Downregulation of CRX, a Group 3-specific oncogenic transcription factor, inhibits TGF-β/activin signaling in medulloblastoma cells

2021 ◽  
Vol 568 ◽  
pp. 76-82
Author(s):  
Shalaka Arun Masurkar ◽  
Akash Deogharkar ◽  
Harish Shrikrishna Bharambe ◽  
Neelam Vishwanath Shirsat
Keyword(s):  
Transcription Factor ◽  
Activin Signaling ◽  
Group 3 ◽  
Oncogenic Transcription Factor

scholarly journals Therapeutic Approaches Targeting PAX3-FOXO1 and Its Regulatory and Transcriptional Pathways in Rhabdomyosarcoma

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2798 ◽  
Author(s):  
Thanh Hung Nguyen ◽  
Frederic G. Barr
Keyword(s):  
Skeletal Muscle ◽  
Transcription Factor ◽  
Young Adults ◽  
Soft Tissue ◽  
Chromosomal Translocation ◽  
Murine Models ◽  
Therapeutic Approaches ◽  
Recent Developments ◽  
Children And Young Adults ◽  
Oncogenic Transcription Factor

Rhabdomyosarcoma (RMS) is a family of soft tissue cancers that are related to the skeletal muscle lineage and predominantly occur in children and young adults. A specific chromosomal translocation t(2;13)(q35;q14) that gives rise to the chimeric oncogenic transcription factor PAX3-FOXO1 has been identified as a hallmark of the aggressive alveolar subtype of RMS. PAX3-FOXO1 cooperates with additional molecular changes to promote oncogenic transformation and tumorigenesis in various human and murine models. Its expression is generally restricted to RMS tumor cells, thus providing a very specific target for therapeutic approaches for these RMS tumors. In this article, we review the recent understanding of PAX3-FOXO1 as a transcription factor in the pathogenesis of this cancer and discuss recent developments to target this oncoprotein for treatment of RMS.

scholarly journals Inhibitors of the Oncogenic Transcription Factor AP-1 fromPodocarpus latifolius

2011 ◽  
Vol 74 (3) ◽  
pp. 374-377 ◽  
Author(s):  
Krishna P. Devkota ◽  
Ranjala Ratnayake ◽  
Nancy H. Colburn ◽  
Jennifer A. Wilson ◽  
Curtis J. Henrich ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Oncogenic Transcription Factor

Structure, function, and dynamics of the dimerization and DNA-binding domain of oncogenic transcription factor v-Myc11Edited by P. E. Wright

2001 ◽  
Vol 307 (5) ◽  
pp. 1395-1410 ◽  
Author(s):  
Wolfgang Fieber ◽  
Martin L. Schneider ◽  
Theresia Matt ◽  
Bernhard Kräutler ◽  
Robert Konrat ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Dna Binding ◽  
Structure Function ◽  
Binding Domain ◽  
Factor V ◽  
Dna Binding Domain ◽  
Oncogenic Transcription Factor

scholarly journals Genetic lesions in MYC and STAT3 drive oncogenic transcription factor overexpression in plasmablastic lymphoma.

Haematologica ◽  
2020 ◽  
pp. haematol.2020.251579 ◽  
Author(s):  
Julia Garcia-Reyero ◽  
Nerea Martinez Magunacelaya ◽  
Sonia Gonzalez de Villambrosia ◽  
Sanam Loghavi ◽  
Angela Gomez Mediavilla ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Plasmablastic Lymphoma ◽  
Oncogenic Transcription Factor

scholarly journals An autocrine ActivinB mechanism drives TGF β/Activin signaling in Group 3 medulloblastoma

2019 ◽  
Vol 11 (8) ◽  
Author(s):  
Morgane Morabito ◽  
Magalie Larcher ◽  
Florence MG Cavalli ◽  
Chloé Foray ◽  
Antoine Forget ◽  
...  
Keyword(s):  
Activin Signaling ◽  
Group 3

scholarly journals CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3

Neoplasia ◽  
2020 ◽  
Vol 22 (1) ◽  
pp. 47-59 ◽  
Author(s):  
Susana P. Egusquiaguirre ◽  
Suhu Liu ◽  
Isidora Tošić ◽  
Kevin Jiang ◽  
Sarah R. Walker ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Oncogenic Transcription Factor
Sign in / Sign up

Export Citation Format

Share Document