scholarly journals Electrophysiologic Characterization of a Complex hERG Channel Activator

2009 ◽  
Vol 96 (3) ◽  
pp. 485a
Author(s):  
Zhi Su ◽  
James Limberis ◽  
Andrew Souers ◽  
Philip Kym ◽  
Ann Mikhail ◽  
...  
Keyword(s):  
Herg Channel ◽  
Channel Activator

Electrophysiologic characterization of a novel hERG channel activator

2009 ◽  
Vol 77 (8) ◽  
pp. 1383-1390 ◽  
Author(s):  
Zhi Su ◽  
James Limberis ◽  
Andrew Souers ◽  
Philip Kym ◽  
Ann Mikhail ◽  
...  
Keyword(s):  
Herg Channel ◽  
Channel Activator

scholarly journals Characterization of a novel Ca2+‐activated Cl channel activator.

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Hyo Eun Lee ◽  
Jun‐Ho Lee ◽  
Minkyu Shin ◽  
Moochang Hong ◽  
Yangseok Kim ◽  
...  
Keyword(s):  
Cl Channel ◽  
Channel Activator

Characterization of hERG Channel Modulators in Optically Paced Human iPSC-Derived Cardiomyocytes Using Ultra-widefield Optopatch

2017 ◽  
Vol 88 ◽  
pp. 238 ◽  
Author(s):  
Vivian Hecht ◽  
John Ferrante ◽  
Nicholas Atwater ◽  
Kit Werley ◽  
Owen McManus ◽  
...  
Keyword(s):  
Herg Channel ◽  
Human Ipsc

Characterization of a novel K+ channel activator, EMD 52962, in electrophysiological and pharmacological experiments

1989 ◽  
Vol 414 (S1) ◽  
pp. S191-S191 ◽  
Author(s):  
J. E. De Peyer ◽  
I. Lues ◽  
R. Gericke ◽  
G. Häusler
Keyword(s):  
K Channel ◽  
Channel Activator

Identification of a Potent hERG Channel Activator with a Novel Mechanism of Action

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Sally J. Stoehr ◽  
Julie A. Dickson ◽  
Neil A. Castle ◽  
Aaron C. Gerlach
Keyword(s):  
Mechanism Of Action ◽  
Herg Channel ◽  
Channel Activator

scholarly journals Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System

2019 ◽  
Vol 117 (12) ◽  
pp. 2438-2454 ◽  
Author(s):  
Chon Lok Lei ◽  
Michael Clerx ◽  
David J. Gavaghan ◽  
Liudmila Polonchuk ◽  
Gary R. Mirams ◽  
...  
Keyword(s):  
High Throughput ◽  
Herg Channel ◽  
Channel Kinetics ◽  
Rapid Characterization

Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics

2002 ◽  
Vol 80 (8) ◽  
pp. 524-532 ◽  
Author(s):  
Dirk Isbrandt ◽  
Patrick Friederich ◽  
Anna Solth ◽  
Wilhelm Haverkamp ◽  
Andreas Ebneth ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Herg Channel ◽  
Channel Kinetics

scholarly journals The hERG channel activator, RPR260243, enhances protective IKr current early in the refractory period reducing arrhythmogenicity in zebrafish hearts

2020 ◽  
Vol 319 (2) ◽  
pp. H251-H261
Author(s):  
Yu Patrick Shi ◽  
ZhaoKai Pang ◽  
Ravichandra Venkateshappa ◽  
Marvin Gunawan ◽  
Jacob Kemp ◽  
...  
Keyword(s):  
Ventricular Arrhythmia ◽  
Refractory Period ◽  
Therapeutic Potential ◽  
Herg Channel ◽  
Heart Model ◽  
Long Qt ◽  
Significant Interest ◽  
Qt Syndrome ◽  
Zebrafish Heart ◽  
Channel Activator

hERG channel dysfunction causes long QT syndrome and arrhythmia. Activator compounds have been of significant interest due to their therapeutic potential. We used the whole organ zebrafish heart model to demonstrate the antiarrhythmic benefit of the hERG activator, RPR260243. The activator abbreviated APD and increased refractoriness, the combined effect of which rescued induced ventricular arrhythmia. Our findings show that the targeted slowing of hERG channel deactivation and enhancement of protective currents caused by the RPR260243 activator may provide an effective antiarrhythmic approach.

scholarly journals Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence

2019 ◽  
Vol 117 (12) ◽  
pp. 2455-2470 ◽  
Author(s):  
Chon Lok Lei ◽  
Michael Clerx ◽  
Kylie A. Beattie ◽  
Dario Melgari ◽  
Jules C. Hancox ◽  
...  
Keyword(s):  
Temperature Dependence ◽  
Herg Channel ◽  
Channel Kinetics ◽  
Rapid Characterization
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