Prepulse inhibition vs cognitive modulation of the hand-blink reflex

The excitability of brainstem circuitries mediating defensive blinking in response to abrupt sensory inputs is continuously modulated by cortical areas, e.g., the hand-blink reflex (HBR), elicited by intense electrical median nerve stimulation, is enhanced when the stimulated hand is close to the face, with the behavioural purpose to optimize self-protection from increased threat. Here we investigated whether such cortically mediated HBR facilitation can be influenced by prepulse inhibition (PPI), which is known to occur entirely at the subcortical level. Twenty healthy volunteers underwent HBR recordings in five experimental conditions. In conditions 1 and 2, the stimulated hand was held either near (1) or far (2) from the face, respectively. In conditions 3 and 4, stimulation of the hand near the face was preceded by a peri-liminal prepulse to the index finger of the contralateral hand held either near (3) or far from the face (4). In condition 5, participants self-triggered the stimulus eliciting the HBR. We observed a reproducible HBR in 14 out of 20 participants and measured onset latency and area of the HBR in orbicularis oculi muscles bilaterally. HBR area decreased and latency increased in condition 2 relative to condition 1; HBR area decreased and latency increased markedly in condition 3, and somewhat less in condition 4, relative to conditions 1 and 2; self-stimulation (condition 5) also suppressed HBRs, but less than prepulses. These findings indicate that PPI of the HBR is more robust than the cognitive modulation exerted by top-down cortical projections. Possibly, an attentional shift to a prepulse may serve to reduce blinking in response to perturbation when it is convenient, in a given situation, not to interrupt ongoing visual processing.

Self-Regulation in Children with Neurodevelopmental Disorders “SR-MRehab: Un Colegio Emocionante”: A Protocol Study

Self-regulation refers to the ability to control and modulate behavior, and it can include both emotional and cognitive modulation. Children with neurodevelopmental disorders may show difficulties in self-regulation. The main objective of this study is to improve self-regulation skills in children between 6 and 11 years of age with neurodevelopmental disorders. Methodology: A randomized controlled trial will be conducted with the use of “SR-MRehab: Un colegio emocionante”, based on a non-immersive virtual reality system where virtual objects can be managed by children in a natural way using their hands. Children will be recruited from several schools of Granada (Spain) and they will be randomly allocated to two groups. An assessment will be conducted before and after the intervention and 24 weeks after the end of the intervention process. The experimental group will receive the intervention using virtual reality. The control group will receive a standard self-regulation program. Both interventions will be performed once a week for a total of 10 sessions. Changes in self-regulation, as well as the acceptability of technology with the use of SR-MRehab, will be evaluated. The results will be published and will provide evidence regarding the use of this type of intervention in children with neurodevelopmental disorders. Trial registration: Registered with code NCT04418921.

Towards a Dual Process Conception of the Selective Influence of Financial Literacy on Economic Behavior

While many studies examined the relationship between financial literacy and economic behavior, no fundamental theory that explains the mechanism by which financial knowledge influences behavior has yet emerged. This dissertation addresses this research gap by presenting a new theoretical model for financial literacy – the Cognitive Modulation of Economic Behavior [CMEB] that relates the availability of cognitive and mental resources with factors that influence individuals’ ability to rely on their knowledge: (i) the personal characteristics of the decision-maker, and (ii) the characteristics of the task that he or she wishes to perform. The influence of cognitive and mental resources, and task features, on the ability to apply financial knowledge when needed, was investigated in four different studies. Results indicate that the CMEB model explains the wide-ranging influence of financial literacy on economic behavior. By presenting a model that focuses on the influence of cognitive and mental resources on financial literacy-based behavior, this work expands our understating of the mechanism by which financial literacy operates. The CMEB model can serve as a basis for many theoretical advancements that are still needed in this field of research.

Emotional and Cognitive Modulation of Cybersickness: The Role of Pain Catastrophizing and Body Awareness

Objective: The goal was to investigate the influence of the tendency to catastrophize somatic symptoms and body awareness on motion-related sickness. Background: Influences of emotional and cognitive-evaluative processes on the genesis of motion sickness or cybersickness have rarely been investigated. Brain imaging studies showed activation during cybersickness, resembling the pattern found for pain processing. Two aspects often investigated in this context are pain catastrophizing and body awareness. The present two studies investigated the relationship of motion-related sickness to two tendencies involved in pain processing: pain catastrophizing and body awareness. Method: In the first study, 115 participants reported their motion sickness history, pain catastrophizing, and body awareness. In the second study, 40 participants were exposed to a virtual reality and reported their experience of cybersickness as well as their pain catastrophizing and body awareness. Results: Pain catastrophizing was positively correlated to motion sickness history and cybersickness. Body awareness did not show a linear effect on motion sickness history or cybersickness. However, the interaction effect of pain catastrophizing and body awareness was significant in both studies. Conclusion: Pain catastrophizing seems to have a detrimental effect on cybersickness symptoms. Body awareness moderated the relationship in the sense that the combination of high pain catastrophizing and low body awareness lead to the highest sickness levels. Application: Affective and cognitive modulation of cybersickness symptoms should be considered when exposing risk groups to motion-related adverse stimuli.