scholarly journals Characterizing the structure of styrene-maleic acid copolymer-lipid nanoparticles (SMALPs) using RAFT polymerization for membrane protein spectroscopic studies

2019 ◽  
Vol 218 ◽  
pp. 65-72 ◽  
Author(s):  
Benjamin D. Harding ◽  
Gunjan Dixit ◽  
Kevin M. Burridge ◽  
Indra D. Sahu ◽  
Carole Dabney-Smith ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Maleic Acid ◽  
Raft Polymerization ◽  
Lipid Nanoparticles ◽  
Spectroscopic Studies ◽  
Acid Copolymer ◽  
Maleic Acid Copolymer

scholarly journals Characterizing the Structure of Styrene Maleic Acid Copolymer Lipid Nanoparticles (SMALPS) Using Raft Polymerization for Membrane Protein Spectroscopic Studies

2020 ◽  
Vol 118 (3) ◽  
pp. 361a-362a
Author(s):  
Benjamin D. Harding ◽  
Gunjan Dixit ◽  
Kevin M. Burridge ◽  
Gary A. Lorigan ◽  
Indra D. Sahu ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Maleic Acid ◽  
Raft Polymerization ◽  
Lipid Nanoparticles ◽  
Spectroscopic Studies ◽  
Acid Copolymer ◽  
Maleic Acid Copolymer

scholarly journals Characterizing the Structure of Styrene-Maleic Acid Copolymer-Lipid Nanoparticles (SMALPS) using Raft Polymerization for Membrane Protein Spectroscopic Studies

2019 ◽  
Vol 116 (3) ◽  
pp. 517a
Author(s):  
Benjamin D. Harding ◽  
Gunjan Dixit ◽  
Kevin M. Burridge ◽  
Indra D. Sahu ◽  
Carole Dabney-Smith ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Maleic Acid ◽  
Raft Polymerization ◽  
Lipid Nanoparticles ◽  
Spectroscopic Studies ◽  
Acid Copolymer ◽  
Maleic Acid Copolymer

scholarly journals Tuning the size of styrene-maleic acid copolymer-lipid nanoparticles (SMALPs) using RAFT polymerization for biophysical studies

2016 ◽  
Vol 1858 (11) ◽  
pp. 2931-2939 ◽  
Author(s):  
Andrew F. Craig ◽  
Emily E. Clark ◽  
Indra D. Sahu ◽  
Rongfu Zhang ◽  
Nick D. Frantz ◽  
...  
Keyword(s):  
Maleic Acid ◽  
Raft Polymerization ◽  
Lipid Nanoparticles ◽  
Acid Copolymer ◽  
Biophysical Studies ◽  
Maleic Acid Copolymer

Functional Integrity of Membrane Protein Rhodopsin Solubilized by Styrene-Maleic Acid Copolymer

2021 ◽  
Author(s):  
Stephanie G. Pitch ◽  
Weekie Yao ◽  
Istvan Szundi ◽  
Jonathan Fay ◽  
Eefei Chen ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Maleic Acid ◽  
Functional Integrity ◽  
Acid Copolymer ◽  
Maleic Acid Copolymer

Styrene-maleic acid copolymer effects on the function of the GPCR rhodopsin in lipid nanoparticles

2021 ◽  
Author(s):  
Istvan Szundi ◽  
Stephanie G. Pitch ◽  
Eefei Chen ◽  
David L. Farrens ◽  
David S. Kliger
Keyword(s):  
Maleic Acid ◽  
Lipid Nanoparticles ◽  
Acid Copolymer ◽  
Maleic Acid Copolymer

Comparative Analysis of Maleic Acid Copolymer-Based Lipid Nanodiscs Reveals Preferential Lipid and Protein Solubilization

2020 ◽  
Author(s):  
Marta Barniol-Xicota ◽  
Steven Verhelst
Keyword(s):  
Comparative Analysis ◽  
Membrane Proteins ◽  
Membrane Protein ◽  
Protein Content ◽  
Lipid Bilayer ◽  
Maleic Acid ◽  
Chemical Properties ◽  
Acid Copolymer ◽  
Lipid Nanodiscs ◽  
Maleic Acid Copolymer

Membrane proteins are key in a large number of physiological and pathological processes. Their study often involves a prior detergent solubilization step, which strips away the membrane and can jeopardize membrane protein integrity. A recent alternative to detergents encompasses maleic acid based copolymers (xMAs), which disrupt the lipid bilayer and form lipid protein nanodiscs (xMALPs) soluble in aqueous buffer. Although xMALPs are often referred to as native nanodiscs, little is known about the resemblance of their lipid and protein content to the native bilayer. Here we have analyzed prokaryotic and eukaryotic xMALPs using lipidomics and in-gel analysis. Our results show that the xMALPs content varies with the chemical properties of the used xMA and that some of these nanodiscs are less native than initially thought.<br>

scholarly journals Structural characterization of styrene-maleic acid copolymer-lipid nanoparticles (SMALPs) using EPR spectroscopy

2019 ◽  
Vol 220 ◽  
pp. 6-13 ◽  
Author(s):  
Avnika P. Bali ◽  
Indra D. Sahu ◽  
Andrew F. Craig ◽  
Emily E. Clark ◽  
Kevin M. Burridge ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Epr Spectroscopy ◽  
Maleic Acid ◽  
Lipid Nanoparticles ◽  
Acid Copolymer ◽  
Maleic Acid Copolymer

scholarly journals Comparative Analysis of Maleic Acid Copolymer-Based Lipid Nanodiscs Reveals Preferential Lipid and Protein Solubilization

2020 ◽  
Author(s):  
Marta Barniol-Xicota ◽  
Steven Verhelst
Keyword(s):  
Comparative Analysis ◽  
Membrane Proteins ◽  
Membrane Protein ◽  
Protein Content ◽  
Lipid Bilayer ◽  
Maleic Acid ◽  
Chemical Properties ◽  
Acid Copolymer ◽  
Lipid Nanodiscs ◽  
Maleic Acid Copolymer

Membrane proteins are key in a large number of physiological and pathological processes. Their study often involves a prior detergent solubilization step, which strips away the membrane and can jeopardize membrane protein integrity. A recent alternative to detergents encompasses maleic acid based copolymers (xMAs), which disrupt the lipid bilayer and form lipid protein nanodiscs (xMALPs) soluble in aqueous buffer. Although xMALPs are often referred to as native nanodiscs, little is known about the resemblance of their lipid and protein content to the native bilayer. Here we have analyzed prokaryotic and eukaryotic xMALPs using lipidomics and in-gel analysis. Our results show that the xMALPs content varies with the chemical properties of the used xMA and that some of these nanodiscs are less native than initially thought.<br>

scholarly journals Development of discoidal phospholipid bilayer nanoparticles with styrene maleic acid copolymer for diagnosis and therapy of intractable cancers

2021 ◽  
Vol 96-97 ◽  
pp. S83
Author(s):  
Masayuki Munekane ◽  
Wakana Yamaguchi ◽  
Kohei Sano ◽  
Toshihide Yamasaki ◽  
Masafumi Tanaka ◽  
...  
Keyword(s):  
Maleic Acid ◽  
Phospholipid Bilayer ◽  
Diagnosis And Therapy ◽  
Acid Copolymer ◽  
Maleic Acid Copolymer
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