MEPOLIZUMAB REDUCES EXACERBATIONS IN PATIENTS WITH SEVERE EOSINOPHILIC ASTHMA IRRESPECTIVE OF BASELINE MAINTENANCE OCS USE: META-ANALYSIS FROM TWO PH3 TRIALS

CHEST Journal ◽  
2019 ◽  
Vol 156 (4) ◽  
pp. A1745-A1746
Author(s):  
Steven Smith ◽  
Njira Lugogo ◽  
Ian Pavord ◽  
Elisabeth Bel ◽  
Jean-Pierre Llanos-Ackert ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Eosinophilic Asthma ◽  
Severe Eosinophilic Asthma

Reslizumab and mepolizumab for moderate-to-severe poorly controlled asthma: an indirect comparison meta-analysis

Immunotherapy ◽  
2019 ◽  
Vol 11 (17) ◽  
pp. 1491-1505 ◽  
Author(s):  
Kevin Yan ◽  
Chakrapani Balijepalli ◽  
Rohini Sharma ◽  
Stephane Barakat ◽  
Shawn X Sun ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Indirect Comparison ◽  
Base Case ◽  
Efficacy And Safety ◽  
Eosinophilic Asthma ◽  
Severe Eosinophilic Asthma ◽  
Global Initiative For Asthma ◽  
Credible Intervals ◽  
Global Initiative ◽  
Eosinophil Counts

Aim: A systematic literature review and network meta-analysis assessed the efficacy and safety of reslizumab 3.0 mg/kg and mepolizumab 100 mg. Materials & methods: Eligible studies evaluated reslizumab and mepolizumab in patients with inadequately-controlled severe eosinophilic asthma. Using a Bayesian network meta-analysis, 95% credible intervals and posterior probabilities were reported. Results: Of 19 indirect efficacy comparisons performed in base-case (Global Initiative for Asthma 4/5 patients with ≥2 exacerbations in the previous year) and overall populations, significant differences favoring reslizumab were observed for severe exacerbations, FEV1 at 4 weeks and eosinophil counts at 4, 16 and 24 weeks, with no other significant differences including risk of adverse events. Conclusion: Indirect comparison of reslizumab and mepolizumab largely showed no significant differences in efficacy or safety.

scholarly journals Meta-analysis of asthma-related hospitalization in mepolizumab studies of severe eosinophilic asthma

2017 ◽  
Vol 139 (4) ◽  
pp. 1167-1175.e2 ◽  
Author(s):  
Steven W. Yancey ◽  
Hector G. Ortega ◽  
Oliver N. Keene ◽  
Bhabita Mayer ◽  
Necdet B. Gunsoy ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Eosinophilic Asthma ◽  
Severe Eosinophilic Asthma

scholarly journals Efficacy Of 100 Mg SC Mepolizumab For Severe Eosinophilic Asthma (SEA) Across Blood Eosinophil Counts: Meta-Analysis

2019 ◽  
Vol 143 (2) ◽  
pp. AB101 ◽  
Author(s):  
Steven W. Yancey ◽  
Frank Albers ◽  
Daniel J. Bratton ◽  
Eric S. Bradford ◽  
Namhee Kwon ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Blood Eosinophil ◽  
Eosinophilic Asthma ◽  
Severe Eosinophilic Asthma ◽  
Eosinophil Counts

scholarly journals Seasonal efficacy of mepolizumab in patients with severe eosinophilic asthma – meta-analysis from two phase 3 trials

2020 ◽  
Vol 145 (2) ◽  
pp. AB22
Author(s):  
Camille Taillé ◽  
Elliot Israel ◽  
Jason Lee ◽  
Alina Gruber ◽  
Steven Smith ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Phase 3 ◽  
Two Phase ◽  
Eosinophilic Asthma ◽  
Severe Eosinophilic Asthma

К ВОПРОСУ ВЫБОРА ИММУНОБИОЛОГИЧЕСКОЙ ТЕРАПИИ БРОНХИАЛЬНОЙ АСТМЫ

2019 ◽  
Author(s):  
N.I. Ilina
Keyword(s):  
Meta Analysis ◽  
Cochrane Review ◽  
Eosinophilic Asthma ◽  
Indirect Treatment Comparison ◽  
Severe Eosinophilic Asthma ◽  
Treatment Comparison ◽  
Indirect Treatment

В статье представлены результаты непрямого сравнения исследований эффективности анти-ИЛ-5-терапии при тяжелой эозинофильной астме на основании мета-анализа плацебо-контролируемых исследований и кохрановского обзора.The results of indirect treatment comparison of the efficacy of anti-Il-5 pathway therapies in severe eosinophilic asthma on the basis of network meta-analysis and Cochrane review are presented in the article.

scholarly journals BASELINE PERCENT PREDICTED FEV1 DOES NOT PREDICT A RESPONSE TO MEPOLIZUMAB IN PATIENTS WITH SEVERE EOSINOPHILIC ASTHMA: META-ANALYSIS FROM TWO PHASE 3 TRIALS

CHEST Journal ◽  
2019 ◽  
Vol 156 (4) ◽  
pp. A459-A460 ◽  
Author(s):  
Jared Silver ◽  
Andrew Menzies-Gow ◽  
Steven Smith ◽  
Stephen Mallett ◽  
Eric Bradford ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Phase 3 ◽  
Two Phase ◽  
Eosinophilic Asthma ◽  
Severe Eosinophilic Asthma
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