Synthesis of a chiral ionic liquid, cholinium-clindamycin phosphate, as sole chiral selector in capillary electrophoresis

2020 ◽  
Vol 1615 ◽  
pp. 460721 ◽  
Author(s):  
Hui Xu ◽  
Yingxiang Du ◽  
Zijie Feng ◽  
Xiaodong Sun ◽  
Jie Liu
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
Chiral Selector ◽  
Clindamycin Phosphate ◽  
Chiral Ionic Liquid

L-Histidinium Chiral Ionic Liquid Functionalized β-Cyclodextrin as Chiral Selector in Capillary Electrophoresis

2021 ◽  
Author(s):  
Xiaofei Ma ◽  
Jingtang Li ◽  
Xiaoqi Li ◽  
Zijie Feng ◽  
Xuan Yang ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
Ionic Liquids ◽  
Molecular Modeling ◽  
Chiral Separation ◽  
Chiral Selector ◽  
Chiral Discrimination ◽  
Chiral Ionic Liquid ◽  
First Time ◽  
Good Agreement

Abstract Nowadays, ionic liquids (ILs) functionalized cyclodextrins (CDs) have drawn increasing attention in chiral separation. Herein, a novel β-CD derivative functionalized by L-histidinium IL, mono-6-deoxy-6-L-histidinium-β-cyclodextrin chloride (L-HMCDCl), was synthesized for the first time and utilized for enantioseparation of nefopam and chlorphenamine in capillary electrophoresis. The L-HMCDCl exhibited superior enantioselectivity compared with native β-CD. The effect of some key parameters such as chiral selector concentration, buffer pH and applied voltage on the enantioseparation was investigated in detail. In the interest of the chiral discrimination mechanism and the enhanced enantioselectivity of L-HMCDCl, molecular modeling with AutoDock was employed to study the interaction, which was in good agreement with experimental results.

Evaluation of an ionic liquid chiral selector based on clindamycin phosphate in capillary electrophoresis

2019 ◽  
Vol 411 (22) ◽  
pp. 5855-5866 ◽  
Author(s):  
Xiaofei Ma ◽  
Yingxiang Du ◽  
Xinqi Zhu ◽  
Zijie Feng ◽  
Cheng Chen ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
Chiral Selector ◽  
Clindamycin Phosphate

Chiral separation of phenylalanine and tryptophan by capillary electrophoresis using a mixture ofβ-CD and chiral ionic liquid ([TBA] [l-ASP]) as selectors

2013 ◽  
Vol 28 (5) ◽  
pp. 610-614 ◽  
Author(s):  
Wu Yujiao ◽  
Wang Guoyan ◽  
Zhao Wenyan ◽  
Zhang Hongfen ◽  
Jing Huanwang ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
Chiral Separation ◽  
Chiral Ionic Liquid
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