Ion exchange chromatography of monoclonal antibodies: Effect of resin ligand density on dynamic binding capacity

Ann Marie Hardin; Chithkala Harinarayan; Gunnar Malmquist; Andreas Axén; Robert van Reis

doi:10.1016/j.chroma.2008.08.047

Ion exchange chromatography of monoclonal antibodies: Effect of resin ligand density on dynamic binding capacity

Journal of Chromatography A ◽

10.1016/j.chroma.2008.08.047 ◽

2009 ◽

Vol 1216 (20) ◽

pp. 4366-4371 ◽

Cited By ~ 53

Author(s):

Ann Marie Hardin ◽

Chithkala Harinarayan ◽

Gunnar Malmquist ◽

Andreas Axén ◽

Robert van Reis

Keyword(s):

Monoclonal Antibodies ◽

Ion Exchange ◽

Binding Capacity ◽

Ion Exchange Chromatography ◽

Exchange Chromatography ◽

Dynamic Binding ◽

Ligand Density ◽

Dynamic Binding Capacity

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Development of ion exchange chromatography methods for monoclonal antibodies

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/s0731-7085(00)00236-3 ◽

2000 ◽

Vol 22 (3) ◽

pp. 605-611 ◽

Cited By ~ 13

Author(s):

Lin Bai ◽

Sudhir Burman ◽

Linden Gledhill

Keyword(s):

Monoclonal Antibodies ◽

Ion Exchange ◽

Ion Exchange Chromatography ◽

Exchange Chromatography

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One-step purification of mouse monoclonal antibodies by mass ion exchange chromatography on Zetaprep

Journal of Immunological Methods ◽

10.1016/0022-1759(87)90132-3 ◽

1987 ◽

Vol 99 (2) ◽

pp. 229-233 ◽

Cited By ~ 13

Author(s):

F.D. Menozzi ◽

P. Vanderpoorten ◽

C. Dejaiffe ◽

A.O.A. Miller

Keyword(s):

Monoclonal Antibodies ◽

Ion Exchange ◽

Ion Exchange Chromatography ◽

Exchange Chromatography ◽

One Step

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Effects of stationary phase ligand density on high-performance ion-exchange chromatography of proteins

Journal of Chromatography A ◽

10.1016/0021-9673(92)85108-6 ◽

1992 ◽

Vol 598 (1) ◽

pp. 7-13 ◽

Cited By ~ 48

Author(s):

Danlin Wu ◽

Rodney R. Walters

Keyword(s):

Ion Exchange ◽

Stationary Phase ◽

High Performance ◽

Ion Exchange Chromatography ◽

Exchange Chromatography ◽

Ligand Density

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Electrostatic model for protein adsorption in ion-exchange chromatography and application to monoclonal antibodies, lysozyme and chymotrypsinogen A

Journal of Chromatography A ◽

10.1016/j.chroma.2010.06.064 ◽

2010 ◽

Vol 1217 (35) ◽

pp. 5610-5621 ◽

Cited By ~ 27

Author(s):

Bertrand Guélat ◽

Guido Ströhlein ◽

Marco Lattuada ◽

Massimo Morbidelli

Keyword(s):

Monoclonal Antibodies ◽

Ion Exchange ◽

Protein Adsorption ◽

Ion Exchange Chromatography ◽

Exchange Chromatography ◽

Electrostatic Model

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Temperature influence on the dynamic binding capacity of a monolithic ion-exchange column

Journal of Chromatography A ◽

10.1016/s0021-9673(02)01811-3 ◽

2003 ◽

Vol 987 (1-2) ◽

pp. 159-168 ◽

Cited By ~ 19

Author(s):

Igor Mihelič ◽

Aleš Podgornik ◽

Tine Koloini

Keyword(s):

Ion Exchange ◽

Binding Capacity ◽

Temperature Influence ◽

Dynamic Binding ◽

Exchange Column ◽

Dynamic Binding Capacity ◽

Ion Exchange Column

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Optimization of Dynamic Binding Capacity of Anion Exchange Chromatography Media for Recombinant Erythropoietin Purification

Iranian Journal of Biotechnology ◽

10.5812/ijb.17352 ◽

2014 ◽

Vol 12 (2) ◽

Cited By ~ 2

Author(s):

Mina Sepahi ◽

Hooman Kaghazian ◽

Mina Payravi Sereshkeh ◽

Tahereh Sadeghcheh ◽

Shahin Hadadian ◽

...

Keyword(s):

Anion Exchange ◽

Binding Capacity ◽

Anion Exchange Chromatography ◽

Exchange Chromatography ◽

Recombinant Erythropoietin ◽

Dynamic Binding ◽

Dynamic Binding Capacity

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Orientation of monoclonal antibodies in ion-exchange chromatography: A predictive quantitative structure–activity relationship modeling approach

Journal of Chromatography A ◽

10.1016/j.chroma.2017.06.047 ◽

2017 ◽

Vol 1510 ◽

pp. 33-39 ◽

Cited By ~ 6

Author(s):

Jörg Kittelmann ◽

Katharina M.H. Lang ◽

Marcel Ottens ◽

Jürgen Hubbuch

Keyword(s):

Monoclonal Antibodies ◽

Ion Exchange ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Ion Exchange Chromatography ◽

Exchange Chromatography ◽

Activity Relationship ◽

Quantitative Structure ◽

Modeling Approach ◽

Structure Activity

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Charge heterogeneity profiling of monoclonal antibodies using low ionic strength ion-exchange chromatography and well-controlled pH gradients on monolithic columns

Journal of Chromatography A ◽

10.1016/j.chroma.2013.08.061 ◽

2013 ◽

Vol 1317 ◽

pp. 148-154 ◽

Cited By ~ 38

Author(s):

Mohammad Talebi ◽

Anna Nordborg ◽

Andras Gaspar ◽

Nathan A. Lacher ◽

Qian Wang ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Ionic Strength ◽

Ion Exchange ◽

Ion Exchange Chromatography ◽

Exchange Chromatography ◽

Monolithic Columns ◽

Charge Heterogeneity ◽

Ph Gradients ◽

Low Ionic Strength

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Modeling electrostatic exclusion effects during ion exchange chromatography of monoclonal antibodies

Biotechnology and Bioengineering ◽

10.1002/bit.22145 ◽

2009 ◽

Vol 102 (4) ◽

pp. 1131-1140 ◽

Cited By ~ 23

Author(s):

Andrew L. Zydney ◽

Chithkala Harinarayan ◽

Robert van Reis

Keyword(s):

Monoclonal Antibodies ◽

Ion Exchange ◽

Ion Exchange Chromatography ◽

Exchange Chromatography

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Capillary ion-exchange chromatography with nanogram sensitivity for the analysis of monoclonal antibodies

Journal of Chromatography A ◽

10.1016/j.chroma.2015.11.002 ◽

2015 ◽

Vol 1424 ◽

pp. 77-85 ◽

Cited By ~ 8

Author(s):

Jennifer C. Rea ◽

Benny S. Freistadt ◽

Daniel McDonald ◽

Dell Farnan ◽

Yajun Jennifer Wang

Keyword(s):

Monoclonal Antibodies ◽

Ion Exchange ◽

Ion Exchange Chromatography ◽

Exchange Chromatography

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