scholarly journals Role of the posterior mucosal defense barrier in portal hypertensive gastropathy

2021 ◽  
Vol 144 ◽  
pp. 112258
Author(s):  
Zhiqiang Yi ◽  
Minglin Zhang ◽  
Zhiyuan Ma ◽  
Biguang Tuo ◽  
Aimin Liu ◽  
...  
BIOCELL ◽  
2003 ◽  
Vol 27 (2) ◽  
pp. 163-172 ◽  
Author(s):  
Alicia B. Penissi ◽  
Mar韆 I. Rudolph ◽  
Ram髇 S. Piezzi
Keyword(s):  

2003 ◽  
Vol 284 (3) ◽  
pp. G399-G410 ◽  
Author(s):  
Sonlee D. West ◽  
Kenneth S. Helmer ◽  
Lily K. Chang ◽  
Yan Cui ◽  
George H. Greeley ◽  
...  

This study was done to examine the role of CCK in gastric mucosal defense and to assess the gastroprotective roles of nitric oxide and blood flow. In rats, the CCK secretagogues oleate and soybean trypsin inhibitor augmented gastric mucosal blood flow and prevented gastric injury from luminal irritants. Type A CCK receptor blockade negated CCK secretagogue-induced gastroprotection and exacerbated gastric injury from bile and ethanol but did not block adaptive cytoprotection. CCK secretagogue-induced gastroprotection and hyperemia were negated by nonselective nitric oxide synthase (NOS) inhibition ( N G-nitro-l-arginine methyl ester) but not by selective inducible NOS inhibition (aminoguanidine). Gastric mucosal calcium-dependent NOS activity, but not calcium-independent NOS activity, was increased following CCK and CCK secretagogues. The release of endogenous CCK plays a role in the intrinsic gastric mucosal defense system against injury from luminal irritants. The protective mechanism appears to involve increased production of nitric oxide from primarily the constitutive isoforms of NOS and a resultant increase in blood flow.


2004 ◽  
Vol 20 (6) ◽  
pp. 526-532 ◽  
Author(s):  
Jonathan D. Kaunitz ◽  
Yasutada Akiba
Keyword(s):  

Life Sciences ◽  
2001 ◽  
Vol 69 (25-26) ◽  
pp. 2993-3003 ◽  
Author(s):  
Brigitta M. Peskar ◽  
Nenad Maricic ◽  
Britta Gretzer ◽  
Rufina Schuligoi ◽  
Adrian Schmassmann

2018 ◽  
Vol 86 (March) ◽  
pp. 543-546
Author(s):  
AYMAN YOUSY, M.D. HANY SHEHAB, M.D. ◽  
KHALED RAGAB, M.Sc. MAGED EL-GHANAM, M.D. ◽  
MOHAMED GODA, M.D. HAYTHAM ABDALLA, M.D. ◽  
TAREK ABOUSHOUSHA, M.D. NOHA HELAL, M.D.

2009 ◽  
Vol 136 (5) ◽  
pp. A-154
Author(s):  
Tomasz Brzozowski ◽  
Peter C. Konturek ◽  
Alexandra Szlachcic ◽  
Agata Ptak-Belowska ◽  
Danuta Drozdowicz ◽  
...  

1998 ◽  
Vol 33 (2) ◽  
pp. 142-146 ◽  
Author(s):  
Masafumi Nakayama ◽  
Tadashi Iwao ◽  
Kazuhiko Oho ◽  
Atsushi Toyonaga ◽  
Kyuichi Tanikawa

1993 ◽  
Vol 14 (9) ◽  
pp. 430-435 ◽  
Author(s):  
Mary B. Mazanec ◽  
John G. Nedrud ◽  
Charlotte S. Kaetzel ◽  
Michael E. Lamm
Keyword(s):  

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