Matrix Metalloproteinase-9 Is a Marker of Heart Failure After Acute Myocardial Infarction

2006 ◽  
Vol 12 (1) ◽  
pp. 66-72 ◽  
Author(s):  
Daniel R. Wagner ◽  
Charles Delagardelle ◽  
Isabelle Ernens ◽  
Didier Rouy ◽  
Michel Vaillant ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

Serum matrix metalloproteinase-9 levels in patients with acute myocardial infarction

2009 ◽  
Vol 42 (4-5) ◽  
pp. 342
Author(s):  
Savas Guzel ◽  
Ozden Serin ◽  
Guzin Yilmaz ◽  
Eda Celik Guzel ◽  
Guvenc Guvenen
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

scholarly journals Increases in Interleukin-6 and Matrix Metalloproteinase-9 in the Infarct-Related Coronary Artery of Acute Myocardial Infarction

2004 ◽  
Vol 68 (5) ◽  
pp. 451-454 ◽  
Author(s):  
Hiroshi Funayama ◽  
San-e Ishikawa ◽  
Norifumi Kubo ◽  
Takuji Katayama ◽  
Takanori Yasu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Matrix Metalloproteinase ◽  
Interleukin 6 ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

scholarly journals Myocardial Injury Promotes Matrix Metalloproteinase-9 Activity in the Renal Cortex in Preclinical Models of Acute Myocardial Infarction

2021 ◽  
Author(s):  
Xiaoying Qiao ◽  
Shreyas Bhave ◽  
Lija Swain ◽  
Elric Zweck ◽  
Lara Reyelt ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Matrix Metalloproteinase ◽  
Renal Cortex ◽  
Myocardial Infarct ◽  
Ischemia Reperfusion ◽  
Matrix Metalloproteinase 9 ◽  
Myocardial Infarct Size ◽  
Va Ecmo ◽  
Metalloproteinase 9

AbstractNew mechanistic insight into how the kidney responds to cardiac injury during acute myocardial infarction (AMI) is required. We hypothesized that AMI promotes inflammation and matrix metalloproteinase-9 (MMP9) activity in the kidney and studied the effect of initiating an Impella CP or veno-arterial extracorporeal membrane oxygenation (VA-ECMO) before coronary reperfusion during AMI. Adult male swine were subjected to coronary occlusion and either reperfusion (ischemia-reperfusion; IR) or support with either Impella or VA-ECMO before reperfusion. IR and ECMO increased while Impella reduced levels of MMP-9 in the myocardial infarct zone, circulation, and renal cortex. Compared to IR, Impella reduced myocardial infarct size and urinary KIM-1 levels, but VA-ECMO did not. IR and VA-ECMO increased pro-fibrogenic signaling via transforming growth factor-beta and endoglin in the renal cortex, but Impella did not. These findings identify that AMI increases inflammatory activity in the kidney, which may be attenuated by Impella support.

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