The first carbon-carbon bond formation mechanism in methanol-to-hydrocarbons process over chabazite zeolite

Carbon-carbon bond formation by transition metal-catalyzed C–H activation has become an important strategy to fabricate new bonds in a rapid fashion. Despite the pharmacological importance of ortho-arylbenzylamines, however, effective ortho-C–C bond formation from C–H bond activation of free primary and secondary benzylamines using PdII remains an outstanding challenge. Presented herein is a new strategy for constructing ortho-arylated primary and secondary benzylamines mediated by carbon dioxide (CO2). The use of CO2 is critical to allowing this transformation to proceed under milder conditions than previously reported, and that are necessary to furnish free amine products that can be directly used or elaborated without the need for deprotection. In cases where diarylation is possible, a chelate effect is demonstrated to facilitate selective monoarylation.

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Faculty Opinions recommendation of Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1008763.293742 ◽

2005 ◽

Author(s):

Bruce Eaton

Keyword(s):

Bond Formation ◽

Diels Alder ◽

Structural Basis ◽

Carbon Bond ◽

Carbon Carbon Bond

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Palladium Deposited on Naturally Occurring Supports as a Powerful Catalyst for Carbon-Carbon Bond Formation Reactions

Current Organic Chemistry ◽

10.2174/1385272819666150423202719 ◽

2015 ◽

Vol 20 (4) ◽

pp. 327-348 ◽

Cited By ~ 25

Author(s):

Arash Ghaderi ◽

Mohammad Gholinejad ◽

Habib Firouzabadi

Keyword(s):

Bond Formation ◽

Carbon Bond ◽

Naturally Occurring ◽

Carbon Carbon Bond ◽

Bond Formation Reactions

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Modern Organic Synthesis in the Laboratory

10.1093/oso/9780195187984.001.0001 ◽

2008 ◽

Cited By ~ 1

Author(s):

Jie Jack Li ◽

Chris Limberakis ◽

Derek A. Pflum

Keyword(s):

Organic Chemistry ◽

Graduate Students ◽

Organic Synthesis ◽

Functional Group ◽

Bond Formation ◽

Reaction Conditions ◽

Carbon Bond ◽

Oxidation Reduction ◽

Carbon Carbon Bond ◽

Daunting Task

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to decide what reaction conditions to experiment with first in order to have the best chance of success. This collection intends to serve as an "older and wiser lab-mate" one could have by compiling many of the most commonly used experimental procedures in organic synthesis. With chapters that cover such topics as functional group manipulations, oxidation, reduction, and carbon-carbon bond formation, Modern Organic Synthesis in the Laboratory will be useful for both graduate students and professors in organic chemistry and medicinal chemists in the pharmaceutical and agrochemical industries.

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