Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors

2017 ◽  
Vol 27 (18) ◽  
pp. 4399-4404 ◽  
Author(s):  
Sun Jun Park ◽  
Eunjin Kim ◽  
Miyoun Yoo ◽  
Joo-Youn Lee ◽  
Chi Hoon Park ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Cdk Inhibitors ◽  
Cyclin Dependent Kinase ◽  
Synthesis And Biological Evaluation

SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-PHENYLPYRIDO[2,3-D] PYRIMIDINE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (05) ◽  
pp. 50-58
Author(s):  
P. V Bhagwanrao ◽  
◽  
P. G. Ingole ◽  
S. R Butle
Keyword(s):  
Mcf7 Cell ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Cdk Inhibitors ◽  
Cyclin Dependent Kinase ◽  
Pyrimidine Derivatives ◽  
Structural Analogues ◽  
Novel Scaffold ◽  
Synthesis And Biological Evaluation ◽  
Breast Cancer Mcf7 Cell

We report a novel scaffold of 2-phenylpyrido[2,3-d]pyrimidine derivatives designed as structural analogues of dinaciclib. Sixteen derivatives were synthesised and evaluated for their CDK2/5 inhibition activity. Compounds 4-(2-(3-methoxybenzylidene)hydrazineyl)-2-phenylpyrido[2,3-d]pyrimidine (7i) and 4-(2-(3-nitrobenzylidene)hydrazineyl)-2-phenylpyrido[2,3-d]pyrimidine (7n) show promising IC50 and kinase selectivity. These compounds also show moderate anti-proliferative activity in the colon cancer HCT116 and breast cancer MCF7 cell lines. In molecular docking studies with CDK2, compounds 7i and 7nshow binding similar to dinaciclib.

Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors

2011 ◽  
Vol 19 (22) ◽  
pp. 6949-6965 ◽  
Author(s):  
Stuart C. Wilson ◽  
Butrus Atrash ◽  
Clare Barlow ◽  
Susan Eccles ◽  
Peter M. Fischer ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Cdk Inhibitors ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of a new series of imidazo[1,2-a]pyridines substituted as CDK inhibitors

2008 ◽  
Vol 6 (9) ◽  
pp. 142-143
Author(s):  
M.A. Martinez-Urbina ◽  
M.A. Vilchis-Reyes ◽  
A. Guzmán Sánchez ◽  
E. Diaz Torres
Keyword(s):  
Biological Evaluation ◽  
Cdk Inhibitors ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors

2008 ◽  
Vol 18 (7) ◽  
pp. 2292-2295 ◽  
Author(s):  
Jinho Lee ◽  
Hwangeun Choi ◽  
Kyoung-Hee Kim ◽  
Shinwu Jeong ◽  
Jong-Wook Park ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
Cyclin Dependent Kinase ◽  
Synthesis And Biological Evaluation

3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation

2005 ◽  
Vol 15 (9) ◽  
pp. 2221-2224 ◽  
Author(s):  
Ronghui Lin ◽  
Yanhua Lu ◽  
Steven K. Wetter ◽  
Peter J. Connolly ◽  
Ignatius J. Turchi ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
Cyclin Dependent Kinase ◽  
Synthesis And Biological Evaluation

ChemInform Abstract: Synthesis and Biological Evaluation of Selective and Potent Cyclin-Dependent Kinase Inhibitors.

ChemInform ◽  
2013 ◽  
Vol 44 (12) ◽  
pp. no-no
Author(s):  
Joannah N'gompaza-Diarra ◽  
Karima Bettayeb ◽  
Nohad Gresh ◽  
Laurent Meijer ◽  
Nassima Oumata
Keyword(s):  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
Cyclin Dependent Kinase ◽  
Synthesis And Biological Evaluation
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