Synthesis and biological evaluation of novel C6-amino substituted 4-azasteroidal purine nucleoside analogues

2014 ◽  
Vol 24 (3) ◽  
pp. 973-975 ◽  
Author(s):  
Li-Hua Huang ◽  
Hong-De Xu ◽  
Zhen-Yu Yao ◽  
Yan-Guang Wang ◽  
Hong-Min Liu
Keyword(s):  
Biological Evaluation ◽  
Purine Nucleoside ◽  
Nucleoside Analogues ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of Iodinated and Fluorinated 9-(2-Hydroxypropyl) and 9-(2-Hydroxyethoxy)methyl Purine Nucleoside Analogues

2003 ◽  
Vol 46 (26) ◽  
pp. 5763-5772 ◽  
Author(s):  
Svjetlana Prekupec ◽  
Draženka Svedružić ◽  
Tatjana Gazivoda ◽  
Draginja Mrvoš-Sermek ◽  
Ante Nagl ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Purine Nucleoside ◽  
Nucleoside Analogues ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of a New Category of Purine-Nucleoside Analogues

2005 ◽  
Vol 23 (12) ◽  
pp. 1659-1664 ◽  
Author(s):  
Da-Liang Li ◽  
Hong-Li Bao ◽  
Qi-Tao Tan ◽  
Yu-Ping Tan ◽  
Tian-Pa You
Keyword(s):  
Biological Evaluation ◽  
Purine Nucleoside ◽  
Nucleoside Analogues ◽  
Synthesis And Biological Evaluation

scholarly journals Versatile synthesis and biological evaluation of novel 3’-fluorinated purine nucleosides

2015 ◽  
Vol 11 ◽  
pp. 2509-2520 ◽  
Author(s):  
Hang Ren ◽  
Haoyun An ◽  
Paul J Hatala ◽  
William C Stevens ◽  
Jingchao Tao ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Biological Evaluation ◽  
Purine Nucleoside ◽  
Coupling Reactions ◽  
Cell Growth Inhibition ◽  
Cross Coupling Reactions ◽  
Synthetic Strategy ◽  
Cancer Tumor ◽  
Purine Ring ◽  
Synthesis And Biological Evaluation

A unified synthetic strategy accessing novel 3'-fluorinated purine nucleoside derivatives and their biological evaluation were achieved. Novel 3’-fluorinated analogues were constructed from a common 3’-deoxy-3’-fluororibofuranose intermediate. Employing Suzuki and Stille cross-coupling reactions, fifteen 3’-fluororibose purine nucleosides 1–15 and eight 3’-fluororibose 2-chloro/2-aminopurine nucleosides 16–23 with various substituents at position 6 of the purine ring were efficiently synthesized. Furthermore, 3’-fluorine analogs of natural products nebularine and 6-methylpurine riboside were constructed via our convergent synthetic strategy. Synthesized nucleosides were tested against HT116 (colon cancer) and 143B (osteosarcoma cancer) tumor cell lines. We have demonstrated 3’-fluorine purine nucleoside analogues display potent tumor cell growth inhibition activity at sub- or low micromolar concentration.

ChemInform Abstract: Thiosugars. Part 9. Synthesis and Biological Evaluation of Some 4′-Thio-L-arabino Nucleoside Analogues.

ChemInform ◽  
2010 ◽  
Vol 32 (32) ◽  
pp. no-no
Author(s):  
Joern Wirsching ◽  
Juergen Voss ◽  
Gunadi Adiwidjaja ◽  
Jan Balzarini ◽  
Erik De Clercq
Keyword(s):  
Biological Evaluation ◽  
Nucleoside Analogues ◽  
Synthesis And Biological Evaluation

The Synthesis and Biological Evaluation of Novel Bridging Nucleoside Analogues

2002 ◽  
Vol 10 (2) ◽  
pp. 273-281 ◽  
Author(s):  
Cecilia H. Marzabadi ◽  
Richard W. Franck ◽  
Raymond F. Schinazi
Keyword(s):  
Biological Evaluation ◽  
Nucleoside Analogues ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of 2′,4′- and 3′,4′-bridged nucleoside analogues

2011 ◽  
Vol 19 (18) ◽  
pp. 5648-5669 ◽  
Author(s):  
K.C. Nicolaou ◽  
Shelby P. Ellery ◽  
Fatima Rivas ◽  
Karen Saye ◽  
Eric Rogers ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Nucleoside Analogues ◽  
Synthesis And Biological Evaluation
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