scholarly journals Functional activity of permeability transition pore in energized and deenergized rat liver mitochondria

2020 ◽  
Vol 92 (6) ◽  
pp. 63-76
Author(s):  
O. V. Akopova ◽  
◽  
L. I. Kolchinskaya ◽  
V. I. Nosar Kolchinskaya ◽  
◽  
...  
Keyword(s):  
Rat Liver ◽  
Functional Activity ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria

scholarly journals ‘Pore’ formation is not required for the hydroperoxide-induced Ca2+ release from rat liver mitochondria

1992 ◽  
Vol 285 (1) ◽  
pp. 65-69 ◽  
Author(s):  
J Schlegel ◽  
M Schweizer ◽  
C Richter
Keyword(s):  
Rat Liver ◽  
Pore Formation ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Inner Membrane ◽  
Mitochondrial Inner Membrane ◽  
Specific Permeability ◽  
Specific Pathway

It has recently been suggested by several investigators that the hydroperoxide- and phosphate-induced Ca2+ release from mitochondria occurs through a non-specific ‘pore’ formed in the mitochondrial inner membrane. The aim of the present study was to investigate whether ‘pore’ formation actually is required for Ca2+ release. We find that the t-butyl hydroperoxide (tbh)-induced release is not accompanied by stimulation of sucrose entry into, K+ release from, and swelling of mitochondria provided re-uptake of the released Ca2+ (‘Ca2+ cycling’) is prevented. We conclude that (i) the tbh-induced Ca2+ release from rat liver mitochondria does not require ‘pore’ formation in the mitochondrial inner membrane, (ii) this release occurs via a specific pathway from intact mitochondria, and (iii) a non-specific permeability transition (‘pore’ formation) is likely to be secondary to Ca2+ cycling by mitochondria.

scholarly journals Methylmercury induces the opening of the permeability transition pore in rat liver mitochondria

2002 ◽  
Vol 89 (1-2) ◽  
pp. 159-162 ◽  
Author(s):  
Marcantonio Bragadin ◽  
Daniele Marton ◽  
Sabrina Manente ◽  
Mario Grasso ◽  
Antonio Toninello
Keyword(s):  
Rat Liver ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria

scholarly journals The Effects of PK11195 and Protoporphyrin IX Can Modulate Chronic Alcohol Intoxication in Rat Liver Mitochondria under the Opening of the Mitochondrial Permeability Transition Pore

Cells ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1774
Author(s):  
Yulia Baburina ◽  
Irina Odinokova ◽  
Olga Krestinina
Keyword(s):  
Rat Liver ◽  
Mitochondrial Permeability Transition Pore ◽  
Mitochondrial Permeability Transition ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Alcohol Exposure ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Chronic Alcohol ◽  
Mitochondrial Permeability

Decades of active research have shown that mitochondrial dysfunction, the associated oxidative stress, impaired anti-stress defense mechanisms, and the activation of the proapoptotic signaling pathways underlie pathological changes in organs and tissues. Pathologies caused by alcohol primarily affect the liver. Alcohol abuse is the cause of many liver diseases, such as steatosis, alcoholic steatohepatitis, fibrosis, cirrhosis, and, potentially, hepatocellular cancer. In this study, the effect of chronic alcohol exposure on rat liver mitochondria was investigated. We observed an ethanol-induced increase in sensitivity to calcium, changes in the level of protein kinase Akt and GSK-3β phosphorylation, an induction of the mitochondrial permeability transition pore (mPTP), and strong alterations in the expression of mPTP regulators. Moreover, we also showed an enhanced effect of PK11195 and PPIX, on the parameters of the mPTP opening in rat liver mitochondria (RLM) isolated from ethanol-treated rats compared to the RLM from control rats. We suggest that the results of this study could help elucidate the mechanisms of chronic ethanol action on the mitochondria and contribute to the development of new therapeutic strategies for treating the effects of ethanol-related diseases.

Itaconic acid impairs the mitochondrial function by the inhibition of complexes II and IV and induction of the permeability transition pore opening in rat liver mitochondria

Biochimie ◽  
2020 ◽  
Vol 176 ◽  
pp. 150-157
Author(s):  
Konstantin N. Belosludtsev ◽  
Natalia V. Belosludtseva ◽  
Ekaterina A. Kosareva ◽  
Eugeny Yu. Talanov ◽  
Sergey V. Gudkov ◽  
...  
Keyword(s):  
Rat Liver ◽  
Itaconic Acid ◽  
Mitochondrial Function ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Permeability Transition Pore Opening ◽  
Pore Opening
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