The paraoxonase L55M and Q192R gene polymorphisms and myocardial infarction in a Tunisian population

Abstract Background Vitamin D deficiency is associated with cardiovascular diseases, including coronary artery diseases (CAD). As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Therefore, the objective of this study was to analyze three well-studied VDR gene polymorphisms—Fok1 (rs2228570), BsmI (rs1544410) and Taq1 (rs731236)—in a cohort of CAD patients after acute myocardial infarction. Methods In the presented cross-sectional study, 155 participants with CAD after acute myocardial infarction and 104 participants in a control group without CAD were enrolled. The participants in both groups were Caucasians of European origin. The genotyping of VDR polymorphisms rs2228570, rs1544410 and rs731236 was assessed by RT-PCR. Results The results show an association between the T/T genotype of the BsmI (rs1544410) and the G/G genotype of the Taq1 (rs731236) VDR polymorphism and CAD patients after acute myocardial infarction. There was no association between the Fok1 (rs2228570) VDR polymorphism and CAD patients after acute myocardial infarction. Conclusion The presented results suggest a potential association of the BsmI (rs1544410) and Taq1 (rs731236) VDR polymorphisms with CAD patients after myocardial infarction.

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Lipoprotein Lipase Gene Polymorphisms Are Associated with Myocardial Infarction Risk: A Meta-Analysis

Genetic Testing and Molecular Biomarkers ◽

10.1089/gtmb.2021.0042 ◽

2021 ◽

Vol 25 (6) ◽

pp. 434-444

Author(s):

Kunhui He ◽

Zhengping Zhu ◽

Yongheng Chen

Keyword(s):

Myocardial Infarction ◽

Lipoprotein Lipase ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Lipase Gene ◽

Lipoprotein Lipase Gene

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Hemostatic gene polymorphisms in young Sardinian with non-fatal acute myocardial infarction

Frontiers in Bioscience ◽

10.2741/e114 ◽

2010 ◽

Vol E2 (2) ◽

pp. 559-565 ◽

Cited By ~ 1

Author(s):

Ciriaco Carru

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Gene Polymorphisms

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635 RENIN-ANGIOTENSIN SYSTEM AND ACUTE MYOCARDIAL INFARCTION IN TUNISIAN POPULATION

Atherosclerosis Supplements ◽

10.1016/s1567-5688(11)70636-5 ◽

2011 ◽

Vol 12 (1) ◽

pp. 134

Author(s):

S. Mehri ◽

M. Hammami

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Renin Angiotensin System ◽

Tunisian Population ◽

Angiotensin System ◽

Renin Angiotensin

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Studies of Gene Polymorphisms and Myocardial Infarction. An Endangered Species?

Revista Española de Cardiología (English Edition) ◽

10.1016/s1885-5857(09)71660-3 ◽

2009 ◽

Vol 62 (4) ◽

pp. 347-349

Author(s):

Juan Carlos Kaski

Keyword(s):

Myocardial Infarction ◽

Endangered Species ◽

Gene Polymorphisms

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Association Between the G20210A Polymorphism of Prothrombin Gene and Myocardial Infarction in Tunisian Population

Biochemical Genetics ◽

10.1007/s10528-016-9744-y ◽

2016 ◽

Vol 54 (5) ◽

pp. 653-664 ◽

Cited By ~ 2

Author(s):

Amani Kallel ◽

Mohamed Hedi Sbaï ◽

Yousra Sédiri ◽

Moncef Feki ◽

Mohamed Sami Mourali ◽

...

Keyword(s):

Myocardial Infarction ◽

Tunisian Population ◽

Prothrombin Gene ◽

G20210a Polymorphism

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P829The impact of APOC3 and APOE gene polymorphisms on response to statin therapy in acute myocardial infarction

European Heart Journal ◽

10.1093/eurheartj/ehz747.0428 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

M Teterina ◽

A Geraskin ◽

P Potapov ◽

L Babaeva ◽

A Pisaryuk ◽

...

Keyword(s):

Myocardial Infarction ◽

Statin Therapy ◽

Gene Polymorphisms ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipid Lowering ◽

Lipid Lowering Therapy ◽

Genetic Studies ◽

Apoc3 Gene ◽

Pronounced Reduction

Abstract Background and aim Many genetic studies have been reported about the association between APOE, APOC3 gene polymorphisms and response to statin therapy in myocardial infarction, but results remain controversial. The aim of this study was to investigate the association between SNP rs7412 (APOE), rs2854117 (APOC3), rs2854116 (APOC3) and lipid-lowering effect of atorvastatin and rosuvastatin in patients with myocardial infarction. Methods Polymorphism of genes APOE (rs7412), APOC3 (rs2854117 and rs2854116) was determened. Lipid profile was determined on admission and after 1 year of treatment. Results 78 patients with myocardial infarction treated with maximal tolerated dose of atorvastatin or rosuvastatin were included. More pronounced reduction of lipid levels was associated with of T allele of rs7412 (APOE), p<0,05. ANOVA demonstrated greater low-density lipoprotein and total cholesterol decrease in patients with combination of genes CT/TT (rs7412, APOE) and CC (rs2854117, APOC3) genotypes, CT/TT (rs7412, APOE) and CT (rs2854116, APOC3) genotypes. Conclusion The genetic variants of APOC3 and APOE are useful markers and can be use to predict response to lipid-lowering therapy with statin in myocardial infarction.

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