Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line

2007 ◽  
Vol 258 (2) ◽  
pp. 181-188 ◽  
Author(s):  
Marzia B. Gariboldi ◽  
Raffaella Ravizza ◽  
Roberta Molteni ◽  
Domenico Osella ◽  
Elisabetta Gabano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Metastatic Breast ◽  
Cancer Cell Line ◽  
Metastatic Breast Cancer Cell

3,6-dichloro-1,2,4,5-Tetrazine Assayed at High Doses in the Metastatic Breast Cancer Cell Line MDA-MB-231 Reduces Cell Numbers and Induces Apoptosis

2020 ◽  
Vol 16 (4) ◽  
pp. 546-550 ◽  
Author(s):  
Mohamed Abdelkarim ◽  
Khaoula Ben Younes ◽  
Ines Limam ◽  
Refka Guermazi ◽  
Amel Ben Ammaar ElGaaied ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Metastatic Breast ◽  
Cancer Cell Line ◽  
Metastatic Breast Cancer Cell

Background: The lack of treatment options for patients with chemotherapy-resistant cancers is pushing the field toward the development of new therapies. 1,2,4,5-tetrazine derivatives are a class of heterocyclic compounds that exhibit a broad spectrum of antitumor activities. Objective: The purpose of this study was to assess the biological activity of four s-tetrazine derivatives by substitution of two chloride atom of 3,6-dichloro-1,2,4,5-tetrazine with long hydrophobic side chains. Methods: We analyzed the anti-proliferative effects of four s-tetrazine derivatives with MTT assay and their pro-apoptotic effect with AV/ IP flow cytometry analysis and Hoechst 33342 staining. Results: We demonstrated that 3,6-dichloro-1,2,4,5-tetrazine (compound (1)) has a cytotoxic effect and induces apoptosis. Conclusion: 3,6-dichloro-1,2,4,5-tetrazine presents a new cytotoxic drug against metastatic breast cancer cell line MDA-MB-231 in vitro.

scholarly journals Cytotoxic and pro-apoptotic effects of Abrus precatorius L. on human metastatic breast cancer cell line, MDA-MB-231

2012 ◽  
Vol 65 (3) ◽  
pp. 407-417 ◽  
Author(s):  
Mohammed Shafi Sofi ◽  
M. K. Sateesh ◽  
Mohsin Bashir ◽  
G. Harish ◽  
T. R. Lakshmeesha ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Metastatic Breast ◽  
Cancer Cell Line ◽  
Abrus Precatorius ◽  
Apoptotic Effects
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