Identification of a novel series of potent and selective CCR6 inhibitors as biological probes

2018 ◽  
Vol 28 (18) ◽  
pp. 3067-3072 ◽  
Author(s):  
Taisuke Tawaraishi ◽  
Nobuki Sakauchi ◽  
Kousuke Hidaka ◽  
Kyoko Yoshikawa ◽  
Toshitake Okui ◽  
...  
Keyword(s):  
Biological Probes

Recent advances on the synthesis of the antidepressant Paroxetine

2020 ◽  
Vol 27 ◽  
Author(s):  
Joana Santos ◽  
M. Fernanda Proença ◽  
Ana Joao Rodrigues ◽  
Patricia Patrício ◽  
H. Sofia Domingues
Keyword(s):  
Total Synthesis ◽  
Neurological Disorders ◽  
Serotonin Reuptake ◽  
Potent Inhibitor ◽  
Starting Material ◽  
Substitution Pattern ◽  
Biological Probes ◽  
Recent Advances ◽  
Treatment Of Depression ◽  
Made In

: Paroxetine is a potent inhibitor of serotonin reuptake and is widely prescribed for the treatment of depression and other neurological disorders. The synthesis of paroxetine and the possibility to prepare derivatives with a specific substitution pattern that may allow their use as biological probes, is an attractive topic especially for medicinal chemists engaged in neurosciences research. Considering the extensive work that was developed in the last decade on the total synthesis of paroxetine, this review summarizes the most important contributions in this field, organized according to the reagent that was used as starting material. Most of the methods allowed to prepare paroxetine in 4-9 steps with an overall yield of 9-66%. Despite the progress made in this area, there is still room for improvement, searching for new eco-friendly and sustainable synthetic alternatives.

scholarly journals Overriding Phthalate Decomposition When Exploring Mycophenolic Acid Intermediates as Selenium-Based ROS Biological Probes

ACS Omega ◽  
2018 ◽  
Vol 3 (10) ◽  
pp. 13474-13483 ◽  
Author(s):  
Mahesh B. Halle ◽  
Tesla Yudhistira ◽  
Kyung Jin Lee ◽  
Jae Hyuck Choi ◽  
Youngsam Kim ◽  
...  
Keyword(s):  
Mycophenolic Acid ◽  
Biological Probes

Water-dispersible near-infrared Ag2S nanoclusters with tunable fluorescence for bioimaging application

RSC Advances ◽  
2015 ◽  
Vol 5 (99) ◽  
pp. 80929-80932 ◽  
Author(s):  
Xiaofang Jia ◽  
Dan Li ◽  
Jing Li ◽  
Erkang Wang
Keyword(s):  
Aqueous Phase ◽  
Microwave Synthesis ◽  
Near Infrared ◽  
Cellular Imaging ◽  
Water Dispersible ◽  
Biological Probes ◽  
Tunable Emission

Water-dispersed ultrasmall Ag2S nanoclusters (NCs) are prepared directly in aqueous phase via a facile microwave synthesis. The resultant Ag2S NCs with tunable emission from visible to NIR region are promising biological probes for cellular imaging.

ANALOGS OF 2′,5′-OLIGOADENYLATES: BIOLOGICAL PROBES FOR THE ANTIVIRAL/ANTITUMOR STATE OF MAMMALIAN CELLS

1983 ◽  
pp. 147-179 ◽  
Author(s):  
Robert J. Suhadolnik ◽  
Yair Devash ◽  
Paul Doetsch ◽  
Earl E. Henderson ◽  
Joseph M. Wu ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Biological Probes

ChemInform Abstract: BIOLOGICAL PROBES PART 2, RING LABELED NICOTINAMIDE

1975 ◽  
Vol 6 (11) ◽  
pp. no-no
Author(s):  
T. A. BRYSON ◽  
J. C. WISOWATY ◽  
R. B. DUNLAP ◽  
R. R. FISHER ◽  
P. D. ELLIS
Keyword(s):  
Biological Probes

Self-assembled monolayer coating of biological probes to avoid protein adhesion

2006 ◽  
Vol 2 (1-2) ◽  
pp. 61-65 ◽  
Author(s):  
Greg Nusz ◽  
Eva Johannes ◽  
Nina Strömgren Allen ◽  
Hans D. Hallen
Keyword(s):  
Self Assembled Monolayer ◽  
Biological Probes ◽  
Protein Adhesion ◽  
Self Assembled
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