Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness

2016 ◽  
Vol 88 (6) ◽  
pp. 820-831 ◽  
Author(s):  
Angela Stefanachi ◽  
Giuseppe Felice Mangiatordi ◽  
Piero Tardia ◽  
Domenico Alberga ◽  
Francesco Leonetti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Dft Studies ◽  
Design Synthesis ◽  
P Glycoprotein ◽  
Glycoprotein Inhibitors

scholarly journals Tetrahydroquinolinone derivatives as potent P-glycoprotein inhibitors: design, synthesis, biological evaluation and molecular docking analysis

MedChemComm ◽  
2017 ◽  
Vol 8 (10) ◽  
pp. 1919-1933 ◽  
Author(s):  
S. Ranjbar ◽  
O. Firuzi ◽  
N. Edraki ◽  
O. Shahraki ◽  
L. Saso ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Inhibitory Activity ◽  
Phenyl Ring ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Docking Analysis ◽  
P Glycoprotein ◽  
Glycoprotein Inhibitors ◽  
Molecular Docking Analysis

Tetrahydroquinolinones bearing a phenyl ring with electron-withdrawing substitution showed remarkable P-glycoprotein inhibitory activity and significantly increased rhodamine accumulation in MES-SA/DX5 cells.

Discovery of new pyrimidopyrrolizine/indolizine-based derivatives as P-glycoprotein inhibitors: design, synthesis, cytotoxicity, and MDR reversal activities

2021 ◽  
pp. 113403
Author(s):  
Ahmed M. Shawky ◽  
Ashraf N. Abdalla ◽  
Nashwa A. Ibrahim ◽  
Mohammed A.S. Abourehab ◽  
Ahmed M. Gouda
Keyword(s):  
Design Synthesis ◽  
P Glycoprotein ◽  
Glycoprotein Inhibitors ◽  
Mdr Reversal

Synthesis and biological evaluation of thiophenylbenzofuran derivatives as potential P-glycoprotein inhibitors

2020 ◽  
Vol 201 ◽  
pp. 112422
Author(s):  
Chin-Chuan Hung ◽  
Chien-Yu Chen ◽  
Yu-Chieh Wu ◽  
Chien-Fu Huang ◽  
Yu-Chun Huang ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
P Glycoprotein ◽  
Glycoprotein Inhibitors ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of chalcones as reversers of P-glycoprotein-mediated multidrug resistance

2019 ◽  
Vol 180 ◽  
pp. 350-366 ◽  
Author(s):  
Huanhuan Yin ◽  
Jingjing Dong ◽  
Yingchun Cai ◽  
Ximeng Shi ◽  
Hao Wang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
P Glycoprotein ◽  
Synthesis And Biological Evaluation

scholarly journals Design, Synthesis, and Biological Evaluation of (S)-Valine Thiazole-Derived Cyclic and Noncyclic Peptidomimetic Oligomers as Modulators of Human P-Glycoprotein (ABCB1)

ChemBioChem ◽  
2013 ◽  
Vol 15 (1) ◽  
pp. 157-169 ◽  
Author(s):  
Satyakam Singh ◽  
Nagarajan Rajendra Prasad ◽  
Khyati Kapoor ◽  
Eduardo E. Chufan ◽  
Bhargav A. Patel ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
P Glycoprotein ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of novel triazole-core reversal agents against P-glycoprotein-mediated multidrug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 25819-25828 ◽  
Author(s):  
Bo Zhang ◽  
Tianxiao Zhao ◽  
Jie Zhou ◽  
Qianqian Qiu ◽  
Yuxuan Dai ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Click Chemistry ◽  
Biological Evaluation ◽  
Glycoprotein P ◽  
Design Synthesis ◽  
Reversal Agents ◽  
P Glycoprotein ◽  
Synthesis And Biological Evaluation

We designed and synthesized a novel series of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) inhibitors bearing a triazolphenethyl–tetrahydroisoquinoline scaffold through click chemistry.

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