Neural Effects of APOE4 Polymorphisms on Olfactory Processing in Aging

2021 ◽  
Vol 89 (9) ◽  
pp. S243
Author(s):  
Ayokunnumi Adenuga ◽  
Maria Hipolito ◽  
John VanMeter ◽  
Riya Seth ◽  
Narayan Rai ◽  
...  
Keyword(s):  
2020 ◽  
Vol 45 (7) ◽  
pp. 523-531
Author(s):  
Sara Touj ◽  
Samie Cloutier ◽  
Amel Jemâa ◽  
Mathieu Piché ◽  
Gilles Bronchti ◽  
...  

Abstract It is well established that early blindness results in enhancement of the remaining nonvisual sensory modalities accompanied by functional and anatomical brain plasticity. While auditory and tactile functions have been largely investigated, the results regarding olfactory functions remained less explored and less consistent. In the present study, we investigated olfactory function in blind mice using 3 tests: the buried food test, the olfactory threshold test, and the olfactory performance test. The results indicated better performance of blind mice in the buried food test and odor performance test while there was no difference in the olfactory threshold test. Using histological measurements, we also investigated if there was anatomical plasticity in the olfactory bulbs (OB), the most salient site for olfactory processing. The results indicated a larger volume of the OB driven by larger glomerular and granular layers in blind mice compared with sighted mice. Structural plasticity in the OB may underlie the enhanced olfactory performance in blind mice.


2003 ◽  
Vol 23 (12) ◽  
pp. 5370-5380 ◽  
Author(s):  
Tahira Farooqui ◽  
Kellie Robinson ◽  
Harald Vaessin ◽  
Brian H. Smith
Keyword(s):  

2018 ◽  
Vol 119 (2) ◽  
pp. 377-379 ◽  
Author(s):  
Jack Brooks ◽  
Jennifer Nicholas ◽  
Jennifer J. Robertson

Odor discrimination is a complex task that may be improved by increasing sampling time to facilitate evidence accumulation. However, experiments testing this phenomenon in olfaction have produced conflicting results. To resolve this disparity, Frederick et al. (Frederick DE, Brown A, Tacopina S, Mehta N, Vujovic M, Brim E, Amina T, Fixsen B, Kay LM. J Neurosci 37: 4416–4426, 2017) conducted experiments that suggest that sampling time and performance are task dependent. Their findings have implications for understanding olfactory processing and experimental design, specifically the effect of subtle differences in experimental design on study results.


2006 ◽  
Vol 29 (1) ◽  
pp. 163-201 ◽  
Author(s):  
Rachel I. Wilson ◽  
Zachary F. Mainen
Keyword(s):  

Author(s):  
Nicholas J. Strausfeld

A 1915 monograph by the Nobel Prize–winning neuroanatomist Santiago Ramón y Cajal and Domingo Sánchez y Sánchez, describing neurons and their organization in the optic lobes of insects, is now standard fare for those studying the microcircuitry of the insect visual system. The work contains prescient assumptions about possible functional arrangements, such as lateral interactions, centrifugal pathways, and the convergence of neurons onto wider dendritic trees, to provide central integration of information processed at peripheral levels of the system. This chapter will consider further indications of correspondence between the insect-crustacean and the vertebrate visual systems, with particular reference to the deep organization of the optic lobe’s third optic neuropil, the lobula, and part of the lateral forebrain (protocerebrum) that receives inputs from it. Together, the lobula and lateral protocerebrum suggest valid comparison with the visual cortex and olfactory centers.


Neuron ◽  
2003 ◽  
Vol 37 (5) ◽  
pp. 843-852 ◽  
Author(s):  
Carlos D. Brody ◽  
J.J. Hopfield

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