Inhibition of bone resorption by the cathepsin K inhibitor odanacatib is fully reversible

Bone ◽

10.1016/j.bone.2014.07.013 ◽

2014 ◽

Vol 67 ◽

pp. 269-280 ◽

Author(s):

Y. Zhuo ◽

J.-Y. Gauthier ◽

W.C. Black ◽

M.D. Percival ◽

L.T. Duong

Keyword(s):

Bone Resorption ◽

Cathepsin K ◽

Cathepsin K Inhibitor

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Effect of the selective cathepsin K inhibitor MIV-711 on bone resorption and cartilage degradation biomarkers and on knee joint pathology in dogs subjected to partial medial meniscectomy, an experimental model of osteoarthritis

Bone ◽

10.1016/j.bone.2012.02.598 ◽

2012 ◽

Vol 50 ◽

pp. S188-S189 ◽

Author(s):

E. Lindstrom⁎ ◽

L. Vrang ◽

S. Sedig ◽

Y. Terelius ◽

K. Wikström ◽

...

Keyword(s):

Bone Resorption ◽

Experimental Model ◽

Cathepsin K ◽

Cartilage Degradation ◽

Cathepsin K Inhibitor ◽

Joint Pathology ◽

Medial Meniscectomy ◽

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Morning vs evening dosing of the cathepsin K inhibitor ONO-5334: effects on bone resorption in postmenopausal women in a randomized, phase 1 trial

Osteoporosis International ◽

10.1007/s00198-015-3342-4 ◽

2015 ◽

Vol 27 (1) ◽

pp. 309-318 ◽

Author(s):

R. Eastell ◽

D.-J. Dijk ◽

M. Small ◽

A. Greenwood ◽

J. Sharpe ◽

...

Keyword(s):

Bone Resorption ◽

Postmenopausal Women ◽

Phase 1 ◽

Cathepsin K ◽

Phase 1 Trial ◽

Cathepsin K Inhibitor

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Effect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double-Blind, Randomized, Placebo-Controlled Phase I Studies

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2009.60 ◽

2009 ◽

Vol 86 (2) ◽

pp. 175-182 ◽

Author(s):

S A Stoch ◽

S Zajic ◽

J Stone ◽

D L Miller ◽

K Van Dyck ◽

...

Keyword(s):

Bone Resorption ◽

Phase I ◽

Postmenopausal Women ◽

Cathepsin K ◽

Double Blind ◽

Phase I Studies ◽

Cathepsin K Inhibitor

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Suppression of bone resorption from odanacatib, a cathepsin K inhibitor, in women with bone metastases from breast cancer, and the effect of concomitant anti-neoplastic treatment on efficacy: a 4-week, double-blind, randomized controlled trial.

10.1158/0008-5472.sabcs-1157 ◽

2009 ◽

Author(s):

AB Jensen ◽

C Wynne ◽

G Ramirez ◽

L Antje ◽

O Nina ◽

...

Keyword(s):

Breast Cancer ◽

Randomized Controlled Trial ◽

Bone Resorption ◽

Bone Metastases ◽

Controlled Trial ◽

Cathepsin K ◽

Double Blind ◽

Cathepsin K Inhibitor ◽

Randomized Controlled

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Serum and urine bone resorption markers and pharmacokinetics of the cathepsin K inhibitor ONO-5334 after ascending single doses in post menopausal women

British Journal of Clinical Pharmacology ◽

10.1111/j.1365-2125.2012.04307.x ◽

2012 ◽

Vol 74 (6) ◽

pp. 959-970 ◽

Author(s):

Shinichi Nagase ◽

Yoshitaka Hashimoto ◽

Maria Small ◽

Michiyo Ohyama ◽

Tomohiro Kuwayama ◽

...

Keyword(s):

Bone Resorption ◽

Cathepsin K ◽

Bone Resorption Markers ◽

Cathepsin K Inhibitor ◽

Menopausal Women ◽

Post Menopausal ◽

Serum And Urine

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Effects of novel cathepsin K inhibitor ONO-5334 on bone resorption markers: a study of four sustained release formulations with different pharmacokinetic patterns

Journal of Bone and Mineral Metabolism ◽

10.1007/s00774-013-0517-y ◽

2013 ◽

Vol 32 (4) ◽

pp. 447-454 ◽

Author(s):

Makoto Tanaka ◽

Yoshitaka Hashimoto ◽

Noboru Sekiya ◽

Naoki Honda ◽

Steve Deacon ◽

...

Keyword(s):

Bone Resorption ◽

Sustained Release ◽

Cathepsin K ◽

Bone Resorption Markers ◽

Cathepsin K Inhibitor

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Changes in micro-CT 3D bone parameters reflect effects of a potent cathepsin K inhibitor (SB-553484) on bone resorption and cortical bone formation in ovariectomized mice

Bone ◽

10.1016/j.bone.2007.01.010 ◽

2007 ◽

Vol 40 (5) ◽

pp. 1231-1237 ◽

Author(s):

Anbo Xiang ◽

Masahiro Kanematsu ◽

Sanjay Kumar ◽

Dennis Yamashita ◽

Toshihiko Kaise ◽

...

Keyword(s):

Bone Resorption ◽

Bone Formation ◽

Cortical Bone ◽

Cathepsin K ◽

Micro Ct ◽

Bone Parameters ◽

Cathepsin K Inhibitor ◽

Ovariectomized Mice

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Repeated oral administration of a cathepsin K inhibitor significantly suppresses bone resorption in exercising horses with evidence of increased bone formation and maintained bone turnover

Journal of Veterinary Pharmacology and Therapeutics ◽

10.1111/jvp.12368 ◽

2016 ◽

Vol 40 (4) ◽

pp. 327-334 ◽

Author(s):

H. Hussein ◽

J. Dulin ◽

L. Smanik ◽

W. T. Drost ◽

D. Russell ◽

...

Keyword(s):

Bone Resorption ◽

Bone Formation ◽

Bone Turnover ◽

Oral Administration ◽

Cathepsin K ◽

Cathepsin K Inhibitor

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A phase 1 pooled PK/PD analysis of bone resorption biomarkers for odanacatib, a Cathepsin K inhibitor

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-020-09699-9 ◽

2020 ◽

Vol 47 (5) ◽

pp. 473-484

Author(s):

Stefan Zajic ◽

S. Aubrey Stoch ◽

Jacqueline B. McCrea ◽

Rose Witter ◽

Ghassan N. Fayad ◽

...

Keyword(s):

Bone Resorption ◽

Phase 1 ◽

Cathepsin K ◽

Cathepsin K Inhibitor

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MIV-711, a highly selective cathepsin K inhibitor, reduces biomarkers of bone resorption and cartilage degradation in healthy subjects

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2014.02.376 ◽

2014 ◽

Vol 22 ◽

pp. S197 ◽

Author(s):

E. Lindstrom ◽

U. Grabowska ◽

M. Jerling ◽

C. Edenius

Keyword(s):

Bone Resorption ◽

Healthy Subjects ◽

Cathepsin K ◽

Cartilage Degradation ◽

Cathepsin K Inhibitor ◽

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