Abstract
Background and Aims
Current consensus recommendations define small bowel strictures (SBS) in Crohn’s disease (CD) on imaging as luminal narrowing with unequivocal upstream bowel dilation. The aim of this study was to 1) evaluate the performance of cross-sectional imaging for SBS diagnosis in CD using luminal narrowing with upstream SB dilation and luminal narrowing with or without upstream dilation, and 2) compare the diagnostic performance of CT and MR enterography (MRE) for SBS diagnosis.
Methods
One hundred and eleven CD patients (81 with pathologically confirmed SBS, 30 controls) who underwent CT and/or MRE were assessed. Two radiologists (R1, R2) blinded to pathology findings independently assessed the presence of luminal narrowing and upstream SB dilation. Statistical analysis was performed for a) luminal narrowing with or without SB upstream dilation (“possible SBS”), b) luminal narrowing with upstream SB dilation ≥3cm (“definite SBS”).
Results
Sensitivity for detecting SBS was significantly higher using “possible SBS” (R1, 82.1%; R2, 77.9%) compared to “definite SBS” (R1, 62.1%; R2, 65.3%; p<0.0001) with equivalent specificity (R1, 96.7%; R2, 93.3%; p>0.9). Using criterion “possible SBS”, sensitivity/specificity were equivalent between CT (R1, 87.3%/93.3%; R2, 83.6%/86.7%) and MRE (R1, 75.0%/100%; R2: 70.0%/100%). Using criterion “definite SBS”, CT showed significantly higher sensitivity (78.2%) compared to MRE (40.0%) for R1 but not R2 with similar specificities (CT, 86.7%-93.3%; MRE, 100%).
Conclusion
SBS can be diagnosed using luminal narrowing alone without the need for upstream dilation. CT and MRE show similar diagnostic performance for SBS diagnosis using luminal narrowing with or without upstream dilation.
P264. Meta-analytic Bayesian model for differentiating intestinal tuberculosis from Crohn’s disease utilising clinical, endoscopic, and cross-sectional imaging findings, and the interferon-gamma releasing assay
