Establishment and Evaluation of the Novel Tetramethylammonium-L-Hydroxyproline Chiral Ionic Liquid Synergistic System Based on Clindamycin Phosphate for Enantioseparation by Capillary Electrophoresis

Chirality ◽  
2015 ◽  
Vol 27 (9) ◽  
pp. 598-604 ◽  
Author(s):  
Guangfu Xu ◽  
Yingxiang Du ◽  
Fan Du ◽  
Jiaquan Chen ◽  
Tao Yu ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
The Novel ◽  
Clindamycin Phosphate ◽  
Chiral Ionic Liquid

Chiral separation of phenylalanine and tryptophan by capillary electrophoresis using a mixture ofβ-CD and chiral ionic liquid ([TBA] [l-ASP]) as selectors

2013 ◽  
Vol 28 (5) ◽  
pp. 610-614 ◽  
Author(s):  
Wu Yujiao ◽  
Wang Guoyan ◽  
Zhao Wenyan ◽  
Zhang Hongfen ◽  
Jing Huanwang ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
Chiral Separation ◽  
Chiral Ionic Liquid

Enantioseparation of amino alcohol drugs by nonaqueous capillary electrophoresis with a maltobionic acid-based ionic liquid as the chiral selector

The Analyst ◽  
2019 ◽  
Vol 144 (24) ◽  
pp. 7468-7477 ◽  
Author(s):  
Xiaofei Ma ◽  
Zigui Kan ◽  
Yingxiang Du ◽  
Jiangxia Yang ◽  
Zijie Feng ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
Amino Alcohol ◽  
Chiral Selector ◽  
The Novel ◽  
Nonaqueous Capillary Electrophoresis ◽  
Capillary Electrophoretic

This study deals with the nonaqueous capillary electrophoretic enantioseparation of twenty-two amino alcohol drugs with a maltobionic acid (MA)-based ionic liquid (tetramethylammonium maltobionic acid, TMA-MA) as the novel chiral selector.

L-Histidinium Chiral Ionic Liquid Functionalized β-Cyclodextrin as Chiral Selector in Capillary Electrophoresis

2021 ◽  
Author(s):  
Xiaofei Ma ◽  
Jingtang Li ◽  
Xiaoqi Li ◽  
Zijie Feng ◽  
Xuan Yang ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
Ionic Liquids ◽  
Molecular Modeling ◽  
Chiral Separation ◽  
Chiral Selector ◽  
Chiral Discrimination ◽  
Chiral Ionic Liquid ◽  
First Time ◽  
Good Agreement

Abstract Nowadays, ionic liquids (ILs) functionalized cyclodextrins (CDs) have drawn increasing attention in chiral separation. Herein, a novel β-CD derivative functionalized by L-histidinium IL, mono-6-deoxy-6-L-histidinium-β-cyclodextrin chloride (L-HMCDCl), was synthesized for the first time and utilized for enantioseparation of nefopam and chlorphenamine in capillary electrophoresis. The L-HMCDCl exhibited superior enantioselectivity compared with native β-CD. The effect of some key parameters such as chiral selector concentration, buffer pH and applied voltage on the enantioseparation was investigated in detail. In the interest of the chiral discrimination mechanism and the enhanced enantioselectivity of L-HMCDCl, molecular modeling with AutoDock was employed to study the interaction, which was in good agreement with experimental results.

Evaluation of an ionic liquid chiral selector based on clindamycin phosphate in capillary electrophoresis

2019 ◽  
Vol 411 (22) ◽  
pp. 5855-5866 ◽  
Author(s):  
Xiaofei Ma ◽  
Yingxiang Du ◽  
Xinqi Zhu ◽  
Zijie Feng ◽  
Cheng Chen ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
Chiral Selector ◽  
Clindamycin Phosphate
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