Optimization of a continuous fermentation process producing 1,3-propane diol with Hopf singularity and unstable operating points as constraints

2014 ◽  
Vol 116 ◽  
pp. 668-681 ◽  
Author(s):  
Hangzhou Wang ◽  
Nan Zhang ◽  
Tong Qiu ◽  
Jinsong Zhao ◽  
Xiaorong He ◽  
...  
Keyword(s):  
Fermentation Process ◽  
Continuous Fermentation ◽  
Operating Points

scholarly journals Modeling and Parameter Identification Involving 3-Hydroxypropionaldehyde Inhibitory Effects in Glycerol Continuous Fermentation

2012 ◽  
Vol 2012 ◽  
pp. 1-18
Author(s):  
Zhaohua Gong ◽  
Chongyang Liu ◽  
Yongsheng Yu
Keyword(s):  
Parameter Identification ◽  
Fermentation Process ◽  
Continuous Fermentation ◽  
Robustness Analysis ◽  
Function Technique ◽  
Improved Genetic Algorithm ◽  
Proposed Model ◽  
Biotechnological Processes ◽  
Extracellular Substances ◽  
Identification Model

Mathematical modeling and parameter estimation are critical steps in the optimization of biotechnological processes. In the 1,3-propanediol (1,3-PD) production by glycerol fermentation process under anaerobic conditions, 3-hydroxypropionaldehyde (3-HPA) accumulation would arouse an irreversible cessation of the fermentation process. Considering 3-HPA inhibitions to cells growth and to activities of enzymes, we propose a novel mathematical model to describe glycerol continuous cultures. Some properties of the above model are discussed. On the basis of the concentrations of extracellular substances, a parameter identification model is established to determine the kinetic parameters in the presented system. Through the penalty function technique combined with an extension of the state space method, an improved genetic algorithm is then constructed to solve the parameter identification model. An illustrative numerical example shows the appropriateness of the proposed model and the validity of optimization algorithm. Since it is difficult to measure the concentrations of intracellular substances, a quantitative robustness analysis method is given to infer whether the model is plausible for the intracellular substances. Numerical results show that the proposed model is of good robustness.

Nonlinear analysis and control of a continuous fermentation process

2002 ◽  
Vol 26 (4-5) ◽  
pp. 659-670 ◽  
Author(s):  
G. Szederkényi ◽  
N.R. Kristensen ◽  
K.M. Hangos ◽  
S. Bay Jørgensen
Keyword(s):  
Nonlinear Analysis ◽  
Fermentation Process ◽  
Continuous Fermentation ◽  
And Control

Adaptive pole placement control of a continuous fermentation process

1991 ◽  
Vol 22 (12) ◽  
pp. 2625-2638 ◽  
Author(s):  
B. DAHHOU ◽  
G. ROUX ◽  
I. QUEINNEC ◽  
J. B. POURCIEL
Keyword(s):  
Fermentation Process ◽  
Continuous Fermentation ◽  
Pole Placement ◽  
Pole Placement Control

A novel model for continuous fermentation process for Worcestershire sauce production using a trickle bed bioreactor

1996 ◽  
Vol 81 (3) ◽  
pp. 233-239 ◽  
Author(s):  
Tetsuya Fukaya ◽  
Yoshiya Furuta ◽  
Yukio Ishiguro ◽  
Hiroyuki Horitsu ◽  
Kazuhiro Takamizawa
Keyword(s):  
Fermentation Process ◽  
Continuous Fermentation ◽  
Trickle Bed ◽  
Trickle Bed Bioreactor ◽  
Novel Model
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