Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA polymerase I inhibitors for colorectal cancer treatment

Victoria Sanchez-Martin; David A. Schneider; Matilde Ortiz-Gonzalez; Ana Soriano-Lerma; Angel Linde-Rodriguez; Virginia Perez-Carrasco; Jose Gutierrez-Fernandez; Marta Cuadros; Juan C. Morales; Carlos González; Miguel Soriano; Jose A. Garcia-Salcedo

doi:10.1016/j.chembiol.2021.12.007

Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA polymerase I inhibitors for colorectal cancer treatment

Cell Chemical Biology ◽

10.1016/j.chembiol.2021.12.007 ◽

2021 ◽

Vol 28 (12) ◽

pp. 1807

Author(s):

Victoria Sanchez-Martin ◽

David A. Schneider ◽

Matilde Ortiz-Gonzalez ◽

Ana Soriano-Lerma ◽

Angel Linde-Rodriguez ◽

...

Keyword(s):

Colorectal Cancer ◽

Rna Polymerase ◽

Cancer Treatment ◽

Rna Polymerase I ◽

Polymerase I ◽

Naphthalene Diimides ◽

Colorectal Cancer Treatment

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Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA polymerase I inhibitors for colorectal cancer treatment

Cell Chemical Biology ◽

10.1016/j.chembiol.2021.05.021 ◽

2021 ◽

Author(s):

Victoria Sanchez-Martin ◽

David A. Schneider ◽

Matilde Ortiz-Gonzalez ◽

Ana Soriano-Lerma ◽

Angel Linde-Rodriguez ◽

...

Keyword(s):

Colorectal Cancer ◽

Rna Polymerase ◽

Cancer Treatment ◽

Rna Polymerase I ◽

Polymerase I ◽

Naphthalene Diimides ◽

Colorectal Cancer Treatment

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Faculty Opinions recommendation of TFIIH plays an essential role in RNA polymerase I transcription.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1006376.79958 ◽

2002 ◽

Author(s):

Lucio Comai

Keyword(s):

Rna Polymerase ◽

Essential Role ◽

Rna Polymerase I ◽

Polymerase I

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Faculty Opinions recommendation of RNA polymerase I propagates unidirectional spreading of rDNA silent chromatin.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1011190.179713 ◽

2003 ◽

Author(s):

Lucio Comai

Keyword(s):

Rna Polymerase ◽

Rna Polymerase I ◽

Silent Chromatin ◽

Polymerase I

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Faculty Opinions recommendation of In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1012188.184671 ◽

2003 ◽

Author(s):

Jonathan R Warner

Keyword(s):

Saccharomyces Cerevisiae ◽

Rna Polymerase ◽

Loading Rate ◽

Rna Polymerase I ◽

Rrna Synthesis ◽

Polymerase I ◽

Active Genes

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Faculty Opinions recommendation of RNA polymerase I remains intact without subunit exchange through multiple rounds of transcription in Saccharomyces cerevisiae.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1021818.248652 ◽

2004 ◽

Author(s):

Daniel Reines

Keyword(s):

Saccharomyces Cerevisiae ◽

Rna Polymerase ◽

Rna Polymerase I ◽

Subunit Exchange ◽

Polymerase I

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Faculty Opinions recommendation of Cdc14 inhibits transcription by RNA polymerase I during anaphase.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1157580.617770 ◽

2009 ◽

Author(s):

Andrew D Sharrocks

Keyword(s):

Rna Polymerase ◽

Rna Polymerase I ◽

Polymerase I

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Faculty Opinions recommendation of TAF1B is a TFIIB-like component of the basal transcription machinery for RNA polymerase I.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13427964.14802063 ◽

2011 ◽

Author(s):

Katsuhiko Murakami ◽

Sung-hoon Jun

Keyword(s):

Rna Polymerase ◽

Rna Polymerase I ◽

Basal Transcription ◽

Basal Transcription Machinery ◽

Transcription Machinery ◽

Polymerase I

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Faculty Opinions recommendation of RNA polymerase I structure and transcription regulation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718153960.793491178 ◽

2014 ◽

Author(s):

Sui Huang

Keyword(s):

Rna Polymerase ◽

Transcription Regulation ◽

Rna Polymerase I ◽

Polymerase I

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Faculty Opinions recommendation of Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726489647.793521907 ◽

2016 ◽

Author(s):

Ian Willis

Keyword(s):

Rna Polymerase ◽

Transcription Initiation ◽

Rna Polymerase I ◽

Polymerase I

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Faculty Opinions recommendation of RNA polymerase I activators count and adjust ribosomal RNA gene copy number.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734776122.793556076 ◽

2019 ◽

Author(s):

Angela Taddei

Keyword(s):

Rna Polymerase ◽

Ribosomal Rna ◽

Copy Number ◽

Gene Copy Number ◽

Rna Polymerase I ◽

Gene Copy ◽

Ribosomal Rna Gene ◽

Polymerase I

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