Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints

2010 ◽  
Vol 79 (10) ◽  
pp. 1387-1397 ◽  
Author(s):  
Michal Sabisz ◽  
Józefa Węsierska-Gądek ◽  
Andrzej Skladanowski
Keyword(s):  
Hela Cells ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
P53 Pathway ◽  
Topoisomerase Ii Inhibitor ◽  
Mitotic Checkpoints ◽  
Compound C ◽  
Parp 1

Cellular Resistance to the Antitumor DNA Topoisomerase II Inhibitor S16020-2: Importance of the N-[2(Dimethylamino)ethyl]carbamoyl Side Chain

2000 ◽  
Vol 58 (4) ◽  
pp. 709-718 ◽  
Author(s):  
Sandrine Le Mée ◽  
Françoise Chaminade ◽  
Charlotte Delaporte ◽  
Judith Markovits ◽  
Jean-Marie Saucier ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Side Chain ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Cellular Resistance ◽  
Topoisomerase Ii Inhibitor

ChemInform Abstract: Podophyllotoxin Aza-Analogue, a Novel DNA Topoisomerase II Inhibitor.

ChemInform ◽  
2000 ◽  
Vol 31 (38) ◽  
pp. no-no
Author(s):  
Akira Iida ◽  
Masahiro Kano ◽  
Yoshihiro Kubota ◽  
Kenji Koga ◽  
Kiyoshi Tomioka
Keyword(s):  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Topoisomerase Ii Inhibitor
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