A non-voltage-gated calcium channel with L-type characteristics activated by B cell receptor ligation

2003 ◽  
Vol 66 (10) ◽  
pp. 2001-2009 ◽  
Author(s):  
Gillian Grafton ◽  
Leanne Stokes ◽  
Kai-Michael Toellner ◽  
John Gordon
Keyword(s):  
Calcium Channel ◽  
B Cell ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel ◽  
Receptor Ligation

scholarly journals Down-regulation of CXCR4 and CD62L in Chronic Lymphocytic Leukemia Cells Is Triggered by B-Cell Receptor Ligation and Associated with Progressive Disease

2009 ◽  
Vol 69 (16) ◽  
pp. 6387-6395 ◽  
Author(s):  
Amalia Vlad ◽  
Pierre-Antoine Deglesne ◽  
Rémi Letestu ◽  
Stéphane Saint-Georges ◽  
Nathalie Chevallier ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Progressive Disease ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Down Regulation ◽  
Receptor Ligation

scholarly journals CD27 and CD40 Inhibit p53-independent Mitochondrial Pathways in Apoptosis of B Cells Induced by B Cell Receptor Ligation

2002 ◽  
Vol 277 (49) ◽  
pp. 46950-46958 ◽  
Author(s):  
Hidenori Hase ◽  
Yumiko Kanno ◽  
Hidefumi Kojima ◽  
Chikao Morimoto ◽  
Ko Okumura ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Receptor Ligation

scholarly journals B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells

2019 ◽  
Vol 116 (51) ◽  
pp. 25850-25859 ◽  
Author(s):  
Peter Csaba Huszthy ◽  
Ramakrishna Prabhu Gopalakrishnan ◽  
Johanne Tracey Jacobsen ◽  
Ole Audun Werner Haabeth ◽  
Geir Åge Løset ◽  
...  
Keyword(s):  
T Cells ◽  
B Cells ◽  
B Cell ◽  
Mhc Class Ii ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
B Cell Receptors ◽  
V Region ◽  
Receptor Ligation

The B cell receptors (BCRs) for antigen express variable (V) regions that are enormously diverse, thus serving as markers on individual B cells. V region-derived idiotypic (Id) peptides can be displayed as pId:MHCII complexes on B cells for recognition by CD4+T cells. It is not known if naive B cells spontaneously display pId:MHCII in vivo or if BCR ligation is required for expression, thereby enabling collaboration between Id+B cells and Id-specific T cells. Here, using a mouse model, we show that naive B cells do not express readily detectable levels of pId:MHCII. However, BCR ligation by Ag dramatically increases physical display of pId:MHCII, leading to activation of Id-specific CD4+T cells, extrafollicular T–B cell collaboration and some germinal center formation, and production of Id+IgG. Besides having implications for immune regulation, the results may explain how persistent activation of self-reactive B cells induces the development of autoimmune diseases and B cell lymphomas.

scholarly journals The Activation and Subsequent Regulatory Roles of Lyn and CD19 After B Cell Receptor Ligation are Independent

2002 ◽  
Vol 169 (12) ◽  
pp. 6910-6918 ◽  
Author(s):  
Yuekang Xu ◽  
Sarah-Jane E. Beavitt ◽  
Kenneth W. Harder ◽  
Margaret L. Hibbs ◽  
David M. Tarlinton
Keyword(s):  
B Cell ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Receptor Ligation

scholarly journals High-Affinity B Cell Receptor Ligation by Cognate Antigen Induces Cytokine-Independent Isotype Switching

2010 ◽  
Vol 184 (12) ◽  
pp. 6592-6599 ◽  
Author(s):  
Marian L. Turner ◽  
Lynn M. Corcoran ◽  
Robert Brink ◽  
Philip D. Hodgkin
Keyword(s):  
B Cell ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
Isotype Switching ◽  
High Affinity ◽  
Cognate Antigen ◽  
Receptor Ligation

scholarly journals MHC-Restricted Ig V Region-Driven T-B Lymphocyte Collaboration: B Cell Receptor Ligation Facilitates Switch to IgG Production

2004 ◽  
Vol 172 (12) ◽  
pp. 7476-7484 ◽  
Author(s):  
Ludvig A. Munthe ◽  
Audun Os ◽  
Michael Zangani ◽  
Bjarne Bogen
Keyword(s):  
B Cell ◽  
B Lymphocyte ◽  
Cell Receptor ◽  
B Cell Receptor ◽  
V Region ◽  
Receptor Ligation
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