Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies

2021 ◽  
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Author(s):  
Khaled R.A. Abdellatif ◽  
Eman K.A. Abdelall ◽  
Heba A.H. Elshemy ◽  
John N. Philoppes ◽  
Emad H.M. Hassanein ◽  
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Keyword(s):  
Molecular Modeling ◽  
Design Synthesis ◽  
Cyclooxygenase Inhibition ◽  
Drug Candidates ◽  
Modeling Studies ◽  
Molecular Modeling Studies ◽  
Cox 2 ◽  
Cardiovascular Evaluation ◽  
Cox 2 Inhibitors ◽  
Cardioprotective Drug

2‐Mercapto Benzthiazole Coupled Benzyl Triazoles as New COX‐2 Inhibitors: Design, Synthesis, Biological Testing and Molecular Modeling Studies

2019 ◽  
Vol 4 (37) ◽  
pp. 11081-11092
Author(s):  
Satyanarayana Yatam ◽  
Surender Singh Jadav ◽  
Krishna Prasadh Gundla ◽  
Kalyani Paidikondala ◽  
Ashok Reddy Ankireddy ◽  
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Molecular Modeling ◽  
Biological Testing ◽  
Design Synthesis ◽  
Modeling Studies ◽  
Molecular Modeling Studies ◽  
Cox 2 ◽  
Cox 2 Inhibitors

New Coumarin Derivatives as Potent Selective COX-2 Inhibitors: Synthesis, Anti-Inflammatory, QSAR, and Molecular Modeling Studies

2015 ◽  
Vol 348 (12) ◽  
pp. 875-888 ◽  
Author(s):  
Dina H. Dawood ◽  
Rasha Z. Batran ◽  
Thoraya A. Farghaly ◽  
Mohammed A. Khedr ◽  
Mohamed M. Abdulla
Keyword(s):  
Molecular Modeling ◽  
Coumarin Derivatives ◽  
Modeling Studies ◽  
Molecular Modeling Studies ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Cox 2 Inhibitors

scholarly journals Design, synthesis, antimicrobial activity and molecular modeling studies of novel benzofuroxan derivatives against Staphylococcus aureus

2009 ◽  
Vol 17 (8) ◽  
pp. 3028-3036 ◽  
Author(s):  
Salomão Dória Jorge ◽  
Andrea Masunari ◽  
Carlota Oliveira Rangel-Yagui ◽  
Kerly Fernanda Mesquita Pasqualoto ◽  
Leoberto Costa Tavares
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Molecular Modeling ◽  
Design Synthesis ◽  
Modeling Studies ◽  
Molecular Modeling Studies

Structure-Based Design, Synthesis and Molecular Modeling Studies of Thiazolyl Urea Derivatives as Novel Anti-Parkinsonian Agents

2012 ◽  
Vol 8 (6) ◽  
pp. 1057-1068
Author(s):  
Faizul Azam ◽  
Medapati Vijaya Vara Prasad ◽  
Neelaveni Thangavel ◽  
Anil Kumar Shrivastava ◽  
Govind Mohan
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Molecular Modeling ◽  
Urea Derivatives ◽  
Design Synthesis ◽  
Modeling Studies ◽  
Molecular Modeling Studies

Design, synthesis, cytotoxicity and molecular modeling studies of some novel fluorinated pyrazole-based heterocycles as anticancer and apoptosis-inducing agents

2018 ◽  
Vol 23 (1) ◽  
pp. 165-181 ◽  
Author(s):  
Eman A. Fayed ◽  
Sally I. Eissa ◽  
Ashraf H. Bayoumi ◽  
Nirvana A. Gohar ◽  
Ahmed B. M. Mehany ◽  
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Keyword(s):  
Molecular Modeling ◽  
Design Synthesis ◽  
Modeling Studies ◽  
Molecular Modeling Studies ◽  
Apoptosis Inducing Agents
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