cardioprotective drug
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Canagliflozin is a potential cardioprotective drug but exerts no significant effects on pirarubicin‑induced cardiotoxicity in rats

2021 ◽  
Vol 24 (4) ◽  
Author(s):  
Hongwei Shi ◽  
Qingfu Zeng ◽  
Yunjie Wei ◽  
Hong Yang ◽  
Heng Tang ◽  
...  
Keyword(s):  
Cardioprotective Drug

scholarly journals Human Pluripotent Stem Cells for Modeling of Anticancer Therapy-Induced Cardiotoxicity and Cardioprotective Drug Discovery

2021 ◽  
Vol 12 ◽  
Author(s):  
Wendy Keung ◽  
Yiu-Fai Cheung
Keyword(s):  
Risk Factors ◽  
Drug Discovery ◽  
Induced Pluripotent Stem Cell ◽  
Underlying Mechanism ◽  
Anticancer Therapy ◽  
Treatment Regimens ◽  
Increased Risk ◽  
Induced Pluripotent ◽  
Novel Drug ◽  
Cardioprotective Drug

Anticancer chemotherapies have been shown to produce severe side effects, with cardiotoxicity from anthracycline being the most notable. Identifying risk factors for anticancer therapy-induced cardiotoxicity in cancer patients as well as understanding its underlying mechanism is essential to improving clinical outcomes of chemotherapy treatment regimens. Moreover, cardioprotective agents against anticancer therapy-induced cardiotoxicity are scarce. Human induced pluripotent stem cell technology offers an attractive platform for validation of potential single nucleotide polymorphism with increased risk for cardiotoxicity. Successful validation of risk factors and mechanism of cardiotoxicity would aid the development of such platform for novel drug discovery and facilitate the practice of personalized medicine.

Optimizing PEG-Extended Apelin Analogues as Cardioprotective Drug Leads: Importance of the KFRR Motif and Aromatic Head Group for Improved Physiological Activity

2020 ◽  
Vol 63 (20) ◽  
pp. 12073-12082 ◽  
Author(s):  
Conrad Fischer ◽  
Tess Lamer ◽  
Kleinberg Fernandez ◽  
Mahmoud Gheblawi ◽  
Wang Wang ◽  
...  
Keyword(s):  
Physiological Activity ◽  
Head Group ◽  
Drug Leads ◽  
Cardioprotective Drug

Pirfenidone is a cardioprotective drug: Mechanisms of action and preclinical evidence

2020 ◽  
Vol 155 ◽  
pp. 104694 ◽  
Author(s):  
Alberto Aimo ◽  
Elisabetta Cerbai ◽  
Gianluca Bartolucci ◽  
Luigi Adamo ◽  
Andrea Barison ◽  
...  
Keyword(s):  
Mechanisms Of Action ◽  
Cardioprotective Drug

scholarly journals Pharmacokinetics of the Cardioprotective Drug Dexrazoxane and Its Active Metabolite ADR-925 with Focus on Cardiomyocytes and the Heart

2017 ◽  
Vol 364 (3) ◽  
pp. 433-446 ◽  
Author(s):  
Eduard Jirkovský ◽  
Anna Jirkovská ◽  
Jan Bureš ◽  
Jaroslav Chládek ◽  
Olga Lenčová ◽  
...  
Keyword(s):  
Active Metabolite ◽  
Cardioprotective Drug

scholarly journals Immobilization of cardioprotective drug phosphocreatine on a surface of nanoparticles of silica

2017 ◽  
Vol 917 ◽  
pp. 042009
Author(s):  
D V Korolev ◽  
N V Evreinova ◽  
E V Zakharova ◽  
K G Gareev ◽  
E B Naumysheva ◽  
...  
Keyword(s):  
Cardioprotective Drug

scholarly journals The impact of renal protection clinics on prescription of and adherence to cardioprotective drug therapy in chronic kidney disease patients

2017 ◽  
Vol 10 (3) ◽  
pp. 375-380
Author(s):  
Fanny Lepeytre ◽  
Héloise Cardinal ◽  
Lorraine Fradette ◽  
Jacobien Verhave ◽  
Marc Dorais ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Drug Therapy ◽  
Kidney Disease ◽  
Renal Protection ◽  
The Impact ◽  
Cardioprotective Drug

scholarly journals Association between higher rates of cardioprotective drug use and survival in patients on dialysis

2015 ◽  
Vol 11 (6) ◽  
pp. 824-843 ◽  
Author(s):  
Yuexin Tang ◽  
John M. Brooks ◽  
James B. Wetmore ◽  
Theresa I. Shireman
Keyword(s):  
Drug Use ◽  
Cardioprotective Drug
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