Hypoperfusion in response to epinephrine in local anaesthetics: Investigation of dependence on epinephrine concentration, spread of hypoperfusion and time to maximal cutaneous vasoconstriction

2017 ◽  
Vol 70 (3) ◽  
pp. 322-329 ◽  
Author(s):  
Rafi Sheikh ◽  
Khashayar Memarzadeh ◽  
Christian Torbrand ◽  
Jonas Blohmé ◽  
Malin Malmsjö
Keyword(s):  
Local Anaesthetics ◽  
Cutaneous Vasoconstriction ◽  
Epinephrine Concentration

Clinical Pharmacology of Local Anaesthetics

Anaesthesia ◽  
2000 ◽  
Vol 55 (9) ◽  
pp. 938-938
Author(s):  
K. R. Milligan
Keyword(s):  
Clinical Pharmacology ◽  
Local Anaesthetics

3-(s-Hydrindacen-4-yl)propylamines and 4-(s-hydrindacen-4-yl)butylamines; Synthesis and pharmacological screening

1981 ◽  
Vol 46 (8) ◽  
pp. 1800-1807 ◽  
Author(s):  
Zdeněk Vejdělek ◽  
Marie Bartošová ◽  
Miroslav Protiva
Keyword(s):  
Malonic Acid ◽  
Local Anaesthetics ◽  
Lithium Aluminium Hydride ◽  
Spasmolytic Activity ◽  
Lithium Aluminium ◽  
Malonic Acid Derivatives ◽  
Pharmacological Screening ◽  
Hydroxyethyl Piperazine

4-Chloromethyl-s-hydrindacene (VIIa) was transformed via the malonic acid derivatives VIIIa and IXa to the acid Xb which afforded in four steps the homological acid Xc. Reactions of chlorides of both acids (XIbc ) with dimethylamine, 1-methylpiperazine and 1-(2-hydroxyethyl)piperazine led to the amides XIIbc-XIVbc which were reduced with lithium aluminium hydride to the title compounds IVcd-VIcd. The amines obtained show central neuroleptic effects only in subtoxic doses; they are also potent local anaesthetics and have significant spasmolytic activity of the neurotropic as well as musculotropic type.

Interaction of local anaesthetics with cytochrome oxidase studied with fluorescence quenching

1985 ◽  
Vol 34 (5) ◽  
pp. 663-668 ◽  
Author(s):  
A.M. Casanovas ◽  
C. Labat ◽  
Ph. Courriere ◽  
J. Oustrin
Keyword(s):  
Fluorescence Quenching ◽  
Cytochrome Oxidase ◽  
Local Anaesthetics

Local anaesthetics

2013 ◽  
Vol 1449 (1) ◽  
pp. 22-22
Keyword(s):  
Local Anaesthetics
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