Comparison of the bioavailability and tolerability of fixed-dose combination glimepiride/metformin 2/500-mg tablets versus separate tablets: A single-dose, randomized-sequence, open-label, two-period crossover study in healthy Korean volunteers

Namyi Gu; Bo-Hyung Kim; HyouYoung Rhim; Jae-Yong Chung; Jung-Ryul Kim; Hyun-Suk Shin; Seo-Hyun Yoon; Joo-Youn Cho; Sang-Goo Shin; In-Jin Jang; Kyung-Sang Yu

doi:10.1016/j.clinthera.2010.07.012

Comparison of the bioavailability and tolerability of fixed-dose combination glimepiride/metformin 2/500-mg tablets versus separate tablets: A single-dose, randomized-sequence, open-label, two-period crossover study in healthy Korean volunteers

Clinical Therapeutics ◽

10.1016/j.clinthera.2010.07.012 ◽

2010 ◽

Vol 32 (7) ◽

pp. 1408-1418 ◽

Cited By ~ 7

Author(s):

Namyi Gu ◽

Bo-Hyung Kim ◽

HyouYoung Rhim ◽

Jae-Yong Chung ◽

Jung-Ryul Kim ◽

...

Keyword(s):

Single Dose ◽

Crossover Study ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Open Label ◽

Dose Combination ◽

Separate Tablets

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Bioequivalence of Fixed Dose Combination of Atorvastatin 10 mg and Aspirin 150 mg Capsules: A Randomized, Open-Label, Single-Dose, Two-way Crossover Study in Healthy Human Subjects

Drug Research ◽

10.1055/s-0033-1337931 ◽

2013 ◽

Vol 63 (05) ◽

pp. 250-257 ◽

Cited By ~ 1

Author(s):

S. Tippabhotla ◽

M. Betha ◽

C. Gadiko ◽

R Battula ◽

M. Nakkawar ◽

...

Keyword(s):

Single Dose ◽

Crossover Study ◽

Human Subjects ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Open Label ◽

Healthy Human ◽

Healthy Human Subjects ◽

Dose Combination

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Pharmacokinetic Comparison of 2 Fixed-Dose Combination Tablets of Amlodipine and Valsartan in Healthy Male Korean Volunteers: A Randomized, Open-Label, 2-Period, Single-Dose, Crossover Study

Clinical Therapeutics ◽

10.1016/j.clinthera.2013.05.021 ◽

2013 ◽

Vol 35 (7) ◽

pp. 934-940 ◽

Cited By ~ 7

Author(s):

Yukyung Kim ◽

Mijeong Son ◽

Donghwan Lee ◽

Hyerang Roh ◽

Hankil Son ◽

...

Keyword(s):

Single Dose ◽

Crossover Study ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Healthy Male ◽

Open Label ◽

Dose Combination

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The Pharmacokinetics and Safety of a Fixed-Dose Combination of Acetylsalicylic Acid and Clopidogrel Compared With the Concurrent Administration of Acetylsalicylic Acid and Clopidogrel in Healthy Subjects: A Randomized, Open-Label, 2-Sequence, 2-Period, Single-Dose Crossover Study

Clinical Therapeutics ◽

10.1016/j.clinthera.2013.05.015 ◽

2013 ◽

Vol 35 (7) ◽

pp. 985-994 ◽

Cited By ~ 8

Author(s):

Jin Ah Jung ◽

Tae-Eun Kim ◽

Jung-Ryul Kim ◽

Min-Ji Kim ◽

Wooseong Huh ◽

...

Keyword(s):

Single Dose ◽

Acetylsalicylic Acid ◽

Crossover Study ◽

Healthy Subjects ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Concurrent Administration ◽

Open Label ◽

Dose Combination

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Bioequivalence of Fexofenadine and Montelukast Fixed Dose Combination Tablet with Individual Components: Single-dose, Randomized, Open-label, Two-period, Crossover Study in India

Indian Journal of Pharmaceutical Sciences ◽

10.4172/pharmaceutical-sciences.1000164 ◽

2016 ◽

Vol 78 (5) ◽

Author(s):

A Walekar ◽

Deepa Chodankar ◽

M Naqvi ◽

C Trivedi

Keyword(s):

Single Dose ◽

Crossover Study ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Open Label ◽

Combination Tablet ◽

Dose Combination

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Pharmacokinetics of Rosuvastatin/Olmesartan Fixed-Dose Combination: A Single-Dose, Randomized, Open-Label, 2-Period Crossover Study in Healthy Korean Subjects

Clinical Therapeutics ◽

10.1016/j.clinthera.2013.05.016 ◽

2013 ◽

Vol 35 (7) ◽

pp. 915-922 ◽

Cited By ~ 7

Author(s):

Hankil Son ◽

Hyerang Roh ◽

Donghwan Lee ◽

HeeChul Chang ◽

JunKu Kim ◽

...

