HLA-DR3/4 Heterozygosity is a Risk Factor for Autoantibody Conversion and Type 1 Diabetes Recurrence After Simultaneous Pancreas-Kidney Transplantation

2007 ◽  
Vol 123 ◽  
pp. S22
Author(s):  
Stavros Diamantopoulos ◽  
Gloria Allende ◽  
George W. Burke ◽  
Gaetano Ciancio ◽  
Alberto Pugliese
Keyword(s):  
Type 1 Diabetes ◽  
Risk Factor ◽  
Kidney Transplantation ◽  
Diabetes Recurrence ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Hla Dr3 ◽  
Simultaneous Pancreas Kidney Transplantation

Type 1 Diabetes Recurrence After Simultaneous Pancreas-Kidney Transplantation

2018 ◽  
Vol 5 (4) ◽  
pp. 295-303
Author(s):  
George W. Burke ◽  
Gaetano Ciancio ◽  
Mahmoud Morsi ◽  
Jose Figueiro ◽  
Linda Chen ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Kidney Transplantation ◽  
Diabetes Recurrence ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation

scholarly journals Mesangial sclerosis in a patient with type 1 diabetes following simultaneous pancreas-kidney transplantation despite maintenance of normoglycemia: a case report

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Boonphiphop Boonpheng ◽  
Jonathan E. Zuckerman ◽  
Gerald S. Lipshutz ◽  
Gabriel M. Danovitch ◽  
Angela Phelps ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Nephropathy ◽  
Kidney Transplantation ◽  
Serum Lipase ◽  
Oral Antihyperglycemic Agents ◽  
Allograft Function ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation

Abstract Background Simultaneous pancreas-kidney transplantation is considered a curative treatment for type 1 diabetes complicated by end-stage kidney disease. We report herein a case of mesangial sclerosis in a patient who underwent successful kidney-pancreas transplantation despite well-controlled glucose and excellent pancreatic allograft function. Case presentation A 76-year-old type 1 diabetic man who underwent a simultaneous pancreas-kidney transplantation 19 years prior presented with persistent nephrotic range proteinuria although creatinine was at his baseline (normal) level. Hemoglobin A1c and fasting glucose were well controlled without the use of insulin or oral antihyperglycemic agents. Serum lipase and amylase were within the reference range and there was no evidence of donor-specific antibodies. Kidney allograft biopsy was performed to evaluate proteinuria and showed diffuse capillary loop thickening and diffuse moderate to severe mesangial sclerosis resembling diabetic nephropathy. Conclusions This case demonstrates a case of mesangial sclerosis resembling diabetic nephropathy in a patient with good glucose control after simultaneous pancreas-kidney transplantation with excellent pancreatic allograft function.

scholarly journals 5 Years Follow-up of Diabetic Polyneuropathy with Type 1 Diabetes after Simultaneous Pancreas-kidney Transplantation

2017 ◽  
Vol 106 (8) ◽  
pp. 1640-1645
Author(s):  
Seiya Inoue ◽  
Yuko Okada ◽  
Hiroshi Miura ◽  
Tomoaki Nakamura ◽  
Hidenori Fukuoka ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Kidney Transplantation ◽  
Diabetic Polyneuropathy ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation

scholarly journals Simultaneous pancreas‐kidney transplantation in type 1 diabetes mellitus. Clinical options

2020 ◽  
Vol 23 (3) ◽  
pp. 275-282
Author(s):  
A. S. Severina ◽  
I. I. Larina ◽  
A. S Shutovа ◽  
M. S. Shamkhalova ◽  
I. V. Dmitriev ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Kidney Transplantation ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Complications ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Stage Renal Disease ◽  
Simultaneous Pancreas Kidney Transplantation

Simultaneous pancreas-kidney transplantation (SPKT) is the most promising treatment option for patients with type 1 diabetes mellitus (T1DM) and end-stage renal disease (ESRD) due to diabetic nephropathy (DN). Successful SPKT eliminates uremic intoxication and hyperglycemia the leading trigger of vascular diabetic complications. Therefore, euglycemia is an important metabolic change in patients after surgery and remains only one of the factors for the saved renal allograft functioning. In the case of resuming renal replacement therapy by dialysis after SPKT, the management and monitoring of the pancreatic graft remains open. Special attention to the pancreatic grafts function is due to both the potential risk of surgical complications, and some probability of T1DM relapse with the need to resume insulin therapy. In patients with saved function of both transplants, the assessment of the dynamics of diabetic complications in general becomes more important. The results of few studies in this regard remain contradictory. Thus, clinical options can be unpredictably diverse and require not only search for the root cause, but also optimization of rehabilitation tactics, even if the expected results are achieved.

Simultaneous pancreas-kidney transplantation in type 1 diabetes

2009 ◽  
Vol 23 ◽  
pp. 115-120 ◽  
Author(s):  
C. Morath ◽  
B. Schmied ◽  
A. Mehrabi ◽  
J. Weitz ◽  
J. Schmidt ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Kidney Transplantation ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation
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