Itaconic acid impairs the mitochondrial function by the inhibition of complexes II and IV and induction of the permeability transition pore opening in rat liver mitochondria

Biochimie ◽  
2020 ◽  
Vol 176 ◽  
pp. 150-157
Author(s):  
Konstantin N. Belosludtsev ◽  
Natalia V. Belosludtseva ◽  
Ekaterina A. Kosareva ◽  
Eugeny Yu. Talanov ◽  
Sergey V. Gudkov ◽  
...  
Keyword(s):  
Rat Liver ◽  
Itaconic Acid ◽  
Mitochondrial Function ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Permeability Transition Pore Opening ◽  
Pore Opening

scholarly journals ‘Pore’ formation is not required for the hydroperoxide-induced Ca2+ release from rat liver mitochondria

1992 ◽  
Vol 285 (1) ◽  
pp. 65-69 ◽  
Author(s):  
J Schlegel ◽  
M Schweizer ◽  
C Richter
Keyword(s):  
Rat Liver ◽  
Pore Formation ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Inner Membrane ◽  
Mitochondrial Inner Membrane ◽  
Specific Permeability ◽  
Specific Pathway

It has recently been suggested by several investigators that the hydroperoxide- and phosphate-induced Ca2+ release from mitochondria occurs through a non-specific ‘pore’ formed in the mitochondrial inner membrane. The aim of the present study was to investigate whether ‘pore’ formation actually is required for Ca2+ release. We find that the t-butyl hydroperoxide (tbh)-induced release is not accompanied by stimulation of sucrose entry into, K+ release from, and swelling of mitochondria provided re-uptake of the released Ca2+ (‘Ca2+ cycling’) is prevented. We conclude that (i) the tbh-induced Ca2+ release from rat liver mitochondria does not require ‘pore’ formation in the mitochondrial inner membrane, (ii) this release occurs via a specific pathway from intact mitochondria, and (iii) a non-specific permeability transition (‘pore’ formation) is likely to be secondary to Ca2+ cycling by mitochondria.

scholarly journals Methylmercury induces the opening of the permeability transition pore in rat liver mitochondria

2002 ◽  
Vol 89 (1-2) ◽  
pp. 159-162 ◽  
Author(s):  
Marcantonio Bragadin ◽  
Daniele Marton ◽  
Sabrina Manente ◽  
Mario Grasso ◽  
Antonio Toninello
Keyword(s):  
Rat Liver ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria

scholarly journals Functional activity of permeability transition pore in energized and deenergized rat liver mitochondria

2020 ◽  
Vol 92 (6) ◽  
pp. 63-76
Author(s):  
O. V. Akopova ◽  
◽  
L. I. Kolchinskaya ◽  
V. I. Nosar Kolchinskaya ◽  
◽  
...  
Keyword(s):  
Rat Liver ◽  
Functional Activity ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria
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