ◽  
Rat Hippocampus ◽  
Peptide Fragment ◽  
Ethanol Inhibition
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