scholarly journals The Role of the Membrane-Water Interface in Co-Translational Membrane Protein Folding

2021 ◽  
Vol 120 (3) ◽  
pp. 134a
Author(s):  
Jan Steinkühler ◽  
Sharon M. Loverde ◽  
Neha P. Kamat
Keyword(s):  
Protein Folding ◽  
Membrane Protein ◽  
Water Interface ◽  
Membrane Protein Folding

scholarly journals The expanding role of the ER translocon in membrane protein folding

2007 ◽  
Vol 179 (7) ◽  
pp. 1333-1335 ◽  
Author(s):  
William R. Skach
Keyword(s):  
Protein Folding ◽  
Membrane Proteins ◽  
Membrane Protein ◽  
Functional Organization ◽  
Conducting Channel ◽  
Membrane Protein Folding ◽  
Protein Biogenesis ◽  
Insight Into ◽  
Er Membrane

Eukaryotic polytopic membrane proteins are cotranslationally inserted into the ER membrane by a multisubunit protein-conducting channel called the Sec61 translocon. Although most major translocon components have been identified and reconstituted, their stoichiometry and functional organization remain unknown. This has led to speculative and sometimes conflicting models describing how multiple transmembrane (TM) segments might be oriented and integrated during nascent polytopic protein biogenesis. Kida et al. (see p. 1441 of this issue) shed new insight into this area by demonstrating that functional translocons exhibit a remarkable flexibility by simultaneously accommodating at least two hydrophilic translocating peptides that are separated by multiple hydrophobic TMs. These surprising findings support an expanded role for the translocon in membrane protein biogenesis and require reassessment of current views based on a single small functional pore.

scholarly journals Applications of Single-Molecule Methods to Membrane Protein Folding Studies

2018 ◽  
Vol 430 (4) ◽  
pp. 424-437 ◽  
Author(s):  
Robert E. Jefferson ◽  
Duyoung Min ◽  
Karolina Corin ◽  
Jing Yang Wang ◽  
James U. Bowie
Keyword(s):  
Protein Folding ◽  
Membrane Protein ◽  
Single Molecule ◽  
Membrane Protein Folding

scholarly journals In-Situ Observation of Membrane Protein Folding during Cell-Free Expression

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0151051 ◽  
Author(s):  
Axel Baumann ◽  
Silke Kerruth ◽  
Jörg Fitter ◽  
Georg Büldt ◽  
Joachim Heberle ◽  
...  
Keyword(s):  
Protein Folding ◽  
Membrane Protein ◽  
Free Expression ◽  
In Situ Observation ◽  
Membrane Protein Folding

Membrane Protein Folding and Stability

2021 ◽  
pp. 137-160
Author(s):  
Stephen H. White ◽  
Gunnar von Heijne ◽  
Donald M. Engelman
Keyword(s):  
Protein Folding ◽  
Membrane Protein ◽  
Membrane Protein Folding

scholarly journals 2P103 Direct monitoring of membrane protein folding process during in-vitro expression by Surface Enhanced IR spectroscopy(03. Membrane proteins,Poster)

2013 ◽  
Vol 53 (supplement1-2) ◽  
pp. S176
Author(s):  
Kenichi Ataka ◽  
Joachim Heberle ◽  
Axel Baumann ◽  
Silke Kerruth ◽  
Ramona Schlesinger ◽  
...  
Keyword(s):  
Protein Folding ◽  
Membrane Proteins ◽  
Ir Spectroscopy ◽  
Membrane Protein ◽  
In Vitro Expression ◽  
Folding Process ◽  
Membrane Protein Folding ◽  
Surface Enhanced
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