scholarly journals Proteoform Analysis to Fulfill Unmet Clinical Needs and Reach Global Standardization of Protein Measurands in Clinical Chemistry Proteomics

2018 ◽  
Vol 38 (3) ◽  
pp. 487-497 ◽  
Author(s):  
Yuri E.M. van der Burgt ◽  
Christa M. Cobbaert
Keyword(s):  
Clinical Chemistry ◽  
Global Standardization

scholarly journals Global FT4 immunoassay standardization: an expert opinion review

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Juergen Kratzsch ◽  
Nikola A. Baumann ◽  
Ferruccio Ceriotti ◽  
Zhong X. Lu ◽  
Matthias Schott ◽  
...  
Keyword(s):  
Clinical Chemistry ◽  
Method Comparison ◽  
Clinical Decision ◽  
Reference Intervals ◽  
Clinical Impact ◽  
Specific Reference ◽  
Thyroid Function Tests ◽  
Global Standardization ◽  
Collaborative Efforts ◽  
Clinical Decision Limits

Abstract Objectives Results can vary between different free thyroxine (FT4) assays; global standardization would improve comparability of results between laboratories, allowing development of common clinical decision limits in evidence-based guidelines. Content We summarize the path to standardization of FT4 assays, and challenges associated with FT4 testing in special populations, including the need for collaborative efforts toward establishing population-specific reference intervals. The International Federation of Clinical Chemistry and Laboratory Medicine Committee for Standardization of Thyroid Function Tests has undertaken FT4 immunoassay method comparison and recalibration studies and developed a reference measurement procedure that is currently being validated. Further studies are needed to establish common reference intervals/clinical decision limits. Standardization of FT4 assays will change test results substantially; therefore, a major education program will be required to ensure stakeholders are aware of the benefits of FT4 standardization, planned transition procedure, and potential clinical impact of the changes. Assay recalibration by manufacturers and approval process simplification by regulatory authorities will help minimize the clinical impact of standardization. Summary Significant progress has been made toward standardization of FT4 testing, but technical and logistical challenges remain. Outlook Collaborative efforts by manufacturers, laboratories, and clinicians are required to achieve successful global standardization of the FT4 assays.

Drug-interference in clinical chemistry analyses pseudohypertriglyceridaemia

2014 ◽  
Vol 3 (2) ◽  
pp. 153
Author(s):  
P Swathi ◽  
M Prasanth ◽  
MM Suchitra ◽  
AparnaR Bitla
Keyword(s):  
Clinical Chemistry ◽  
Drug Interference

The cause of the abnormal reaction of clinical chemistry was confirmed by electrophoresis

2016 ◽  
Vol 60 (1) ◽  
pp. 27-30
Author(s):  
Masanori Seimiya ◽  
Yachiyo Endo ◽  
Mariko Watanabe ◽  
Haruna Asano ◽  
Saori Honda ◽  
...  
Keyword(s):  
Clinical Chemistry

Textbook of clinical chemistry

1986 ◽  
Vol 14 (3) ◽  
pp. 146 ◽  
Author(s):  
F Vella
Keyword(s):  
Clinical Chemistry

scholarly journals Generation and Characterization of dickkopf3 Mutant Mice

2006 ◽  
Vol 26 (6) ◽  
pp. 2317-2326 ◽  
Author(s):  
Ivan del Barco Barrantes ◽  
Ana Montero-Pedrazuela ◽  
Ana Guadaño-Ferraz ◽  
Maria-Jesus Obregon ◽  
Raquel Martinez de Mena ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Clinical Chemistry ◽  
Lung Ventilation ◽  
Immunoglobulin M ◽  
Mutant Mice ◽  
Phenotypic Analysis ◽  
Thyroid Hormone Metabolism ◽  
Hormone Binding Protein ◽  
Deficient Mice

ABSTRACT dickkopf (dkk) genes encode a small family of secreted Wnt antagonists, except for dkk3, which is divergent and whose function is poorly understood. Here, we describe the generation and characterization of dkk3 mutant mice. dkk3-deficient mice are viable and fertile. Phenotypic analysis shows no major alterations in organ morphology, physiology, and most clinical chemistry parameters. Since Dkk3 was proposed to function as thyroid hormone binding protein, we have analyzed deiodinase activities, as well as thyroid hormone levels. Mutant mice are euthyroid, and the data do not support a relationship of dkk3 with thyroid hormone metabolism. Altered phenotypes in dkk3 mutant mice were observed in the frequency of NK cells, immunoglobulin M, hemoglobin, and hematocrit levels, as well as lung ventilation. Furthermore, dkk3-deficient mice display hyperactivity.

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