Design, synthesis and evaluation of progesterone–adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux

2010 ◽  
Vol 20 (10) ◽  
pp. 3165-3168 ◽  
Author(s):  
Waël Zeinyeh ◽  
Ghina Alameh ◽  
Sylvie Radix ◽  
Catherine Grenot ◽  
Charles Dumontet ◽  
...  
Keyword(s):  
Multidrug Efflux ◽  
Design Synthesis ◽  
P Glycoprotein ◽  
Bivalent Inhibitors

Progesterone–adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux: Design, synthesis, characterization and biological evaluation

Steroids ◽  
2012 ◽  
Vol 77 (12) ◽  
pp. 1177-1191 ◽  
Author(s):  
Waël Zeinyeh ◽  
Zahia Mahiout ◽  
Sylvie Radix ◽  
Thierry Lomberget ◽  
Axel Dumoulin ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Multidrug Efflux ◽  
Design Synthesis ◽  
P Glycoprotein ◽  
Bivalent Inhibitors

scholarly journals In silico studies of aminated thioxanthones: bacterial multidrug efflux pumps vs P-glycoprotein

2018 ◽  
Author(s):  
Emília Sousa ◽  
Fernando Durães ◽  
Andreia Palmeira ◽  
Madalena Pinto
Keyword(s):  
In Silico ◽  
Efflux Pumps ◽  
Multidrug Efflux ◽  
P Glycoprotein ◽  
Multidrug Efflux Pumps

Design, synthesis and evaluation of a novel series of inhibitors reversing P-glycoprotein-mediated multidrug resistance

2018 ◽  
Vol 92 (3) ◽  
pp. 1708-1716 ◽  
Author(s):  
Hesham Ghaleb ◽  
Huilan Li ◽  
Mutta Kairuki ◽  
Qianqian Qiu ◽  
Xinzhou Bi ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Design Synthesis ◽  
P Glycoprotein

Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness

2016 ◽  
Vol 88 (6) ◽  
pp. 820-831 ◽  
Author(s):  
Angela Stefanachi ◽  
Giuseppe Felice Mangiatordi ◽  
Piero Tardia ◽  
Domenico Alberga ◽  
Francesco Leonetti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Dft Studies ◽  
Design Synthesis ◽  
P Glycoprotein ◽  
Glycoprotein Inhibitors

scholarly journals Design, Synthesis, and Biological Evaluation of (S)-Valine Thiazole-Derived Cyclic and Noncyclic Peptidomimetic Oligomers as Modulators of Human P-Glycoprotein (ABCB1)

ChemBioChem ◽  
2013 ◽  
Vol 15 (1) ◽  
pp. 157-169 ◽  
Author(s):  
Satyakam Singh ◽  
Nagarajan Rajendra Prasad ◽  
Khyati Kapoor ◽  
Eduardo E. Chufan ◽  
Bhargav A. Patel ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
P Glycoprotein ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of novel triazole-core reversal agents against P-glycoprotein-mediated multidrug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 25819-25828 ◽  
Author(s):  
Bo Zhang ◽  
Tianxiao Zhao ◽  
Jie Zhou ◽  
Qianqian Qiu ◽  
Yuxuan Dai ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Click Chemistry ◽  
Biological Evaluation ◽  
Glycoprotein P ◽  
Design Synthesis ◽  
Reversal Agents ◽  
P Glycoprotein ◽  
Synthesis And Biological Evaluation

We designed and synthesized a novel series of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) inhibitors bearing a triazolphenethyl–tetrahydroisoquinoline scaffold through click chemistry.

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