scholarly journals Functional Genomics of Attention-Deficit/Hyperactivity Disorder (ADHD) Risk Alleles on Dopamine Transporter Binding in ADHD and Healthy Control Subjects

2013 ◽  
Vol 74 (2) ◽  
pp. 84-89 ◽  
Author(s):  
Thomas J. Spencer ◽  
Joseph Biederman ◽  
Stephen V. Faraone ◽  
Bertha K. Madras ◽  
Ali A. Bonab ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Functional Genomics ◽  
Dopamine Transporter ◽  
Attention Deficit ◽  
Hyperactivity Disorder ◽  
Control Subjects ◽  
Risk Alleles ◽  
Healthy Control

Impaired and enhanced attentional function in children with attention deficit/hyperactivity disorder

2003 ◽  
Vol 33 (3) ◽  
pp. 481-489 ◽  
Author(s):  
J. KOSCHACK ◽  
H. J. KUNERT ◽  
G. DERICHS ◽  
G. WENIGER ◽  
E. IRLE
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Divided Attention ◽  
Statistical Significance ◽  
Neuropsychological Test ◽  
Control Group ◽  
Consecutive Series ◽  
Hyperactivity Disorder ◽  
Control Subjects ◽  
Attentional Tasks

Background. The symptom domain of inattention in attention deficit/hyperactivity disorder (ADHD) suggests that there are neuropsychological fields of attention in which subjects with ADHD express deficits. However, studies using differentiated neuropsychological attentional tests in ADHD are lacking.Method. A consecutive series of 35 subjects with ADHD aged 9–12 years were assessed on a computer-driven neuropsychological test battery for attentional functions. Their performance was classified according to the data of a normative sample of 187 healthy subjects aged 9–12 years, and compared with the performance of 35 matched healthy control subjects.Results. According to normative data, most ADHD subjects performed on all attentional measures within the normal range. Comparisons with the control group revealed that ADHD subjects reacted faster on all attentional tests, yielding statistical significance for the Go/No go test and the Divided Attention test. They also performed with significantly fewer errors on the Divided Attention test. On the Go/No go test, Visual Scanning test and Attentional Shift test ADHD subjects committed significantly more errors than control subjects.Conclusions. Our results suggest a differential pattern rather than a deficit pattern of attentional functions in ADHD. It is suggested that the more rapid response style of ADHD subjects leads to a more erroneous performance in self-paced attentional tasks and to a better performance in externally paced attentional tasks. However, neuropsychological tests of attention do not contribute to the clinical diagnosis of ADHD.

Sign in / Sign up

Export Citation Format

Share Document