Adenosine deaminase activity in cerebrospinal fluid and serum for the diagnosis of tuberculous meningitis

2013 ◽  
Vol 115 (9) ◽  
pp. 1831-1836 ◽  
Author(s):  
Bang-Hoon Cho ◽  
Byeong C. Kim ◽  
Geum-Jin Yoon ◽  
Seong-Min Choi ◽  
Jane Chang ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Adenosine Deaminase ◽  
Tuberculous Meningitis ◽  
Adenosine Deaminase Activity

scholarly journals Role of cerebrospinal fluid adenosine deaminase activity in the diagnosis of tuberculous meningitis in children

2017 ◽  
Vol 4 (2) ◽  
pp. 411
Author(s):  
T. Hima Bindu ◽  
R. Maheshwara Reddy
Keyword(s):  
Cerebrospinal Fluid ◽  
Adenosine Deaminase ◽  
Tuberculous Meningitis ◽  
Mean Value ◽  
Successful Outcome ◽  
Correct Treatment ◽  
Cross Sectional ◽  
Adenosine Deaminase Activity ◽  
The Mean ◽  
Meningitis In Children

Background: Early and correct treatment is essential for successful outcome in patients of tuberculous men-ingitis. Adenosine deaminase activity in the cerebrospinal fluid has been found to be a simple and useful investigation in the diagnosis of tuberculous meningitis in children.Methods: It is a cross sectional observational hospital based study conducted at the Department of Paediatrics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad, India. Children aged 2 months to 12 years were included in the study during April 2016 to October 2016.Results: The mean value of adenosine deaminase activity in the cerebrospinal fluid of tuberculous meningitis cases was 13.3±14.49. The mean cerebrospinal fluid adenosine deaminase levels in tuberculous meningitis patients was significantly higher than non-tuberculous meningitis patients with P <0.01.Conclusions: The mean cerebrospinal fluid adenosine deaminase level was significantly raised in tuberculous meningitis patients.

Determination of cerebrospinal fluid adenosine deaminase activity cut-off for the diagnosis of tuberculous meningitis in Hong Kong

2020 ◽  
Vol 73 (12) ◽  
pp. 800-802
Author(s):  
Toby Chun Hei Chan ◽  
Sammy Pak Lam Chen ◽  
Chloe Miu Mak ◽  
Chor Kwan Ching ◽  
Kristine Shik Luk ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Hong Kong ◽  
Adenosine Deaminase ◽  
Likelihood Ratio ◽  
Tuberculous Meningitis ◽  
Positive Likelihood Ratio ◽  
Negative Likelihood Ratio ◽  
Central Nervous System Lymphoma ◽  
Timely Initiation ◽  
Adenosine Deaminase Activity

AimsTuberculous meningitis (TBM) is a severe infection which may lead to serious complication and mortality. Prompt diagnosis and treatment are essential. There is a need for a simple and fast laboratory test to differentiate TBM from other causes.MethodsRetrospective review was conducted for cerebrospinal fluid adenosine deaminase (CSF-ADA) activity which was measured at the Chemical Pathology Laboratory of Princess Margaret Hospital, the sole centre providing such service in Hong Kong, for 51 patients with suspected meningitis from nine local hospitals between June 2014 and July 2017. TBM diagnosis was defined by positive culture and/or nucleic acid amplification test result of Mycobacterium tuberculosis complex in CSF.ResultsCSF-ADA activity was significantly higher in the TBM group (8.6±2.1 IU/L, n=8) than that of the non-TBM group (2.8±5.9 IU/L, n=43). The optimal clinical cut-off of 5.1 U/L for TBM diagnosis in our laboratory yielded 100% sensitivity, 91% specificity, positive likelihood ratio of 10.8 and negative likelihood ratio of 0. In rare circumstance, false elevation may be seen in non-tuberculous cause, such as central nervous system lymphoma and fungal infection.ConclusionsWe recommend the use of CSF-ADA activity, which is a simple, fast and robust test for early differentiation of TBM from other causes, to facilitate timely initiation of antituberculous treatment and potentially improve patients’ outcome.

scholarly journals CUT-OFF VALUE ADENOSINE DEAMINASE ACTIVITY IN CEREBROSPINAL FLUID FOR DIAGNOSIS OF TUBERCULOUS MENINGITIS

2019 ◽  
Vol 8 (3) ◽  
pp. 177-179
Author(s):  
Ramaswamy T. ◽  
Bhaskar Rao ◽  
Kalyan Kumar P. V. ◽  
Ramakrishna G. ◽  
Ramakrishna R.
Keyword(s):  
Cerebrospinal Fluid ◽  
Adenosine Deaminase ◽  
Tuberculous Meningitis ◽  
Adenosine Deaminase Activity

scholarly journals Evaluation of Cerebrospinal fluid adenosine deaminase activity as a complimentary tool in the early diagnosis of tuberculous meningitis in children

2012 ◽  
Vol 8 (2) ◽  
pp. 17-23 ◽  
Author(s):  
A Pan ◽  
A Biswas ◽  
A Chaterjee ◽  
R Kumar
Keyword(s):  
Cerebrospinal Fluid ◽  
Adenosine Deaminase ◽  
Tuberculous Meningitis ◽  
Laboratory Diagnosis ◽  
Clinical Findings ◽  
Medical Sciences ◽  
Delay In Diagnosis ◽  
Csf Analysis ◽  
Adenosine Deaminase Activity ◽  
Meningitis In Children

The diagnosis of tuberculous meningitis cannot be made or excluded on the basis of clinical findings. Definite laboratory diagnosis is cumbersome and time consuming. Delay in diagnosis and institution of proper treatment is directly related to poor outcome and sequalae. Adenosine deaminase activity (ADA) was estimated in cerebrospinal fluid (CSF) in addition to routine CSF analysis of 32 patients of tuberculous meningitis (TBM) and 7 patients of partially treated pyomeningitis (PTM), 10 patients aseptic meningitis (AM) and 13 patients pyogenic meningitis (PM). Mean ADA levels in CSF of TBM patients were higher (15.42 U/L) as compared to 7.21 U/L, 6.41 U/L and 7.50 U/L in PTM, AM and PM respectively. This difference of ADA values in CSF between TBM and other types of meningitis was statistically significant (p<0.01). ADA values were also compared with other biochemical and cytological parameters of CSF & a positive correlation was found with CSF protein level. Sensitivity and specificity of ADA levels in CSF of children to diagnose tuberculous meningitis was 75% and 90% respectively at 10 U/L cut off of ADA levels in CSF. Journal of College of Medical Sciences-Nepal,2012,Vol-8,No-2, 17-23 DOI: http://dx.doi.org/10.3126/jcmsn.v8i2.6833

Rational application of adenosine deaminase activity in cerebrospinal fluid for the diagnosis of tuberculous meningitis

Infection ◽  
2015 ◽  
Vol 43 (5) ◽  
pp. 531-535 ◽  
Author(s):  
Jorge Parra-Ruiz ◽  
V. Ramos ◽  
C. Dueñas ◽  
N. M. Coronado-Álvarez ◽  
R. Cabo-Magadán ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Adenosine Deaminase ◽  
Tuberculous Meningitis ◽  
Rational Application ◽  
Adenosine Deaminase Activity
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