New approaches to invasive fungal infections in acute leukemia and hematopoietic stem cell transplant patients

2007 ◽  
Vol 20 (1) ◽  
pp. 99-107 ◽  
Author(s):  
John R. Wingard
2015 ◽  
Vol 47 (4) ◽  
pp. 218-224 ◽  
Author(s):  
Tiffany Simms-Waldrip ◽  
Galit Rosen ◽  
Karin Nielsen-Saines ◽  
Alan Ikeda ◽  
Berkley Brown ◽  
...  

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Dânia Sofia Marques ◽  
Carlos Pinho Vaz ◽  
Rosa Branca ◽  
Fernando Campilho ◽  
Catarina Lamelas ◽  
...  

Hematopoietic stem-cell transplant recipients are at increased risk of developing invasive fungal infections. This is a major cause of morbidity and mortality. We report a case of a 17-year-old male patient diagnosed with severe idiopathic acquired aplastic anemia who developed fungal pneumonitis due toRhizomucor sp.and rhinoencephalitis due toScedosporium apiospermum6 and 8 months after undergoing allogeneic hematopoietic stem-cell transplant from an HLA-matched unrelated donor. Discussion highlights risk factors for invasive fungal infections (i.e., mucormycosis and scedosporiosis), its clinical features, and the factors that must be taken into account to successfully treat them (early diagnosis, correction of predisposing factors, aggressive surgical debridement, and antifungal and adjunctive therapies).


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