Exam 1: Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies

2015 ◽  
Vol 13 (4) ◽  
pp. e39-e40 ◽  
Keyword(s):  
Systematic Review ◽  
Fatty Liver ◽  
Nonalcoholic Steatohepatitis ◽  
Meta Analysis ◽  
Nonalcoholic Fatty Liver ◽  
Fibrosis Progression

Sa1052 Fibrosis Progression in Nonalcoholic Fatty Liver Versus Nonalcoholic Steatohepatitis: A Systematic Review and Meta-Analysis of Paired-Biopsy Studies

2014 ◽  
Vol 146 (5) ◽  
pp. S-947-S-948 ◽  
Author(s):  
Siddharth Singh ◽  
Alina M. Allen ◽  
Zhen Wang ◽  
Larry J. Prokop ◽  
Mohammad H. Murad ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fatty Liver ◽  
Nonalcoholic Steatohepatitis ◽  
Meta Analysis ◽  
Nonalcoholic Fatty Liver ◽  
Fibrosis Progression

scholarly journals Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies

2015 ◽  
Vol 13 (4) ◽  
pp. 643-654.e9 ◽  
Author(s):  
Siddharth Singh ◽  
Alina M. Allen ◽  
Zhen Wang ◽  
Larry J. Prokop ◽  
Mohammad H. Murad ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fatty Liver ◽  
Nonalcoholic Steatohepatitis ◽  
Meta Analysis ◽  
Nonalcoholic Fatty Liver ◽  
Fibrosis Progression

A systematic review and a dose–response meta-analysis of coffee dose and nonalcoholic fatty liver disease

2019 ◽  
Vol 38 (6) ◽  
pp. 2552-2557 ◽  
Author(s):  
Yong-Ping Chen ◽  
Feng-Bin Lu ◽  
Yi-Bing Hu ◽  
Lan-Man Xu ◽  
Ming-Hua Zheng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Dose Response ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Nonalcoholic Fatty Liver

scholarly journals The Association between Periodontitis and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

2020 ◽  
Vol 29 (2) ◽  
pp. 211-217
Author(s):  
Karn Wijarnpreecha ◽  
Panadeekarn Panjawatanan ◽  
Wisit Cheungpasitporn ◽  
Frank J Lukens ◽  
Denise M Harnois ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Periodontal Pocket ◽  
Nonalcoholic Fatty Liver ◽  
Unadjusted Analysis

Background and Aims: Recent studies have suggested an association between periodontitis and nonalcoholic fatty liver disease (NAFLD) although the results were inconsistent. The current systematic review and meta- analysis was conducted with the aim to comprehensively investigate this possible association by identifying all relevant studies and combining their results together. Methods: A comprehensive literature review was conducted utilizing the MEDLINE and EMBASE databases through December 2019 to identify all studies that compared the risk of NAFLD among patients with periodontitis to individuals without periodontitis. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: A total of five studies with 27,703 participants fulfilled the eligibility criteria and were included in the meta-analysis. All five studies reported the magnitude of association between NAFLD and periodontitis that was diagnosed based on the periodontal pocket depth of > 3.5-4 mm. The pooled OR of unadjusted analysis was 1.48 (95%CI: 1.15-1.89; I 2 92%). However, when adjusted results from the primary studies were used, pooled OR decreased to 1.13 and lost its statistical significance (95%CI: 0.95–1.35; I 2 67%). Three studies reported the magnitude of association between NAFLD and periodontitis that was diagnosed based on a clinical attachment level of ≥ 3 mm. The pooled OR of unadjusted analysis was 1.13 (95%CI: 1.07-1.20; I 2 0%). However, when adjusted results from the primary studied were used, pooled OR decreased to 1.08 and lost its statistical significance (95%CI: 0.94–1.24; I 2 58%). Conclusions: The study found a significant association between periodontitis and NAFLD. However, the association lost its significance when various metabolic parameters were adjusted, suggesting that those metabolic conditions, not periodontitis itself, were predisposing factors for NAFLD.

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