Keyword(s):

Single Dose ◽

Crossover Study ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Open Label ◽

Dose Combination

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Pharmacokinetic and Pharmacodynamic Comparison of Two Formulations of a Fixed-Dose Combination of Gemigliptin/Rosuvastatin 50/20 mg: A Randomized, Open-Label, Single-Dose, Two-Way Crossover Study

Drug Design Development and Therapy ◽

10.2147/dddt.s288986 ◽

2021 ◽

Vol Volume 15 ◽

pp. 651-658

Author(s):

Eunsol Yang ◽

Hyounggyoon Yoo ◽

In-Jin Jang ◽

Kyung-Sang Yu ◽

SeungHwan Lee

Keyword(s):

Single Dose ◽

Crossover Study ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Open Label ◽

Dose Combination

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Relative bioavailability of a 5 mg mosapride/10 mg rabeprazole fixed dose combination tablet versus separate single tablets in healthy volunteers: a single-dose randomized open-label crossover study

Current Medical Research and Opinion ◽

10.1185/03007995.2011.624088 ◽

2011 ◽

Vol 27 (11) ◽

pp. 2203-2211 ◽

Cited By ~ 1

Author(s):

G.A. Keller ◽

P. Czerniuk ◽

R. Bertuola ◽

F. de Mena ◽

M.V. Simoni ◽

...

Keyword(s):

Single Dose ◽

Crossover Study ◽

Healthy Volunteers ◽

Relative Bioavailability ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Open Label ◽

Combination Tablet ◽

Dose Combination

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Pharmacokinetics of a telmisartan/rosuvastatin fixed-dose combination: a single-dose, randomized, open-label, 2-period crossover study in healthy Korean subjects

International Journal of Clinical Pharmacology and Therapeutics ◽

10.5414/cp202412 ◽

2015 ◽

Vol 53 (10) ◽

pp. 883-889 ◽

Cited By ~ 3

Author(s):

Dong Woo Chae ◽

Mijeong Son ◽

Yukyung Kim ◽

Hankil Son ◽

Seong Bok Jang ◽

...

Keyword(s):

Single Dose ◽

Crossover Study ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Open Label ◽

Dose Combination

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Comparison of the Pharmacokinetics of Highly Variable Drugs in Healthy Subjects Using a Partial Replicated Crossover Study: A Fixed-Dose Combination of Fimasartan 120 mg and Atorvastatin 40 mg versus Separate Tablets

Drug Design Development and Therapy ◽

10.2147/dddt.s233732 ◽

2020 ◽

Vol Volume 14 ◽

pp. 1953-1961 ◽

Cited By ~ 1

Author(s):

Jungi Hwang ◽

Kyung-Sang Yu ◽

SeungHwan Lee

Keyword(s):

Crossover Study ◽

Healthy Subjects ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Highly Variable Drugs ◽

Dose Combination ◽

Separate Tablets

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Implementation of a Reference-Scaled Average Bioequivalence Approach for Highly Variable Acetylsalicylic Acid in Fixed-Dose Combination with Clopidogrel Versus Enteric Aspirin in Chinese Subjects Under Fasting Conditions: A Phase 1, Open-Label, Randomized, Crossover Study

Advances in Therapy ◽

10.1007/s12325-020-01369-z ◽

2020 ◽

Vol 37 (6) ◽

pp. 2696-2709

Author(s):

Lu Wang ◽

Yujing Di ◽

Tingting Guo ◽

Jeffrey E. Ming ◽

Fangyuan Kong ◽

...

Keyword(s):

Acetylsalicylic Acid ◽

Crossover Study ◽

Phase 1 ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Open Label ◽

Average Bioequivalence ◽

Dose Combination ◽

Randomized Crossover Study ◽

Chinese Subjects

Download Full-text